| 1. |
- Aad, G., et al.
(author)
-
- 2014
-
In: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :6
-
Journal article (peer-reviewed)
|
|
| 2. |
- Kendler, Kenneth S., et al.
(author)
-
Does neighborhood alcohol availability moderate the impact of familial liability and marital status on risk for alcohol use disorders? A Swedish national study
- 2020
-
In: Journal of Studies on Alcohol and Drugs. - : Alcohol Research Documentation, Inc.. - 1937-1888 .- 1938-4114. ; 81:6, s. 816-823
-
Journal article (peer-reviewed)abstract
- Objective: The purpose of this study was to determine whether ease of access to alcohol at the neighborhood level moderates the impact of familial liability and marital status on risk for alcohol use disorder (AUD). Method: Individuals in Sweden were divided into those residing in a neighborhood with (n = 14.1%) versus without (n = 85.9%) an alcohol outlet (bars/nightclubs or government stores). AUD was detected through national medical, legal, and pharmacy registries. Using an additive model predicting AUD registration over 5 years in 1,624,814 individuals, we tested for interactions between the presence of outlets in the individuals’ neighborhoods and familial risk for external-izing syndromes and marital status. Results: In both males and females, we found positive and significant interactions in the prediction of AUD between the presence versus absence of a nearby alcohol outlet with (a) familial risk and (b) single and divorced versus married status. Similar but nonsignificant interactions were seen between nearby outlets and widowed versus married status. These results changed little when all cases with prior AUD were removed from the sample. For males, most of the interaction arose from the proximity of bars/nightclubs, whereas for females the results varied across different kinds of outlets. Conclusions: Environments that provide easy access to alcohol augment the impact of a range of risk factors for AUD, especially familial vulnerability and the reduced social constraints associated with single, divorced, and widowed marital status.
|
|
| 3. |
|
|
| 4. |
- Reitan, Nina K., et al.
(author)
-
Plast i byggevar och brannsikkerhet : Hovedprosjekt
- 2014
-
Reports (other academic/artistic)abstract
- Målet med prosjektet var å skape et grunnlag for at utvalgte byggvaerer i plast skal kunne brukes på en brannsikker måte. For å oppnå dette vurderer vi det som hensiktsmessigt å øke kunnskapsnivået om brannsikker håndtering av byggevarer i plast blant ulike aktører (brannvesen, prosjeterende, arkiteter og utførende). For å innhente ny kunnskap om riktig håndtering av byggevarer i plast, ble det gjort tester i fullskala og mindre skala av sandwichpaneler og plastplater. Dette er produkttyper som påstås utgjøre en brannrisiko, og som er utbredt i industri, nærings- og lagerbygg.
|
|
| 5. |
- Aad, G., et al.
(author)
-
- 2011
-
swepub:Mat__t (peer-reviewed)
|
|
| 6. |
- Aad, G., et al.
(author)
-
- 2014
-
In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
-
Journal article (peer-reviewed)
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
-
Iklädd identitet : historiska studier av kropp och kläder
- 2005
-
Editorial collection (other academic/artistic)abstract
- Vilken betydelse har kläderna på den offentliga scenen? Vad betyder gesterna: handen på höften; sättet att hålla tygeln; de sammanbitna käkarna? Denna bok är en historisk färd i mundering och kroppsspråk från 1500-talet till våra dagar. Om bakomliggande signarer, iskalla beräkningar, orimliga aspirationer, lydnad och revolt.Boken tar upp den anspråkslösa dräkten som förenar präster, sjuksköterskor, kända krigarkungar och uniformsbesatta SA-trupper. Boken tar också upp grupper som har tagit chansen att låta sitt yttre bli till ett konstverk. Det gäller 1500-talets legosoldater, filmskådespelare av båda könen och några av våra mest kända målare, här i helfigur.
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
|
|
| 15. |
- Moroni, Lorenzo, et al.
(author)
-
Micropatterned hot-embossed polymeric surfaces influence cell proliferation and alignment
- 2009
-
In: Journal of Biomedical Materials Research - Part A. - : Wiley. - 1552-4965 .- 1549-3296. ; 88A:3, s. 644-653
-
Journal article (peer-reviewed)abstract
- Micropatterning is a powerful technique to custom-make and precisely control the surface topography of materials, which is determinant for a better interaction with cells. A modification of conventional micropatterning is proposed here to fabricate textured film from stiff and sticky polymers such as poly(lactide(s)-co-glycolide(s)) (PLGA) without the use of supports or solvents. Micropatterned PLGA films with square pits varying in height and channels varying in width were made to study the influence of these topographical parameters on human fibroblasts proliferation, morphology, and alignment. With increasing the square pit height, the cell attachment efficiency increased. After 10 days of culture the micropatterned films supported a significantly higher cell proliferation than smooth films. In particular, cell growth was highly stimulated in 150-mu m-wide channels. Fibroblasts were spread with a typical spindle shape in all the films. Cell spreading increased with increasing the textured dimensions. A random cell organization was found for smooth and for square pit samples, and a high alignment was observed along the 150-mu m-wide channels. Smaller and bigger channels did not support substantial cell growth, suggesting a possible "recognition" mechanism of the cells for optimal organization. These findings could be useful in tissue engineering applications where higher proliferation rates and eventual random or unidimensional alignments of cells are desirable. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 644-653, 2009
|
|
| 16. |
- Paulrud, Susanne, et al.
(author)
-
Methane emissions from residential biomass combustion
- 2005
-
Reports (other academic/artistic)abstract
- Small scale biomass combustion can be a major source of air pollutants like hydrocarbons and particulate matters. Methane is one of the hydrocarbons emitted when burning biomass fuels and recent studies show that methane emissions from different kinds of residential biomass systems can vary significantly depending on type of combustion system and type of fuel. On a yearly basis Sweden is obligated to report air emissions of several pollutants to different international bodies. In previous reporting only one emission factor for methane is accounted for, including all technologies and all fuel types. This study aims to improve the reporting of methane emissions from small scale combustion of biomass by revising both activity data and emission factors. Further, the times series 1990-2003 for methane emission will be updated. New methane emission factors from small scale combustion of wood log, pellets and wood chips/sawdust was determined and an improved method was then used to calculate the emissions. In order to match the activity data categories, the emission factors were grouped by heating system category and fuel type. The result showed that methane emissions from wood log combustion are significantly higher compared to pellets combustion. However, significant variations in emission factors occur for specific combustion appliances and operation conditions. The recalculated time series for 1990-2003 showed higher values of methane emissions due to desegregation of emission factors by combustion technology.
|
|
| 17. |
- Pecorari, Diane, 1964-, et al.
(author)
-
So what should we do?
- 2019
-
In: Student Plagiarism in Higher Education. - : Routledge. - 9781138055155 - 9781315166148 ; , s. 157-168
-
Book chapter (other academic/artistic)
|
|
| 18. |
- Rodriguez, Juan, et al.
(author)
-
Mechanical weathering effect on tailing particles
- 2016
-
In: Proceedings of Nordic Conference on Soil Mechanics and Geotechnical NGM.
-
Conference paper (peer-reviewed)abstract
- Over the last century the tailing volume generation has grown dramatically due to the mineral demand. Nowadays the mining industry is producing every year millions of tons of tailings. The storage of the tailings has become a challenge due to the increased storage capacity demanded. Physical risk associated to the tailings dams is the stability itself since tailing dams are considered a walk-away solution. Physical changes as breakage and shape occur to the tailing particles affecting the stability of the fills by reduced strength properties. In order to understand the reduction and shape changes of tailing particles degradation test by milling attrition (erosion) and image analysis was conducted. Uniform fractions 1-0.5, 0.5-025, 0.25-0.125 and 0.125-0.063mm were used.Results have shown that attrition agents e.g. ball attrition can increase the physical erosion but also change the shape of the particles compared with autogenous attrition. However particles shape has become more regular (less elongated) and rounded in coarse fractions 1-0.5 and 0.5-0.25mm while smaller fractions 0.25-0.125 and 0.125-0.063mm seems to have opposite behavior. Comparison with previous milling studies show consistent differences probably due to the breakage of the particles was the objective. In perspective if tailings become more rounded the strength could be compromised. More studies are needed to verify this.
|
|
| 19. |
- Aad, G., et al.
(author)
-
- 2013
-
In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :3
-
Journal article (peer-reviewed)
|
|
| 20. |
- Adamina, Michel, et al.
(author)
-
ECCO Topical Review Optimising Reporting in Surgery, Endoscopy, and Histopathology Collaboration Between S-ECCO, EduCom, H-ECCO
- 2021
-
In: Journal of Crohn's & Colitis. - : OXFORD UNIV PRESS. - 1873-9946 .- 1876-4479. ; 15:7, s. 1089-1105
-
Research review (peer-reviewed)abstract
- Background and Aims: Diagnosis and management of inflammatory bowel diseases [IBD] requires a lifelong multidisciplinary approach.The quality of medical reporting is crucial in this context.The present topical review addresses the need for optimised reporting in endoscopy, surgery, and histopathology. Methods: A consensus expert panel consisting of gastroenterologists, surgeons, and pathologists, convened by the European Crohns and Colitis Organisation, performed a systematic literature review. The following topics were covered: in endoscopy: [i] general IBD endoscopy; [ii] disease activity and surveillance; [iii] endoscopy treatment in IBD; in surgery: [iv] medical history with surgical relevance, surgical indication, and strategy; [v] operative approach; [vi] intraoperative disease description; [vii] operative steps; in pathology: [viii] macroscopic assessment and interpretation of resection specimens; [ix] IBD histology, including biopsies, surgical resections, and neoplasia; [x] IBD histology conclusion and report. Statements were developed using a Delphi methodology incorporating two consecutive rounds. Current practice positions were set when >= 80% of participants agreed on a recommendation. Results: Thirty practice positions established a standard terminology for optimal reporting in endoscopy, surgery, and histopathology. Assessment of disease activity, surveillance recommendations, advice to surgeons for operative indication and strategies, including margins and extent of resection, and diagnostic criteria of IBD, as well as guidance for the interpretation of dysplasia and cancer, were handled. A standardised report including a core set of items to include in each specialty report, was defined. Conclusions: Interdisciplinary high-quality care requires thorough and standardised reporting across specialties.This topical review offers an actionable framework and practice recommendations to optimise reporting in endoscopy, surgery, and histopathology.
|
|
| 21. |
- Beth, Arnaud, et al.
(author)
-
First investigation of the diamagnetic cavity boundary layer with a 1D3V PIC simulation
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 667
-
Journal article (peer-reviewed)abstract
- Context: Amongst the different features and boundaries encountered around comets, one remains of particular interest to the plasma community: the diamagnetic cavity. Crossed for the first time at 1P/Halley during the Giotto flyby in 1986 and later met more than 700 times by the ESA Rosetta spacecraft around Comet 67P/Churyumov-Gerasimenko, this region, almost free of any magnetic field, surrounds nuclei of active comets. However, previous observations and modelling of this part of the coma have not yet provided a definitive answer as to the origin of such a cavity and on its border, the diamagnetic cavity boundary layer.Aims: We investigate which forces and equilibrium might be at play and balance the magnetic pressure at this boundary down to the spatial and temporal scales of the electrons in the 1D collisionless case. In addition, we scrutinise assumptions made in magneto-hydrodynamic and hybrid simulations of this environment and check for their validity.Methods: We simulated this region at the electron scale by means of 1D3V particle-in-cell simulations and SMILEI code.Results: Across this layer, depending on the magnetic field strength, the electric field is governed by different equilibria, with a thin double-layer forming ahead. In addition, we show that the electron distribution function departs from Maxwellian and/or gyrotropic distributions and that electrons do not behave adiabatically. We demonstrate the need to investigate this region at the electron scale in depth with fully kinetic simulations.
|
|
| 22. |
- Beth, Arnaud, et al.
(author)
-
ROSINA ion zoo at Comet 67P
- 2020
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 642
-
Journal article (peer-reviewed)abstract
- Context: The Rosetta spacecraft escorted Comet 67P/Churyumov-Gerasimenko for 2 yr along its journey through the Solar System between 3.8 and 1.24 au. Thanks to the high resolution mass spectrometer on board Rosetta, the detailed ion composition within a coma has been accurately assessed in situ for the very first time.Aims: Previous cometary missions, such as Giotto, did not have the instrumental capabilities to identify the exact nature of the plasma in a coma because the mass resolution of the spectrometers onboard was too low to separate ion species with similar masses. In contrast, the Double Focusing Mass Spectrometer (DFMS), part of the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis on board Rosetta (ROSINA), with its high mass resolution mode, outperformed all of them, revealing the diversity of cometary ions.Methods: We calibrated and analysed the set of spectra acquired by DFMS in ion mode from October 2014 to April 2016. In particular, we focused on the range from 13–39 u q−1. The high mass resolution of DFMS allows for accurate identifications of ions with quasi-similar masses, separating 13C+ from CH+, for instance.Results: We confirm the presence in situ of predicted cations at comets, such as CHm+ (m = 1−4), HnO+ (n = 1−3), O+, Na+, and several ionised and protonated molecules. Prior to Rosetta, only a fraction of them had been confirmed from Earth-based observations. In addition, we report for the first time the unambiguous presence of a molecular dication in the gas envelope of a Solar System body, namely CO2++.
|
|
| 23. |
|
|
| 24. |
- Campbell, J, et al.
(author)
-
Systematics of Halosarpheia based on morphological and molecular data.
- 2003
-
In: Mycologia. - 0027-5514 .- 1557-2536. ; 95:3
-
Journal article (peer-reviewed)abstract
- The genus Halosarpheia (Halosphaeriales) was established for marine ascomycetes with obpyriform to sub-globose, coriaceous, brown to black ostiolate ascomata with long necks; hamathecia of catenophyses; thin-walled, unitunicate, persistent asci with thick-walled apices; and ellipsoid, one septate, hyaline ascospores equipped with coiled, threadlike apical appendages that unfurl in water. Emphasis on ascospore appendage morphology has led to the inclusion in the genus of morphologically disparate fungi from a variety of marine and freshwater habitats. To better understand the evolutionary relationships of Halosarpheia species, phylogenetic analyses were conducted on 16 Halosarpheia species, 13 other species of Halosphaeriales and representatives of the Microascales, Hypocreales, Sordariales and Xylariales using 18S and 28S rDNA sequence data. All of the Halosarpheia species occurred on the Halosphaeriales clade. The type species of the genus, H. fibrosa, occurred on a well-supported clade with two morphologically similar species, H. trullifera and H. unicellularis. This clade, which phylogenetically was distant from the clades of other Halosarpheia species, represents the genus Halosarpheia sensu stricto. The other Halosarpheia species were distributed among eight other well-supported clades clearly separated from one another based on molecular data. New generic names are established for six of these clades, one new species is described, and one species is transferred to Aniptodera. A table (Table I) comparing the morphology, habitat, substrate and distribution of the genera of aquatic ascomycetes with coiled, threadlike apical appendages treated in this study is provided, along with a key for their identification.
|
|
| 25. |
-
Contemporary Muslim Travel Cultures : Practices, Complexities and Emerging Issues
- 2022
-
Editorial collection (other academic/artistic)abstract
- This timely volume brings together various issues in Muslim consumer cultures and provides a comprehensive account of Muslim tourism and tourist behaviour. Islam is a major international religion and Muslims are a majority of the population in many countries in Asia, the Middle East and North Africa. The growth of a substantial middle class, the development of Islamic consumer cultures, rising Muslim market consumption in non-Muslim majority destinations and the growing significance of intra-Muslim traffic and rising outbound tourism expenditure in emerging Muslim markets have all contributed to substantial interest in Muslim tourism. However, travel by Muslims is about far more than the Hajj and Umrah, as important as they are as acts of devotion. Instead, although often portrayed in the West as a monolithic religion, Muslim travel and leisure behaviour is very diverse, with different traditions and cultures leading to a range of expressions of tourism-related consumption culture and practices. Drawing on a range of empirical studies undertaken in different social and economic contexts and countries, this book provides a well-balanced portrayal of the Muslim tourism experience and practices. This book makes a substantial contribution to an improved understanding of Muslim travel culture and will be required reading for anyone interested in this fast-growing market.
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
- De Rezende, Rafael B., et al.
(author)
-
A shadow rate without a lower bound constraint
- 2020
-
Reports (other academic/artistic)abstract
- We propose a shadow rate that measures the overall stance of monetary policy when the lower bound is not necessarily binding. Using daily yield curve data we estimate shadow rates for the US, Sweden, the euro area and the UK, and document that they fall (rise) as monetary policy becomes more expansionary (contractionary). This ability of the shadow rate to track the stance of monetary policy is identified on announcements of policy rate cuts (hikes), balance sheet expansions (contractions) and forward guidance, with shadow rates responding in a timely fashion, and in line with government bond yields. We show two applications for our shadow rate. First, we decompose shadow rate responses to monetary policy announcements into conventional and unconventional monetary policy surprises, and assess the pass-through of each type of policy to exchange rates. We find that exchange rates respond more to conventional than to unconventional monetary policy. Lastly, a counterfactual experiment in a DSGE model suggests that inflation in Sweden would have been around half a percentage point lower had unconventional monetary policy not been used since February 2015.
|
|
| 29. |
- Fan, Qingshuang, et al.
(author)
-
Structure and scalar correlation of ammonia/air turbulent premixed flames in the distributed reaction zone regime
- 2022
-
In: Combustion and Flame. - : Elsevier BV. - 0010-2180. ; 241
-
Journal article (peer-reviewed)abstract
- Instantaneous structures of turbulent premixed ammonia/air flames on a piloted jet burner were investigated using simultaneous planar laser-induced fluorescence (PLIF) and Rayleigh thermometry measurements. Two-dimensional spatial distributions of temperature were simultaneously measured with those of the NH radical and the NO pollutant, respectively. Experiments were conducted for stoichiometric flames under five jet velocities. All flames are located in the distributed reaction zone regime of the Borghi-Peters diagram with the Karlovitz (Ka) number ranging from 274 to 4720. The NH PLIF images are used to characterize the fuel consumption layer of the reaction zones since the formation of NH is associated with the consumption of ammonia. The NH PLIF results show that under all flame conditions investigated, the NH layer remains thin in the proximity of the burner while it becomes progressively thickened and distorted by turbulence with increasing turbulent intensity and axial distance. For flames with Ka of 274, the NH layer essentially remains thin, while at Ka of 590 or higher, significant broadening of the NH layer is observed. Probability density functions (PDFs) of the NH layer thickness show that the NH layer can be broadened by 3 – 4 times as the flames are developed downstream. The broadening of the NH layer is considered to indicate that the flames are in the distributed reaction zone regime. The boundary between the thin-reaction zone regime and the distributed reaction zone regime occurs at a much larger Ka than that in methane/air flames. The broadening of the NH layer is due to the penetration of the turbulent eddies and the merging of flame branches. The latter occurs mainly near the flame tips. NO is shown to exist in a wide region in space, across the preheat zone, reaction zone, and postflame zone. NO formation occurs mainly in the reaction zone, however, it is transported by turbulence eddies to the preheat zone and by convection to the postflame zone. The temperature measurements indicate that the preheat zone is broadened in all flames investigated. The broadening of the preheat zone is moderately sensitive to the Ka number while it is more sensitive to the integral length scale of the flames.
|
|
| 30. |
- Gallego-Marcos, Ignacio, et al.
(author)
-
Effective momentum induced by steam condensation in the oscillatory bubble regime
-
Other publication (other academic/artistic)abstract
- The spargers used in Boiling Water Reactors (BWR) discharge steam from the primary coolant system into a pool of water. Direct steam condensation in subcooled water creates sources of heat and momentum determined by the condensation regimes, called “effective sources” in this work. Competition between the effective sources can result in thermally stratification or mixing of the pool. Thermal stratification is a safety concern in BWRs since it reduces the steam condensation and pressure suppression capacity of the pool. In this work, we present semi-empirical correlations to predict the effective momentum induced by steam condensation in the oscillatory bubble regime, relevant for the operation of spargers in BWRs. A Separate Effect Facility (SEF) was designed and built at LUT, Finland, in order to provide the necessary data. An empirical correlation for the effective momentum as a function of the Jakob number is proposed. The Kelvin Impulse theory was also applied to estimate the effective momentum based on information about the bubble dynamics. To do this, new correlations for the bubble collapse frequencies, maximum bubble radius, velocities, pressure gradient and heat transfer coefficient are proposed and compared to available data from the literature. The effective momentum induced by sonic steam jets appears to be constant in a wide range of studied Jakob number. However, further experimental data is necessary at larger Jakob numbers and steam mass fluxes.
|
|
| 31. |
- Grivickas, V., et al.
(author)
-
Carrier lifetimes and influence of in-grown defects in N-B Co-doped 6H-SiC
- 2014
-
In: IOP Conference Series. - : Institute of Physics Publishing (IOPP). ; 56:1, s. 012004-
-
Conference paper (peer-reviewed)abstract
- The thick N-B co-doped epilayers were grown by the fast sublimation growth method and the depth-resolved carrier lifetimes have been investigated by means of the free-carrier absorption (FCA) decay under perpendicular probe-pump measurement geometry. In some samples, we optically reveal in-grown carbon inclusions and polycrystalline defects of substantial concentration and show that these defects slow down excess carrier lifetime and prevent donor-acceptor pair photo luminescence (DAP PL). A pronounced electron lifetime reduction when injection level approaches the doping level was observed. It is caused by diffusion driven non-radiative recombination. However, the influence of surface recombination is small and insignificant at 300 K.
|
|
| 32. |
|
|
| 33. |
- Huyben, David, et al.
(author)
-
Effects of dietary yeast inclusion and acute stress on post-prandial whole blood profiles of dorsal aorta-cannulated rainbow trout
- 2017
-
In: Fish Physiology and Biochemistry. - : Springer Science and Business Media LLC. - 0920-1742 .- 1573-5168. ; 43, s. 421-434
-
Journal article (peer-reviewed)abstract
- Yeast is a potential alternative to fish meal in diets for farmed fish, yet replacing more than 50 % of fish meal results in reduced fish growth. In a 4-week experiment, 15 rainbow trout (Oncorhynchus mykiss) were cannulated and fed three diets each week: 30 % fish meal as a control (FM); 60 % replacement of fish meal protein, on a digestible basis, with Saccharomyces cerevisiae (SC); and 60 % replacement with Wickerhamomyces anomalus and S. cerevisiae mix (WA). Blood was collected at 0, 3, 6, 12 and 24 h after feeding. In the final week, fish were exposed to a 1-min netting stressor to evaluate possible diet-stress interactions. Significant increases in pH, TCO2, HCO3 and base excess were found after fish were fed the SC and WA diets compared with FM, which elevated blood alkaline tides. Yeast ingredients had lower buffering capacity and ash content than fish meal, which explained the increase in alkaline tides. In addition, fish fed the WA diet had significantly reduced erythrocyte area and fish fed SC and WA diets had increased mean corpuscular haemoglobin levels, indicating haemolytic anaemia. Higher levels of nucleic acid in yeast-based diets and potentially higher production of reactive oxygen species were suspected of damaging haemoglobin, which require replacement by smaller immature erythrocytes. Acute stress caused the expected rise in cortisol and glucose levels, but no interaction with diet was found. These results show that replacing 60 % of fish meal protein with yeasts can induce haemolytic anaemia in rainbow trout, which may limit yeast inclusion in diets for farmed fish.
|
|
| 34. |
- Karthigeyan, Dhanasekaran, et al.
(author)
-
SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool
- 2014
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 111:29, s. 10416-10421
-
Journal article (peer-reviewed)abstract
- We demonstrate the use of surface-enhanced Raman spectroscopy (SERS) as an excellent tool for identifying the binding site of small molecules on a therapeutically important protein. As an example, we show the specific binding of the common antihypertension drug felodipine to the oncogenic Aurora A kinase protein via hydrogen bonding interactions with Tyr-212 residue to specifically inhibit its activity. Based on SERS studies, molecular docking, molecular dynamics simulation, biochemical assays, and point mutation-based validation, we demonstrate the surface-binding mode of this molecule in two similar hydrophobic pockets in the Aurora A kinase. These binding pockets comprise the same unique hydrophobic patches that may aid in distinguishing human Aurora A versus human Aurora B kinase in vivo. The application of SERS to identify the specific interactions between small molecules and therapeutically important proteins by differentiating competitive and noncompetitive inhibition demonstrates its ability as a complementary technique. We also present felodipine as a specific inhibitor for oncogenic Aurora A kinase. Felodipine retards the rate of tumor progression in a xenografted nude mice model. This study reveals a potential surface pocket that may be useful for developing small molecules by selectively targeting the Aurora family kinases.
|
|
| 35. |
- Lin, Chung-Ying, et al.
(author)
-
Using Hospital Anxiety and Depression Scale (HADS) on patients with epilepsy : Confirmatory factor analysis and Rasch models
- 2017
-
In: Seizure. - : Elsevier. - 1059-1311 .- 1532-2688. ; 45, s. 42-46
-
Journal article (peer-reviewed)abstract
- PurposeThe problems of mood disorders are critical in people with epilepsy. Therefore, there is a need to validate a useful tool for the population. The Hospital Anxiety and Depression Scale (HADS) has been used on the population, and showed that it is a satisfactory screening tool. However, more evidence on its construct validity is needed.MethodA total of 1041 people with epilepsy were recruited in this study, and each completed the HADS. Confirmatory factor analysis (CFA) and Rasch analysis were used to understand the construct validity of the HADS. In addition, internal consistency was tested using Cronbachs’ α, person separation reliability, and item separation reliability. Ordering of the response descriptors and the differential item functioning (DIF) were examined using the Rasch models.ResultsThe HADS showed that 55.3% of our participants had anxiety; 56.0% had depression based on its cutoffs. CFA and Rasch analyses both showed the satisfactory construct validity of the HADS; the internal consistency was also acceptable (α = 0.82 in anxiety and 0.79 in depression; person separation reliability = 0.82 in anxiety and 0.73 in depression; item separation reliability = 0.98 in anxiety and 0.91 in depression). The difficulties of the four-point Likert scale used in the HADS were monotonically increased, which indicates no disordering response categories. No DIF items across male and female patients and across types of epilepsy were displayed in the HADS.ConclusionsThe HADS has promising psychometric properties on construct validity in people with epilepsy. Moreover, the additive item score is supported for calculating the cutoff.
|
|
| 36. |
- Liu, J., et al.
(author)
-
Demonstration of Low-Cost Uplink Transmission in a Coherent OCDMA PON Using Gain-Switched Fabry-Perot Lasers With External Injection
- 2010
-
In: IEEE Photonics Technology Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1041-1135 .- 1941-0174. ; 22:8, s. 583-585
-
Journal article (peer-reviewed)abstract
- We propose and demonstrate a simple and low-cost uplink transmission scheme for coherent optical code-division multiple access (OCDMA) passive optical networks (PONs), using gain-switched Fabry-Perot (GS-FP) lasers with external injection as local light sources at optical network units. Experimental results based on the two-user 1.25-Gb/s OCDMA system confirm the feasibility of this scheme. The system performance is compared with that of the OCDMA system using a conventional mode-locked laser (MLL). The auto-correlation peak to the maximum wing level (P/W) ratio is also given as the central wavelength of the GS-FP laser varies. The present low-cost scheme is highly preferable for OCDMA PON applications.
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
- Watson, Hannah, et al.
(author)
-
Transcriptome analysis of a wild bird reveals physiological responses to the urban environment
- 2017
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7, s. 44180-44180
-
Journal article (peer-reviewed)abstract
- Identifying the molecular basis of environmentally induced phenotypic variation presents exciting opportunities for furthering our understanding of how ecological processes and the environment can shape the phenotype. Urban and rural environments present free-living organisms with different challenges and opportunities, which have marked consequences for the phenotype, yet little is known about responses at the molecular level. We characterised transcriptomes from an urban and a rural population of great tits Parus major, demonstrating striking differences in gene expression profiles in both blood and liver tissues. Differentially expressed genes had functions related to immune and inflammatory responses, detoxification, protection against oxidative stress, lipid metabolism, and regulation of gene expression. Many genes linked to stress responses were expressed at higher levels in the urban birds, in accordance with our prediction that urban animals are exposed to greater environmental stress. This is one of the first studies to reveal transcriptional differences between urban- and rural-dwelling animals and suggests an important role for epigenetics in mediating environmentally induced physiological variation. The study provides valuable resources for developing further in-depth studies of the mechanisms driving phenotypic variation in the urban context at larger spatial and temporal scales.
|
|
| 40. |
- Zhong, J., et al.
(author)
-
Gaze and zoom controls for visual tracking
- 2013
-
In: Chinese Control Conf., CCC. - 9789881563835 ; , s. 811-816
-
Conference paper (peer-reviewed)abstract
- Visual tracking is widely used in many applications such as security surveillance, robot navigation and industrial inspection. In this paper gaze and zoom controls for visual tracking with a monocular camera are considered. The gaze control keeps the camera pointing to the centroid of a moving object of interest to keep the object centered in each image. The zoom control adjusts the camera focal length to preserve the object at a desired constant image size. Both gaze control and zoom control are explicitly designed with simple formulas. Simulation results validate the controls.
|
|
| 41. |
- Aad, G., et al.
(author)
-
- 2012
-
swepub:Mat__t (peer-reviewed)
|
|
