| 1. |
- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 9. |
- Bousquet, J., et al.
(author)
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ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
- 2016
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In: Clinical and Translational Allergy. - : Wiley. - 2045-7022. ; 6:1
-
Research review (peer-reviewed)abstract
- The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA - disseminated and implemented in over 70 countries globally - is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.
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| 10. |
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| 11. |
- Weiner, D. J., et al.
(author)
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
- 2017
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:7
-
Journal article (peer-reviewed)abstract
- Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.
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| 12. |
- Lunt, Daniel J., et al.
(author)
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The DeepMIP contribution to PMIP4 : experimental design for model simulations of the EECO, PETM, and pre-PETM (version 1.0)
- 2017
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In: Geoscientific Model Development. - : Copernicus GmbH. - 1991-959X .- 1991-9603. ; 10:2, s. 889-901
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Journal article (peer-reviewed)abstract
- Past warm periods provide an opportunity to evaluate climate models under extreme forcing scenarios, in particular high (>800 ppmv) atmospheric CO2 concentrations. Although a post hoc intercomparison of Eocene (similar to 50 Ma) climate model simulations and geological data has been carried out previously, models of past high-CO2 periods have never been evaluated in a consistent framework. Here, we present an experimental design for climate model simulations of three warm periods within the early Eocene and the latest Paleocene (the EECO, PETM, and pre-PETM). Together with the CMIP6 pre-industrial control and abrupt 4 x CO2 simulations, and additional sensitivity studies, these form the first phase of DeepMIP - the Deep-time Model Intercomparison Project, itself a group within the wider Paleo-climate Modelling Intercomparison Project (PMIP). The experimental design specifies and provides guidance on boundary conditions associated with palaeogeography, greenhouse gases, astronomical configuration, solar constant, land surface processes, and aerosols. Initial conditions, simulation length, and output variables are also specified. Finally, we explain how the geological data sets, which will be used to evaluate the simulations, will be developed.
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| 13. |
- Schjørring, O. L., et al.
(author)
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Intensive care doctors’ preferences for arterial oxygen tension levels in mechanically ventilated patients
- 2018
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In: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 62:10, s. 1443-1451
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Journal article (peer-reviewed)abstract
- Background: Oxygen is liberally administered in intensive care units (ICUs). Nevertheless, ICU doctors’ preferences for supplementing oxygen are inadequately described. The aim was to identify ICU doctors’ preferences for arterial oxygenation levels in mechanically ventilated adult ICU patients. Methods: In April to August 2016, an online multiple-choice 17-part-questionnaire was distributed to 1080 ICU doctors in seven Northern European countries. Repeated reminder e-mails were sent. The study ended in October 2016. Results: The response rate was 63%. When evaluating oxygenation 52% of respondents rated arterial oxygen tension (PaO2) the most important parameter; 24% a combination of PaO2 and arterial oxygen saturation (SaO2); and 23% preferred SaO2. Increasing, decreasing or not changing a default fraction of inspired oxygen of 0.50 showed preferences for a PaO2 around 8 kPa in patients with chronic obstructive pulmonary disease, a PaO2 around 10 kPa in patients with healthy lungs, acute respiratory distress syndrome or sepsis, and a PaO2 around 12 kPa in patients with cardiac or cerebral ischaemia. Eighty per cent would accept a PaO2 of 8 kPa or lower and 77% would accept a PaO2 of 12 kPa or higher in a clinical trial of oxygenation targets. Conclusion: Intensive care unit doctors preferred PaO2 to SaO2 in monitoring oxygen treatment when peripheral oxygen saturation was not included in the question. The identification of PaO2 as the preferred target and the thorough clarification of preferences are important when ascertaining optimal oxygenation targets. In particular when designing future clinical trials of higher vs lower oxygenation targets in ICU patients.
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| 14. |
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| 15. |
- Dragsted, L., et al.
(author)
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Metabolomic response to Nordic foods
- 2015
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In: Annals of Nutrition and Metabolism. - 0250-6807 .- 1421-9697. ; 67, s. 55-55
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Journal article (other academic/artistic)
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| 16. |
- Frandsen, K. E. H., et al.
(author)
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The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases
- 2016
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In: Nature Chemical Biology. - : Springer Science and Business Media LLC. - 1552-4450 .- 1552-4469. ; 12:4, s. 298-
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Journal article (peer-reviewed)abstract
- Lytic polysaccharide monooxygenases (LPMOs) are copper-containing enzymes that oxidatively break down recalcitrant polysaccharides such as cellulose and chitin. Since their discovery, LPMOs have become integral factors in the industrial utilization of biomass, especially in the sustainable generation of cellulosic bioethanol. We report here a structural determination of an LPMO-oligosaccharide complex, yielding detailed insights into the mechanism of action of these enzymes. Using a combination of structure and electron paramagnetic resonance spectroscopy, we reveal the means by which LPMOs interact with saccharide substrates. We further uncover electronic and structural features of the enzyme active site, showing how LPMOs orchestrate the reaction of oxygen with polysaccharide chains.
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| 17. |
- Hansen, Lea B.S., et al.
(author)
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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
- 2018
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 9:1
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Journal article (peer-reviewed)abstract
- © 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
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| 18. |
- Jensen, M. S., et al.
(author)
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Phospholipid flipping involves a central cavity in P4 ATPases
- 2017
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
-
Journal article (peer-reviewed)abstract
- P4 ATPase flippases translocate phospholipids across biomembranes, thus contributing to the establishment of transmembrane lipid asymmetry, a feature important for multiple cellular processes. The mechanism by which such phospholipid flipping occurs remains elusive as P4 ATPases transport a giant substrate very different from that of other P-type ATPases such as Na+/K+-and Ca2+-ATPases. Based on available crystal structures of cation-transporting P-type ATPases, we generated a structural model of the broad-specificity flippase ALA10. In this model, a cavity delimited by transmembrane segments TM3, TM4, and TM5 is present in the transmembrane domain at a similar position as the cation-binding region in related P-type ATPases. Docking of a phosphatidylcholine headgroup in silico showed that the cavity can accommodate a phospholipid headgroup, likely leaving the fatty acid tails in contact with the hydrophobic portion of the lipid bilayer. Mutagenesis data support this interpretation and suggests that two residues in TM4 (Y374 and F375) are important for coordination of the phospholipid headgroup. Our results point to a general mechanism of lipid translocation by P4 ATPases, which closely resembles that of cation-transporting pumps, through coordination of the hydrophilic portion of the substrate in a central membrane cavity.
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| 19. |
- Abulaiti, Yiming, et al.
(author)
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Performance of the ATLAS track reconstruction algorithms in dense environments in LHC Run 2
- 2017
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:10
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Journal article (peer-reviewed)abstract
- With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 TeV for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb(-1) of data collected by the ATLAS experiment and simulation of proton-proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13 TeV. The impact of charged-particle separations and multiplicities on the track reconstruction performance is discussed. The track reconstruction efficiency in the cores of jets with transverse momenta between 200 and 1600 GeV is quantified using a novel, data-driven, method. The method uses the energy loss, dE/dx, to identify pixel clusters originating from two charged particles. Of the charged particles creating these clusters, themeasured fraction that fail to be reconstructed is 0.061 +/- 0.006 (stat.) +/- 0.014 (syst.) and 0.093 +/- 0.017 (stat.) +/- 0.021 (syst.) for jet transverse momenta of 200-400 GeV and 1400-1600 GeV, respectively.
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| 20. |
- Abulaiti, Yiming, et al.
(author)
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Search for doubly charged Higgs boson production in multi-lepton final states with the ATLAS detector using proton-proton collisions at root s=13TeV
- 2018
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:3
-
Journal article (peer-reviewed)abstract
- A search for doubly charged Higgs bosons with pairs of prompt, isolated, highly energetic leptons with the same electric charge is presented. The search uses a proton-proton collision data sample at a centre-of-mass energy of 13 TeV corresponding to 36.1 fb(-1) of integrated luminosity recorded in 2015 and 2016 by the ATLAS detector at the LHC. This analysis focuses on the decays H-+/-+/- -> e(+/-)e(+/-), H-+/-+/- -> e(+/-)mu(+/-) and H-+/-+/- -> mu(+/-)mu(+/-), fitting the dilepton mass spectra in several exclusive signal regions. No significant evidence of a signal is observed and corresponding limits on the production cross-section and consequently a lower limit on m(H-+/-+/-) are derived at 95% confidence level. With l(+/-)l(+/-) = e(+/-)e(+/-)/mu(+/-)mu(+/-)/e(+/-)mu(+/-), the observed lower limit on the mass of a doubly charged Higgs boson only coupling to left-handed leptons varies from 770 to 870GeV (850GeV expected) for B(H-+/-+/- -> l(+/-)l(+/-)) = 100% and both the expected and observed mass limits are above 450GeV for B(H-+/-+/- -> l(+/-)l(+/-)) = 10% and any combination of partial branching ratios.
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| 21. |
- Abulaiti, Yiming, et al.
(author)
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Search for pair production of heavy vector-like quarks decaying to high-p(T) W bosons and b quarks in the lepton-plus-jets final state in pp collisions at root s=13 TeV with the ATLAS detector
- 2017
-
In: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :10
-
Journal article (peer-reviewed)abstract
- A search is presented for the pair production of heavy vector-like T quarks, primarily targeting the T quark decays to a W boson and a b-quark. The search is based on 36: 1 fb(-1) of pp collisions at root s = 13TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, including at least one b-tagged jet and a large-radius jet identified as originating from the hadronic decay of a high-momentum W boson. No significant deviation from the Standard Model expectation is observed in the reconstructed T mass distribution. The observed 95% confidence level lower limit on the T mass are 1350 GeV assuming 100% branching ratio to Wb. In the SU(2) singlet scenario, the lower mass limit is 1170 GeV. This search is also sensitive to a heavy vector-like B quark decaying to Wt and other final states. The results are thus reinterpreted to provide a 95% con fidence level lower limit on the B quark mass at 1250 GeV assuming 100% branching ratio to Wt; in the SU(2) singlet scenario, the limit is 1080 GeV. Mass limits on both T and B production are also set as a function of the decay branching ratios. The 100% branching ratio limits are found to be applicable to heavy vector-like Y and X production that decay to Wb and Wt, respectively.
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| 22. |
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| 23. |
- G., Aad, et al.
(author)
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Electron and photon performance measurements with the ATLAS detector using the 2015-2017 LHC proton-proton collision data
- 2019
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In: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 14:12
-
Journal article (peer-reviewed)abstract
- This paper describes the reconstruction of electrons and photons with the ATLAS detector, employed for measurements and searches exploiting the complete LHC Run 2 dataset. An improved energy clustering algorithm is introduced, and its implications for the measurement and identification of prompt electrons and photons are discussed in detail. Corrections and calibrations that affect performance, including energy calibration, identification and isolation efficiencies, and the measurement of the charge of reconstructed electron candidates are determined using up to 81 fb-1 of proton-proton collision data collected at √s = 13 TeV between 2015 and 2017. © 2019 CERN for the benefit of the ATLAS collaboration. Published by IOP Publishing Ltd on behalf of Sissa Medialab.
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| 24. |
- G., Aad, et al.
(author)
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Measurement of the cross-section and charge asymmetry of W bosons produced in proton–proton collisions at √s=8TeV with the ATLAS detector
- 2019
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:9
-
Journal article (peer-reviewed)abstract
- This paper presents measurements of the W+→ μ+ν and W-→ μ-ν cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton–proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2fb-1. The precision of the cross-section measurements varies between 0.8 and 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 25. |
- G., Aad, et al.
(author)
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Measurement of the production cross section for a Higgs boson in association with a vector boson in the H → WW⁎ → ℓνℓν channel in pp collisions at s=13 TeV with the ATLAS detector
- 2019
-
In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 798
-
Journal article (peer-reviewed)abstract
- A measurement of the Higgs boson production cross sections via associated WH and ZH production using H→WW⁎→ℓνℓν decays, where ℓ stands for either an electron or a muon, is presented. Results for combined WH and ZH production are also presented. The analysis uses events produced in proton–proton collisions collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The data correspond to an integrated luminosity of 36.1fb−1 recorded at a centre-of-mass energy of 13 TeV. The products of the H→WW⁎ branching fraction times the WH and ZH cross sections are measured to be 0.67−0.27 +0.31(stat.)−0.14 +0.18(syst.) pb and 0.54−0.24 +0.31(stat.)−0.07 +0.15(syst.) pb respectively, in agreement with the Standard Model predictions. © 2019 The Author(s)
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| 26. |
- G., Aad, et al.
(author)
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Measurements of top-quark pair differential and double-differential cross-sections in the ℓ +jets channel with pp collisions at √s=13 TeV using the ATLAS detector
- 2019
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:12
-
Journal article (peer-reviewed)abstract
- Single- and double-differential cross-section measurements are presented for the production of top-quark pairs, in the lepton + jets channel at particle and parton level. Two topologies, resolved and boosted, are considered and the results are presented as a function of several kinematic variables characterising the top and tt¯ system and jet multiplicities. The study was performed using data from pp collisions at centre-of-mass energy of 13 TeV collected in 2015 and 2016 by the ATLAS detector at the CERN Large Hadron Collider (LHC), corresponding to an integrated luminosity of 36fb-1. Due to the large tt¯ cross-section at the LHC, such measurements allow a detailed study of the properties of top-quark production and decay, enabling precision tests of several Monte Carlo generators and fixed-order Standard Model predictions. Overall, there is good agreement between the theoretical predictions and the data. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 27. |
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| 28. |
- G., Aad, et al.
(author)
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Search for a heavy charged boson in events with a charged lepton and missing transverse momentum from pp collisions at s =13 TeV with the ATLAS detector
- 2019
-
In: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 100:5
-
Journal article (peer-reviewed)abstract
- A search for a heavy charged-boson resonance decaying into a charged lepton (electron or muon) and a neutrino is reported. A data sample of 139 fb-1 of proton-proton collisions at s=13 TeV collected with the ATLAS detector at the LHC during 2015-2018 is used in the search. The observed transverse mass distribution computed from the lepton and missing transverse momenta is consistent with the distribution expected from the Standard Model, and upper limits on the cross section for pp→W′→ℓν are extracted (ℓ=e or μ). These vary between 1.3 pb and 0.05 fb depending on the resonance mass in the range between 0.15 and 7.0 TeV at 95% confidence level for the electron and muon channels combined. Gauge bosons with a mass below 6.0 and 5.1 TeV are excluded in the electron and muon channels, respectively, in a model with a resonance that has couplings to fermions identical to those of the Standard Model W boson. Cross-section limits are also provided for resonances with several fixed Γ/m values in the range between 1% and 15%. Model-independent limits are derived in single-bin signal regions defined by a varying minimum transverse mass threshold. The resulting visible cross-section upper limits range between 4.6 (15) pb and 22 (22) ab as the threshold increases from 130 (110) GeV to 5.1 (5.1) TeV in the electron (muon) channel. © 2019 CERN. © 2019 CERN, for the ATLAS Collaboration.
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| 29. |
- G., Aad, et al.
(author)
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Search for electroweak diboson production in association with a high-mass dijet system in semileptonic final states in pp collisions at s =13 TeV with the ATLAS detector
- 2019
-
In: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 100:3
-
Journal article (peer-reviewed)abstract
- This paper reports on a search for electroweak diboson (WW/WZ/ZZ) production in association with a high-mass dijet system, using data from proton-proton collisions at a center-of-mass energy of s=13 TeV. The data, corresponding to an integrated luminosity of 35.5 fb-1, were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The search is performed in final states in which one boson decays leptonically, and the other boson decays hadronically. The hadronically decaying W/Z boson is reconstructed as either two small-radius jets or one large-radius jet using jet substructure techniques. The electroweak production of WW/WZ/ZZ in association with two jets is measured with an observed (expected) significance of 2.7 (2.5) standard deviations, and the fiducial cross section is measured to be 45.1±8.6(stat.)-14.6+15.9(syst.) fb. © 2019 CERN.
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| 30. |
- Larsen, L. F., et al.
(author)
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No difference in human mast cells derived from peanut allergic versus non-allergic subjects
- 2018
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In: Immunity Inflammation and Disease. - : Wiley. - 2050-4527. ; 6:4, s. 416-427
-
Journal article (peer-reviewed)abstract
- Introduction Mast cells are the primary effector cells of allergy. This study aimed at characterizing human peripheral blood-derived mast cells (PBdMC) from peanut allergic and non-allergic subjects by investigating whether the molecular and stimulus-response profile of PBdMC discriminate between peanut allergic and healthy individuals. Methods Results PBdMC were generated from eight peanut allergic and 10 non-allergic subjects. The molecular profile (cell surface receptor expression) was assessed using flow cytometry. The stimulus-response profile (histamine release induced by secretagogues, secretion of cytokines/chemokines and changes in miRNA expression following anti-IgE activation) was carried out with histamine release test, luminex multiplex assay and miRNA arrays. Expression of activating receptors (Fc epsilon RI, CD48, CD88, CD117, and C3aR) on PBdMC was not different among peanut allergic and non-allergic subjects. Likewise, inhibitory receptors (CD32, CD200R, CD300a, and siglec-8) displayed comparable levels of expression. Both groups of PBdMC were unresponsive to substance P, compound 48/80 and C5a but released comparable levels of histamine when stimulated with anti-IgE and C3a. Interestingly, among the secreted cytokines/chemokines (IL-8, IL-10, IL-13, IL-23, IL-31, IL-37, MCP-1, VEGF, GM-CSF) PBdMC from peanut allergic subjects showed a different secretion pattern of IL-31 compared to non-allergic subjects. Investigating miRNA expression from resting or activated PBdMC revealed no significantly difference between peanut allergic and non-allergic subjects. Conclusion The molecular and stimulus-response profile revealed that PBdMC from peanut allergic subjects differently express IL-31 compared to non-allergic subjects. However, since only one altered parameter was found among 893 investigated, it is still questionable if the pathophysiological mechanisms of peanut allergy are revealed in PBdMC.
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| 31. |
- M., Aaboud, et al.
(author)
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Dijet azimuthal correlations and conditional yields in pp and p+Pb collisions at sNN=5.02TeV with the ATLAS detector
- 2019
-
In: Physical Review C. - 2469-9985 .- 2469-9993. ; 100:3
-
Journal article (peer-reviewed)abstract
- This paper presents a measurement of forward-forward and forward-central dijet azimuthal angular correlations and conditional yields in proton-proton (pp) and proton-lead (p+Pb) collisions as a probe of the nuclear gluon density in regions where the fraction of the average momentum per nucleon carried by the parton entering the hard scattering is low. In these regions, gluon saturation can modify the rapidly increasing parton distribution function of the gluon. The analysis utilizes 25pb-1 of pp data and 360μb-1 of p+Pb data, both at sNN=5.02 TeV, collected in 2015 and 2016, respectively, with the ATLAS detector at the Large Hadron Collider. The measurement is performed in the center-of-mass frame of the nucleon-nucleon system in the rapidity range between -4.0 and 4.0 using the two highest transverse-momentum jets in each event, with the highest transverse-momentum jet restricted to the forward rapidity range. No significant broadening of azimuthal angular correlations is observed for forward-forward or forward-central dijets in p+Pb compared to pp collisions. For forward-forward jet pairs in the proton-going direction, the ratio of conditional yields in p+Pb collisions to those in pp collisions is suppressed by approximately 20%, with no significant dependence on the transverse momentum of the dijet system. No modification of conditional yields is observed for forward-central dijets. © 2019 CERN.
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| 32. |
- M., Aaboud, et al.
(author)
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Measurement of the tt¯Z and tt¯W cross sections in proton-proton collisions at s=13 TeV with the ATLAS detector
- 2019
-
In: Physical Review D. - 2470-0010. ; 99:7
-
Journal article (peer-reviewed)abstract
- A measurement of the associated production of a top-quark pair (tt) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb-1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The ttZ and ttW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σttZ=0.95±0.08stat±0.10syst pb and σttW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the ttZ cross section is used to set constraints on effective field theory operators which modify the ttZ vertex. © 2019 CERN, for the ATLAS Collaboration.
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| 33. |
- M., Aaboud, et al.
(author)
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Search for heavy charged long-lived particles in the ATLAS detector in 36.1 fb-1 of proton-proton collision data at s =13 TeV
- 2019
-
In: Physical Review D. - 2470-0010. ; 99:9
-
Journal article (peer-reviewed)abstract
- A search for heavy charged long-lived particles is performed using a data sample of 36.1 fb-1 of proton-proton collisions at s=13 TeV collected by the ATLAS experiment at the Large Hadron Collider. The search is based on observables related to ionization energy loss and time of flight, which are sensitive to the velocity of heavy charged particles traveling significantly slower than the speed of light. Multiple search strategies for a wide range of lifetimes, corresponding to path lengths of a few meters, are defined as model independently as possible, by referencing several representative physics cases that yield long-lived particles within supersymmetric models, such as gluinos/squarks (R-hadrons), charginos and staus. No significant deviations from the expected Standard Model background are observed. Upper limits at 95% confidence level are provided on the production cross sections of long-lived R-hadrons as well as directly pair-produced staus and charginos. These results translate into lower limits on the masses of long-lived gluino, sbottom and stop R-hadrons, as well as staus and charginos of 2000, 1250, 1340, 430, and 1090 GeV, respectively. © 2019 CERN. for the ATLAS Collaboration. Published by the American Physical Society under the terms of the https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.
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| 34. |
- Milstead, David A., et al.
(author)
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Combination of Searches for Invisible Higgs Boson Decays with the ATLAS Experiment
- 2019
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In: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 122:23
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Journal article (peer-reviewed)abstract
- Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H→invisible decays where H is produced according to the standard model via vector boson fusion, Z(-)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1 fb-1 of pp collisions at a center-of-mass energy of s=13 TeV at the LHC. In combination with the results at s=7 and 8 TeV, an exclusion limit on the H→invisible branching ratio of 0.26(0.17-0.05+0.07) at 95% confidence level is observed (expected). © 2019 CERN.
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| 35. |
- Milstead, David A., et al.
(author)
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Electron reconstruction and identification in the ATLAS experiment using the 2015 and 2016 LHC proton–proton collision data at √s=13 TeV
- 2019
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:8
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Journal article (peer-reviewed)abstract
- Algorithms used for the reconstruction and identification of electrons in the central region of the ATLAS detector at the Large Hadron Collider (LHC) are presented in this paper; these algorithms are used in ATLAS physics analyses that involve electrons in the final state and which are based on the 2015 and 2016 proton–proton collision data produced by the LHC at s = 13 TeV. The performance of the electron reconstruction, identification, isolation, and charge identification algorithms is evaluated in data and in simulated samples using electrons from Z→ ee and J/ ψ→ ee decays. Typical examples of combinations of electron reconstruction, identification, and isolation operating points used in ATLAS physics analyses are shown. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 36. |
- Milstead, David A., et al.
(author)
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Search for heavy particles decaying into a top-quark pair in the fully hadronic final state in pp collisions at s =13 TeV with the ATLAS detector
- 2019
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In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 99:9
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Journal article (peer-reviewed)abstract
- A search for new particles decaying into a pair of top quarks is performed using proton-proton collision data recorded with the ATLAS detector at the Large Hadron Collider at a center-of-mass energy of s=13 TeV corresponding to an integrated luminosity of 36.1 fb-1. Events consistent with top-quark pair production and the fully hadronic decay mode of the top quarks are selected by requiring multiple high transverse momentum jets including those containing b-hadrons. Two analysis techniques, exploiting dedicated top-quark pair reconstruction in different kinematic regimes, are used to optimize the search sensitivity to new hypothetical particles over a wide mass range. The invariant mass distribution of the two reconstructed top-quark candidates is examined for resonant production of new particles with various spins and decay widths. No significant deviation from the Standard Model prediction is observed and limits are set on the production cross-section times branching fraction for new hypothetical Z′ bosons, dark-matter mediators, Kaluza-Klein gravitons and Kaluza-Klein gluons. By comparing with the predicted production cross sections, the Z′ boson in the topcolor-assisted-technicolor model is excluded for masses up to 3.1-3.6 TeV, the dark-matter mediators in a simplified framework are excluded in the mass ranges from 0.8 to 0.9 TeV and from 2.0 to 2.2 TeV, and the Kaluza-Klein gluon is excluded for masses up to 3.4 TeV, depending on the decay widths of the particles. © 2019 CERN, for the ATLAS Collaboration.
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| 37. |
- Aaboud, M, et al.
(author)
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ATLAS Collaboration
- 2017
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In: Nuclear Physics A. - : Elsevier. - 0375-9474 .- 1873-1554. ; 967, s. 942-964
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Journal article (peer-reviewed)
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| 38. |
- Aaboud, M, et al.
(author)
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ATLAS Collaboration
- 2019
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In: XXVIIth International Conference on Ultrarelativistic Nucleus–Nucleus Collisions (Quark Matter 2018). - 0375-9474. ; 982, s. 985-1009
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Conference paper (peer-reviewed)
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| 39. |
- Aaboud, M, et al.
(author)
-
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ⁎ → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- 2018
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In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 786, s. 114-133
-
Journal article (peer-reviewed)abstract
- A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ⁎→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions. © 2018 The Author(s)
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| 40. |
- Aaboud, M, et al.
(author)
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Constraints on mediator-based dark matter and scalar dark energy models using √s = 13 TeV pp collision data collected by the ATLAS detector
- 2019
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In: Journal of High Energy Physics. - 1029-8479. ; 2019:5
-
Journal article (peer-reviewed)abstract
- Constraints on selected mediator-based dark matter models and a scalar dark energy model using up to 37 fb−1s = 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015-2016 are summarised in this paper. The results of experimental searches in a variety of final states are interpreted in terms of a set of spin-1 and spin-0 single-mediator dark matter simplified models and a second set of models involving an extended Higgs sector plus an additional vector or pseudo-scalar mediator. The searches considered in this paper constrain spin-1 leptophobic and leptophilic mediators, spin-0 colour-neutral and colour-charged mediators and vector or pseudo-scalar mediators embedded in extended Higgs sector models. In this case, also s = 8 TeV pp collision data are used for the interpretation of the results. The results are also interpreted for the first time in terms of light scalar particles that could contribute to the accelerating expansion of the universe (dark energy).[Figure not available: see fulltext.]. © 2019, The Author(s).
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| 41. |
- Aaboud, M, et al.
(author)
-
Measurement of colour flow using jet-pull observables in tt¯ events with the ATLAS experiment at √s=13TeV
- 2018
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:10
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Journal article (peer-reviewed)abstract
- Previous studies have shown that weighted angular moments derived from jet constituents encode the colour connections between partons that seed the jets. This paper presents measurements of two such distributions, the jet-pull angle and jet-pull magnitude, both of which are derived from the jet-pull angular moment. The measurement is performed in tt¯ events with one leptonically decaying W boson and one hadronically decaying W boson, using 36.1fb-1 of pp collision data recorded by the ATLAS detector at s=13TeV delivered by the Large Hadron Collider. The observables are measured for two dijet systems, corresponding to the colour-connected daughters of the W boson and the two b-jets from the top-quark decays, which are not expected to be colour connected. To allow the comparison of the measured distributions to colour model predictions, the measured distributions are unfolded to particle level, after correcting for experimental effects introduced by the detector. While good agreement can be found for some combinations of predictions and observables, none of the predictions describes the data well across all observables. © 2018, CERN for the benefit of the ATLAS collaboration.
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| 42. |
- Aaboud, M, et al.
(author)
-
Measurement of fiducial and differential W+W- production cross-sections at √s=13 TeV with the ATLAS detector
- 2019
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:10
-
Journal article (peer-reviewed)abstract
- A measurement of fiducial and differential cross-sections for W+W- production in proton–proton collisions at s=13 TeV with the ATLAS experiment at the Large Hadron Collider using data corresponding to an integrated luminosity of 36.1 fb - 1 is presented. Events with one electron and one muon are selected, corresponding to the decay of the diboson system as WW→ e±νμ∓ν. To suppress top-quark background, events containing jets with a transverse momentum exceeding 35 GeV are not included in the measurement phase space. The fiducial cross-section, six differential distributions and the cross-section as a function of the jet-veto transverse momentum threshold are measured and compared with several theoretical predictions. Constraints on anomalous electroweak gauge boson self-interactions are also presented in the framework of a dimension-six effective field theory. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 43. |
- Aaboud, M, et al.
(author)
-
Measurement of lepton differential distributions and the top quark mass in tt¯ production in pp collisions at √s=8 TeV with the ATLAS detector
- 2017
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 77:11
-
Journal article (peer-reviewed)abstract
- This paper presents single lepton and dilepton kinematic distributions measured in dileptonic tt¯ events produced in 20.2fb - 1 of s=8 TeV pp collisions recorded by the ATLAS experiment at the LHC. Both absolute and normalised differential cross-sections are measured, using events with an opposite-charge eμ pair and one or two b-tagged jets. The cross-sections are measured in a fiducial region corresponding to the detector acceptance for leptons, and are compared to the predictions from a variety of Monte Carlo event generators, as well as fixed-order QCD calculations, exploring the sensitivity of the cross-sections to the gluon parton distribution function. Some of the distributions are also sensitive to the top quark pole mass; a combined fit of NLO fixed-order predictions to all the measured distributions yields a top quark mass value of mtpole=173.2±0.9±0.8±1.2 GeV, where the three uncertainties arise from data statistics, experimental systematics, and theoretical sources. © 2017, CERN for the benefit of the ATLAS collaboration.
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| 44. |
- Aaboud, M, et al.
(author)
-
Measurement of prompt photon production in sNN=8.16 TeV p + Pb collisions with ATLAS
- 2019
-
In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 796, s. 230-252
-
Journal article (peer-reviewed)abstract
- The inclusive production rates of isolated, prompt photons in p+Pb collisions at sNN=8.16 TeV are studied with the ATLAS detector at the Large Hadron Collider using a dataset with an integrated luminosity of 165 nb−1 recorded in 2016. The cross-section and nuclear modification factor RpPb are measured as a function of photon transverse energy from 20 GeV to 550 GeV and in three nucleon–nucleon centre-of-mass pseudorapidity regions, (−2.83,−2.02), (−1.84,0.91), and (1.09,1.90). The cross-section and RpPb values are compared with the results of a next-to-leading-order perturbative QCD calculation, with and without nuclear parton distribution function modifications, and with expectations based on a model of the energy loss of partons prior to the hard scattering. The data disfavour a large amount of energy loss and provide new constraints on the parton densities in nuclei. © 2019 The Author
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| 45. |
- Aaboud, M, et al.
(author)
-
Measurement of the azimuthal anisotropy of charged particles produced in √sNN = 5.02 TeV Pb+Pb collisions with the ATLAS detector
- 2018
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 78:12
-
Journal article (peer-reviewed)abstract
- Measurements of the azimuthal anisotropy in lead–lead collisions at sNN = 5.02 TeV are presented using a data sample corresponding to 0.49 nb - 1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5 < pT< 60 GeV, the pseudorapidity, | η| < 2.5, and the collision centrality 0–80%. Results from different methods are compared and discussed in the context of previous and recent measurements in Pb+Pb collisions at sNN = 2.76 TeV and 5.02 TeV. In particular, the shape of the pTdependence of elliptic or triangular flow harmonics is observed to be very similar at different centralities after scaling the vn and pTvalues by constant factors over the centrality interval 0–60% and the pTrange 0.5 < pT< 5 GeV. © 2018, CERN for the benefit of the ATLAS collaboration.
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| 46. |
- Aaboud, M, et al.
(author)
-
Measurement of the Higgs boson mass in the H → ZZ⁎ → 4ℓ and H → γγ channels with s=13 TeV pp collisions using the ATLAS detector
- 2018
-
In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 784, s. 345-366
-
Journal article (peer-reviewed)abstract
- The mass of the Higgs boson is measured in the H→ZZ⁎→4ℓ and in the H→γγ decay channels with 36.1 fb−1 of proton–proton collision data from the Large Hadron Collider at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector in 2015 and 2016. The measured value in the H→ZZ⁎→4ℓ channel is mH ZZ⁎=124.79±0.37GeV, while the measured value in the H→γγ channel is mH γγ=124.93±0.40GeV. Combining these results with the ATLAS measurement based on 7 and 8 TeV proton–proton collision data yields a Higgs boson mass of mH=124.97±0.24GeV. © 2018 The Author
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| 47. |
- Aaboud, M, et al.
(author)
-
Measurement of the top quark mass in the tt¯ → lepton+jets channel from √s=8 TeV ATLAS data and combination with previous results
- 2019
-
In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:4
-
Journal article (peer-reviewed)abstract
- The top quark mass is measured using a template method in the tt¯ → lepton + jets channel (lepton is e or μ) using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton–proton centre-of-mass energy of s=8 TeV and correspond to an integrated luminosity of 20.2 fb - 1 . The tt¯ → lepton + jets channel is characterized by the presence of a charged lepton, a neutrino and four jets, two of which originate from bottom quarks (b). Exploiting a three-dimensional template technique, the top quark mass is determined together with a global jet energy scale factor and a relative b-to-light-jet energy scale factor. The mass of the top quark is measured to be mtop=172.08±0.39(stat)±0.82(syst) GeV. A combination with previous ATLAS m top measurements gives mtop=172.69±0.25(stat)±0.41(syst) GeV. © 2019, CERN for the benefit of the ATLAS collaboration.
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| 48. |
- Aaboud, M, et al.
(author)
-
Measurement of ZZ production in the ℓℓνν final state with the ATLAS detector in pp collisions at √s = 13 TeV
- 2019
-
In: Journal of High Energy Physics. - 1029-8479. ; 2019:10
-
Journal article (peer-reviewed)abstract
- This paper presents a measurement of ZZ production with the ATLAS detector at the Large Hadron Collider. The measurement is carried out in the final state with two charged leptons and two neutrinos, using data collected during 2015 and 2016 in pp collisions at s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. The integrated cross-sections in the total and fiducial phase spaces are measured with an uncertainty of 7% and compared with Standard Model predictions, and differential measurements in the fiducial phase space are reported. No significant deviations from the Standard Model predictions are observed, and stringent constraints are placed on anomalous couplings corresponding to neutral triple gauge-boson interactions. [Figure not available: see fulltext.]. © 2019, The Author(s).
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| 49. |
- Aaboud, M, et al.
(author)
-
Measurements of b-jet tagging efficiency with the ATLAS detector using tt¯ events at √s=13 TeV
- 2018
-
In: Journal of High Energy Physics. - 1029-8479. ; 2018:8
-
Journal article (peer-reviewed)abstract
- The efficiency to identify jets containing b-hadrons (b-jets) is measured using a high purity sample of dileptonic top quark-antiquark pairs (tt¯) selected from the 36.1 fb−1 of data collected by the ATLAS detector in 2015 and 2016 from proton-proton collisions produced by the Large Hadron Collider at a centre-of-mass energy s=13 TeV. Two methods are used to extract the efficiency from tt¯ events, a combinatorial likelihood approach and a tag-and-probe method. A boosted decision tree, not using b-tagging information, is used to select events in which two b-jets are present, which reduces the dominant uncertainty in the modelling of the flavour of the jets. The efficiency is extracted for jets in a transverse momentum range from 20 to 300 GeV, with data-to-simulation scale factors calculated by comparing the efficiency measured using collision data to that predicted by the simulation. The two methods give compatible results, and achieve a similar level of precision, measuring data-to-simulation scale factors close to unity with uncertainties ranging from 2% to 12% depending on the jet transverse momentum. © 2018, The Author(s).
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| 50. |
- Aaboud, M, et al.
(author)
-
Measurements of gluon–gluon fusion and vector-boson fusion Higgs boson production cross-sections in the H → WW⁎ → eνμν decay channel in pp collisions at √s=13TeV with the ATLAS detector
- 2019
-
In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 789, s. 508-529
-
Journal article (peer-reviewed)abstract
- Higgs boson production cross-sections in proton–proton collisions are measured in the H→WW⁎→eνμν decay channel. The proton–proton collision data were produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector in 2015 and 2016, corresponding to an integrated luminosity of 36.1fb−1. The product of the H→WW⁎ branching fraction times the gluon–gluon fusion and vector-boson fusion cross-sections are measured to be 11.4−1.1 +1.2(stat.)−1.7 +1.8(syst.)pb and 0.50−0.22 +0.24(stat.)±0.17(syst.)pb, respectively, in agreement with Standard Model predictions. © 2019 The Author
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