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Träfflista för sökning "WFRF:(Plesnila N) srt2:(2004)"

Search: WFRF:(Plesnila N) > (2004)

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  • Plesnila, N., et al. (author)
  • Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia
  • 2004
  • In: J Cereb Blood Flow Metab. ; 24:4, s. 458-66
  • Journal article (peer-reviewed)abstract
    • Signaling cascades associated with apoptosis contribute to cell death after focal cerebral ischemia. Cytochrome c release from mitochondria and the subsequent activation of caspases 9 and 3 are critical steps. Recently, a novel mitochondrial protein, apoptosis-inducing factor (AIF), has been implicated in caspase-independent programmed cell death following its translocation to the nucleus. We, therefore, addressed the question whether AIF also plays a role in cell death after focal cerebral ischemia. We detected AIF relocation from mitochondria to nucleus in primary cultured rat neurons 4 and 8 hours after 4 hours of oxygen/glucose deprivation. In ischemic mouse brain, AIF was detected within the nucleus 1 hour after reperfusion after 45 minutes occlusion of the middle cerebral artery. AIF translocation preceded cell death, occurred before or at the time when cytochrome c was released from mitochondria, and was evident within cells showing apoptosis-related DNA fragmentation. From these findings, we infer that AIF may be involved in neuronal cell death after focal cerebral ischemia and that caspase-independent signaling pathways downstream of mitochondria may play a role in apoptotic-like cell death after experimental stroke.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Culmsee, C (2)
Plesnila, N. (2)
Groger, M. (2)
Zhu, Changlian, 1964 (1)
Blomgren, Klas, 1963 (1)
Blomgren, K (1)
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Zhu, CL (1)
Moskowitz, M. A. (1)
Moskowitz, MA (1)
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University
University of Gothenburg (1)
Karolinska Institutet (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2004 (2)Undo refine

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