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1.	Hanson, Mikael G. V., et al. (author) A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients 2007 In: Cancer Immunology and Immunotherapy. - : Springer Science and Business Media LLC. - 0340-7004 .- 1432-0851. ; 56:7, s. 973-984 Journal article (peer-reviewed)abstract Cancer patients with advanced disease display signs of immune suppression, which constitute a major obstacle for effective immunotherapy. Both T cells and NK cells are affected by a multitude of mechanisms of which the generation of reactive oxygen species is of major importance. Therefore, we hypothesized that two weeks of high-dose treatment with the anti-oxidant vitamin E may enhance NK cell function in cancer patients by protecting from oxidative stress. Seven patients with colorectal cancer (Dukes stage C and D) received a daily dose of 750 mg of vitamin E during a period of two weeks and the function, phenotype and receptor expression of NK cells were analyzed. The short-term vitamin E treatment significantly improved NK cell cytolytic activity in six out of the seven patients analyzed. The increased NK cell activity in patients' PBMC was not due to increased numbers of NK cells or an increase in the proportion of the CD56(dim) NK cell subpopulation. Furthermore, neither an increased perforin expression nor an enhanced ability of NK cells to produce IFN-gamma was observed as a result of vitamin E treatment. Finally, vitamin E treatment was associated with a minor, but consistent, induction of NKG2D expression in all patients analyzed. In conclusion, this pilot study demonstrates that vitamin E may boost NK cell function in patients with colorectal cancer. Further studies are warranted to explore the potential of vitamin E as an adjuvant for immunotherapy against cancer and to determine the underlying mechanism(s) behind vitamin E induced NK cell activation.
2.	Ericson, EL, et al. (author) Clinical comparison of the two blood culture systems for the detection of candidemia 2009 In: MYCOSES. - 0933-7407. ; 52, s. 43-43 Conference paper (other academic/artistic)
3.	Miller, AM, et al. (author) Immune monitoring in a phase 1 trial of a PSA DNA vaccine in patients with hormone-refractory prostate cancer 2005 In: Journal of immunotherapy (Hagerstown, Md. : 1997). - : Ovid Technologies (Wolters Kluwer Health). - 1524-9557. ; 28:4, s. 389-395 Journal article (peer-reviewed)
4.	Ozenci, V, et al. (author) Presence and specificity of tumor associated lymphocytes from ascites fluid in prostate cancer 2005 In: The Prostate. - : Wiley. - 0270-4137 .- 1097-0045. ; 65:1, s. 20-26 Journal article (peer-reviewed)
5.	Ozenci, V, et al. (author) Rapid culture and identification: a practical method for early preliminary laboratory diagnosis of sepsis 2008 In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - : Elsevier BV. - 1198-743X. ; 14:2, s. 177-180 Journal article (peer-reviewed)
6.	Ozenci, V, et al. (author) RELAPSING ENDOCARDITIS DUE TO GRANULICATELLA ADIACENS 2009 In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - 0924-8579. ; 33, s. S47-S47 Conference paper (other academic/artistic)

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Result 1-6 of 6

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Type of publication: journal article (4); conference paper (2)

Type of content: peer-reviewed (4); other academic/artistic (2)

Author/Editor: Ozenci, V (5); Pisa, P (2); Miller, AM (2); Wretlind, B (1); Egevad, L (1); Kalkner, KM (1); show more...; Palmborg, A (1); Kiessling, R (1); Klingspor, L (1); Westling, K (1); Ullberg, M (1); Fang, H (1); Lundberg, C (1); Masucci, Giuseppe (1); Malmberg, Karl Johan (1); Tegmark Wisell, K (1); Ozenci, Volkan (1); Ericson, EL (1); Hanson, Mikael G. V. (1); Carlsten, Mattias C. ... (1); Glimelius, Bengt L. (1); Frödin, Jan-Erik A. (1); Kiessling, Rolf V. R ... (1); Jaremko, GA (1); Salaj, D (1); show less...

University: Karolinska Institutet (6); Uppsala University (1)

Language: English (6)

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