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- Ji, Xuemei, et al.
(author)
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Protein-altering germline mutations implicate novel genes related to lung cancer development
- 2020
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio=8.82, P=1.18x10(-15)) and replication (adjusted OR=2.93, P=2.22x10(-3)) that is more pronounced in females (adjusted OR=6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR=2.61, P=7.98x10(-22)) and replication datasets (adjusted OR=1.55, P=0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.
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- Gudmundsson, Jón E., et al.
(author)
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The Simons Observatory : modeling optical systematics in the Large Aperture Telescope
- 2021
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In: Applied Optics. - 1559-128X .- 2155-3165. ; 60:4, s. 823-837
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Journal article (peer-reviewed)abstract
- We present geometrical and physical optics simulation results for the Simons Observatory Large Aperture Telescope. This work was developed as part of the general design process for the telescope, allowing us to evaluate the impact of various design choices on performance metrics and potential systematic effects. The primary goal of the simulations was to evaluate the final design of the reflectors and the cold optics that are now being built. We describe nonsequential ray tracing used to inform the design of the cold optics, including absorbers internal to each optics tube. We discuss ray tracing simulations of the telescope structure that allow us to determine geometries that minimize detector loading and mitigate spurious near-field effects that have not been resolved by the internal baffling. We also describe physical optics simulations, performed over a range of frequencies and field locations, that produce estimates of monochromatic far-field beam patterns, which in turn are used to gauge general optical performance. Finally, we describe simulations that shed light on beam sidelobes from panel gap diffraction.
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| 7. |
- McCarrick, Heather, et al.
(author)
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The Simons Observatory Microwave SQUID Multiplexing Detector Module Design
- 2021
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In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 922:1
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Journal article (peer-reviewed)abstract
- Advances in cosmic microwave background (CMB) science depend on increasing the number of sensitive detectors observing the sky. New instruments deploy large arrays of superconducting transition-edge sensor (TES) bolometers tiled densely into ever larger focal planes. High multiplexing factors reduce the thermal loading on the cryogenic receivers and simplify their design. We present the design of focal-plane modules with an order of magnitude higher multiplexing factor than has previously been achieved with TES bolometers. We focus on the novel cold readout component, which employs microwave SQUID multiplexing (μmux). Simons Observatory will use 49 modules containing 70,000 bolometers to make exquisitely sensitive measurements of the CMB. We validate the focal-plane module design, presenting measurements of the readout component with and without a prototype detector array of 1728 polarization-sensitive bolometers coupled to feedhorns. The readout component achieves a 95% yield and a 910 multiplexing factor. The median white noise of each readout channel is 65 pA √Hz . This impacts the projected SO mapping speed by <8%, which is less than is assumed in the sensitivity projections. The results validate the full functionality of the module. We discuss the measured performance in the context of SO science requirements, which are exceeded.
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- Chesmore, Grace E., et al.
(author)
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Simons Observatory : characterizing the Large Aperture Telescope Receiver with radio holography
- 2022
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In: Applied Optics. - 1559-128X .- 2155-3165. ; 61:34, s. 10309-10319
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Journal article (peer-reviewed)abstract
- We present near-field radio holography measurements of the Simons Observatory Large Aperture Telescope Receiver optics. These measurements demonstrate that radio holography of complex millimeter-wave optical systems comprising cryogenic lenses, filters, and feed horns can provide detailed characterization of wave propagation before deployment. We used the measured amplitude and phase, at 4 K, of the receiver near-field beam pattern to predict two key performance parameters: 1) the amount of scattered light that will spill past the telescope to 300 K and 2) the beam pattern expected from the receiver when fielded on the telescope. These cryogenic measurements informed the removal of a filter, which led to improved optical efficiency and reduced sidelobes at the exit of the receiver. Holography measurements of this system suggest that the spilled power past the telescope mirrors will be less than 1%, and the main beam with its near sidelobes are consistent with the nominal telescope design. This is the first time such parameters have been confirmed in the lab prior to deployment of a new receiver. This approach is broadly applicable to millimeter and submillimeter instruments.
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- Huang, Yunbo, et al.
(author)
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Coupling of Local Wood Properties Extracted from X-ray Computed Tomography with Cutting Force
- 2023
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In: Proceedings of the 25th International Wood Machining Seminar. - : IWMS -25 Organizing Committee.
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Conference paper (peer-reviewed)abstract
- While X-ray computed tomography (CT) is used extensively in sawmills, its primary applications are improving value-yield and process automation. Three-dimensional CT scanners have also been extensively used for log sorting and sawing optimisation. However, there is hardly any resent research utilising CT from a cutting process perspective. This study addresses this gap by adopting CT to investigate the correlation between local wood properties — namely density, knots and annual rings — and cutting forces. Cutting forces for clear-wood and knotty-wood specimens of Scots pine (Pinus sylvestris L.) followed the expected trend corresponding to the density profile: dense regions led to high cutting force while other regions caused low cutting forces. However, it was found that in addition to density, knot orientation relative to cutting direction, annual ring width along the cutting path, and annual ring angle in relation to the cutting direction were critical factors that influence the cutting process. This study illustrates the feasibility of coupling local wood properties obtained from CT data with cutting force, potentially inspiring further research on a variety of wood property/cutting force relationships.
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- Orlowski, K. A., et al.
(author)
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Cutting Forces for Clear and Knotty Pine Wood
- 2023
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In: Proceedings of the 25th International Wood Machining Seminar.
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Conference paper (peer-reviewed)abstract
- Sawmill managers are interested in carrying out the sawmilling process in an efficient manner with minimal waste of raw material. In primary processing, an increase in productivity can be achieved if the process can be controlled. This can be achieved by developing a macro-mechanic model of the cutting power determination considered from a point of view of modern fracture mechanics has been developed. For the model knowledge about fracture toughness and shear yield stresses is vital. Pine wood (Pinus sylvestris L.) is a popular species which is widely used in wood industry in Poland and Sweden. Test samples with a cross section of 70 × 70 mm were originated from the both countries. Before sawing, all wood samples were scanned on X-ray Computed Tomography in laboratory conditions in Skellefteå (Sweden). These CT scans were helpful in indicating where clear and knotty samples were obtained from beams. Cutting tests were carried out on the custom-made laboratory stand in Skellefteå. The rotating arm held the wood sample, and the cutting speed equaled 15.5 ms−1. A stellite tipped tooth was fed into the wood sample with uncut chip thicknesses for clear wood 0.5; 0.7 and 1.1 mm, and for knotty wood 0.3; 0.5 and 0.7 mm. The tooth data: overall set equal to 2.9 mm, rake angle 27°, and clearance angle 12°. A piezoelectric sensor on the tooth holder measured the cutting forces. On the basis of the experimental findings it is possible to create mathematical models cutting forces for clear and knotty pine wood. For knotty wood the intercept is almost twice than for clear wood.
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