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Träfflista för sökning "WFRF:(Palmer D. H.) srt2:(2000-2004)"

Sökning: WFRF:(Palmer D. H.) > (2000-2004)

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  • Hegelund, F, et al. (författare)
  • High-Resolution Infrared and Microwave Study of the n20 and n21 Levels near 300 cm-1 in 1,2,4-Triazine.
  • 2003
  • Ingår i: Journal of Molecular Spectroscopy. - 0022-2852. ; 217:1, s. 9-18
  • Tidskriftsartikel (refereegranskat)abstract
    • The gas phase far-IR spectrum of the small nu, Greek20 (A″, 367.88 cm−1) and small nu, Greek21 (A″, 311.28 cm−1) bands of 1,2,4-triazine, a five membered ring having the point group Cs, has been studied at a resolution ranging from 0.002 to 0.003 cm−1. From the MW spectrum 58 transitions in the small nu, Greek20 level and 64 in the small nu, Greek21 level have been assigned. The small nu, Greek20 and small nu, Greek21 modes which are due to non-planar motions of the ring system are found to be nearly unperturbed. From a simultaneous analysis of IR and MW transitions band centers, rotational constants, and the quartic centrifugal distortion constants ΔJ, ΔJK, ΔK, small delta, GreekJ, and small delta, GreekK have been obtained using the Watson Hamiltonian, A-reduction, IIIr-representation.
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  • Åberg, Maria A I, 1972, et al. (författare)
  • IGF-I has a direct proliferative effect in adult hippocampal progenitor cells.
  • 2003
  • Ingår i: Molecular and cellular neurosciences. - 1044-7431. ; 24:1, s. 23-40
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of the present study was to investigate the potential direct effects of insulin-like growth factor-I (IGF-I) on adult rat hippocampal stem/progenitor cells (AHPs). IGF-I-treated cultures showed a dose-dependent increase in thymidine incorporation, total number of cells, and number of cells entering the mitosis phase. Pretreatment with fibroblast growth factor-2 (FGF-2) increased the IGF-I receptor (IGF-IR) expression, and both FGF-2 and IGF-I were required for maximal proliferation. Time-lapse recordings showed that IGF-I at 100 ng/ml decreased differentiation and increased proliferation of single AHPs. Specific inhibition of mitogen-activated protein kinase kinase (MAPKK), phosphatidylinositol 3-kinase (PI3-K), or the downstream effector of the PI3-K pathway, serine/threonine p70 S6 kinase (p70(S6K)), showed that both the MAPK and the PI3-K pathways participate in IGF-I-induced proliferation but that the MAPK activation is obligatory. These results were confirmed with dominant-negative constructs for these pathways. Stimulation of differentiation was found at a low dose (1 ng/ml) of IGF-I, clonal analysis indicating an instructive component of IGF-I signaling.
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  • Resultat 1-4 av 4

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