SwePub - search: WFRF:(Rees A. P.)

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1.	Thomas, HS, et al. (author) 2019 swepub:Mat__t
2.	Bhangu, A, et al. (author) Mortality of emergency abdominal surgery in high-, middle- and low-income countries 2016 In: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 103:8, s. 971-988 Journal article (peer-reviewed)
3.	Aartsen, M. G., et al. (author) Determining neutrino oscillation parameters from atmospheric muon neutrino disappearance with three years of IceCube DeepCore data 2015 In: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:7 Journal article (peer-reviewed)abstract We present a measurement of neutrino oscillations via atmospheric muon neutrino disappearance with three years of data of the completed IceCube neutrino detector. DeepCore, a region of denser IceCube instrumentation, enables the detection and reconstruction of atmospheric muon neutrinos between 10 and 100 GeV, where a strong disappearance signal is expected. The IceCube detector volume surrounding DeepCore is used as a veto region to suppress the atmospheric muon background. Neutrino events are selected where the detected Cherenkov photons of the secondary particles minimally scatter, and the neutrino energy and arrival direction are reconstructed. Both variables are used to obtain the neutrino oscillation parameters from the data, with the best fit given by Delta m(32)(2) = 2.72(-0.20)(+0.19) x 10(-3) eV(2) and sin(2)theta(23) = 0.53(-0.12)(+0.09) (normal mass ordering assumed). The results are compatible, and comparable in precision, to those of dedicated oscillation experiments.
4.	Aartsen, M. G., et al. (author) Development of a general analysis and unfolding scheme and its application to measure the energy spectrum of atmospheric neutrinos with IceCube 2015 In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:3 Journal article (peer-reviewed)abstract We present the development and application of a generic analysis scheme for the measurement of neutrino spectra with the IceCube detector. This scheme is based on regularized unfolding, preceded by an event selection which uses a Minimum Redundancy Maximum Relevance algorithm to select the relevant variables and a random forest for the classification of events. The analysis has been developed using IceCube data from the 59-string configuration of the detector. 27,771 neutrino candidates were detected in 346 days of livetime. A rejection of 99.9999 % of the atmospheric muon background is achieved. The energy spectrum of the atmospheric neutrino flux is obtained using the TRUEE unfolding program. The unfolded spectrum of atmospheric muon neutrinos covers an energy range from 100 GeV to 1 PeV. Compared to the previous measurement using the detector in the 40-string configuration, the analysis presented here, extends the upper end of the atmospheric neutrino spectrum by more than a factor of two, reaching an energy region that has not been previously accessed by spectral measurements.
5.	Aartsen, M. G., et al. (author) Atmospheric and astrophysical neutrinos above 1 TeV interacting in IceCube 2015 In: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:2, s. 022001- Journal article (peer-reviewed)abstract The IceCube Neutrino Observatory was designed primarily to search for high-energy (TeV-PeV) neutLrinos produced in distant astrophysical objects. A search for. greater than or similar to 100 TeV neutrinos interacting inside the instrumented volume has recently provided evidence for an isotropic flux of such neutrinos. At lower energies, IceCube collects large numbers of neutrinos from the weak decays of mesons in cosmic-ray air showers. Here we present the results of a search for neutrino interactions inside IceCube's instrumented volume between 1 TeV and 1 PeV in 641 days of data taken from 2010-2012, lowering the energy threshold for neutrinos from the southern sky below 10 TeV for the first time, far below the threshold of the previous high-energy analysis. Astrophysical neutrinos remain the dominant component in the southern sky down to a deposited energy of 10 TeV. From these data we derive new constraints on the diffuse astrophysical neutrino spectrum, Phi(v) = 2.06(-0.3)(+0.4) x 10(-18) (E-v = 10(5) GeV)-2.46 +/- 0.12GeV-1 cm(-2) sr(-1) s(-1) for 25 TeV < E-v < 1.4 PeV, as well as the strongest upper limit yet on the flux of neutrinos from charmed-meson decay in the atmosphere, 1.52 times the benchmark theoretical prediction used in previous IceCube results at 90% confidence.
6.	Aartsen, M. G., et al. (author) Multipole analysis of IceCube data to search for dark matter accumulated in the Galactic halo 2015 In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:1 Journal article (peer-reviewed)abstract Dark matter which is bound in the Galactic halo might self-annihilate and produce a flux of stable final state particles, e. g. high energy neutrinos. These neutrinos can be detected with IceCube, a cubic-kilometer sized Cherenkov detector. Given IceCube's large field of view, a characteristic anisotropy of the additional neutrino flux is expected. In this paper we describe a multipole method to search for such a large-scale anisotropy in IceCube data. This method uses the expansion coefficients of a multipole expansion of neutrino arrival directions and incorporates signal-specific weights for each expansion coefficient. We apply the technique to a high-purity muon neutrino sample from the Northern Hemisphere. The final result is compatible with the null-hypothesis. As no signal was observed, we present limits on the self-annihilation cross-section averaged over the relative velocity distribution down to 1.9x10(-23) cm(3) s(-1) for a dark matter particle mass of 700-1,000 GeV and direct annihilation into nu(nu) over bar. The resulting exclusion limits come close to exclusion limits from gamma-ray experiments, that focus on the outer Galactic halo, for high dark matter masses of a few TeV and hard annihilation channels.
7.	Aartsen, M. G., et al. (author) Search for Prompt Neutrino Emission from Gamma-Ray Bursts with IceCube 2015 In: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 805:1 Journal article (peer-reviewed)abstract We present constraints derived from a search of four years of IceCube data for a prompt neutrino flux from gammaray bursts (GRBs). A single low-significance neutrino, compatible with the atmospheric neutrino background, was found in coincidence with one of the 506 observed bursts. Although GRBs have been proposed as candidate sources for ultra-high-energy cosmic rays, our limits on the neutrino flux disfavor much of the parameter space for the latest models. We also find that no more than similar to 1% of the recently observed astrophysical neutrino flux consists of prompt emission from GRBs that are potentially observable by existing satellites.
8.	Aartsen, M. G., et al. (author) Flavor Ratio of Astrophysical Neutrinos above 35 TeV in IceCube 2015 In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:17 Journal article (peer-reviewed)abstract A diffuse flux of astrophysical neutrinos above 100 TeV has been observed at the IceCube Neutrino Observatory. Here we extend this analysis to probe the astrophysical flux down to 35 TeV and analyze its flavor composition by classifying events as showers or tracks. Taking advantage of lower atmospheric backgrounds for showerlike events, we obtain a shower-biased sample containing 129 showers and 8 tracks collected in three years from 2010 to 2013. We demonstrate consistency with the (f(e) : f(mu) : f(tau))(circle plus) approximate to (1 : 1 : 1)(circle plus) flavor ratio at Earth commonly expected from the averaged oscillations of neutrinos produced by pion decay in distant astrophysical sources. Limits are placed on nonstandard flavor compositions that cannot be produced by averaged neutrino oscillations but could arise in exotic physics scenarios. A maximally tracklike composition of (0 : 1 : 0)(circle plus) is excluded at 3.3 sigma, and a purely showerlike composition of (1 : 0 : 0)(circle plus) is excluded at 2.3 sigma.
9.	Aartsen, M. G., et al. (author) Searches for small-scale anisotropies from neutrino point sources with three years of IceCube data 2015 In: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 66, s. 39-52 Journal article (peer-reviewed)abstract Recently, IceCube found evidence for a diffuse signal of astrophysical neutrinos in an energy range of similar to 60 TeV to the PeV-scale [1]. The origin of those events, being a key to understanding the origin of cosmic rays, is still an unsolved question. So far, analyses have not succeeded to resolve the diffuse signal into point-like sources. Searches including a maximum-likelihood-ratio test, based on the reconstructed directions and energies of the detected down- and up-going neutrino candidates, were also performed on IceCube data leading to the exclusion of bright point sources. In this paper, we present two methods to search for faint neutrino point sources in three years of IceCube data, taken between 2008 and 2011. The first method is an autocorrelation test, applied separately to the northern and southern sky. The second method is a multipole analysis, which expands the measured data in the northern hemisphere into spherical harmonics and uses the resulting expansion coefficients to separate signal from background. With both methods, the results are consistent with the background expectation with a slightly more sparse spatial distribution, corresponding to an underfluctuation. Depending on the assumed number of sources, the resulting upper limit on the flux per source in the northern hemisphere for an E-2 energy spectrum ranges from similar to 1.5. 10(-8) GeV/cm(2) s(-1), in the case of one assumed source, to similar to 4. 10(-10) GeV/cm(2) s(-1), in the case of 3500 assumed sources.
10.	Bancroft, EK, et al. (author) Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations 2019 In: BJU international. - : Wiley. - 1464-410X .- 1464-4096. ; 123:2, s. 284-292 Journal article (peer-reviewed)
11.	Aartsen, M. G., et al. (author) SEARCHES FOR TIME-DEPENDENT NEUTRINO SOURCES WITH ICECUBE DATA FROM 2008 TO 2012 2015 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 807:1 Journal article (peer-reviewed)abstract In this paper searches for flaring astrophysical neutrino sources and sources with periodic emission with the IceCube neutrino telescope are presented. In contrast to time-integrated searches, where steady emission is assumed, the analyses presented here look for a time-dependent signal of neutrinos using the information from the neutrino arrival times to enhance the discovery potential. A search was performed for correlations between neutrino arrival times and directions, as well as neutrino emission following time-dependent light curves, sporadic emission, or periodicities of candidate sources. These include active galactic nuclei, soft gamma-ray repeaters, supernova remnants hosting pulsars, microquasars, and X-ray binaries. The work presented here updates and extends previously published results to a longer period that covers 4 years. of data from 2008 April 5 to 2012 May 16, including the first year of operation of the completed 86 string detector. The analyses did not find any significant time-dependent point sources of neutrinos, and the results were used to set upper limits on the neutrino flux from source candidates.
12.	Marconi, A., et al. (author) ELT-HIRES, the high resolution spectrograph for the ELT : results from the Phase A study 2018 In: GROUND-BASED AND AIRBORNE INSTRUMENTATION FOR ASTRONOMY VII. - : SPIE-INT SOC OPTICAL ENGINEERING. - 9781510619586 Conference paper (peer-reviewed)abstract We present the results from the phase A study of ELT-HIRES, an optical-infrared High Resolution Spectrograph for ELT, which has just been completed by a consortium of 30 institutes from 12 countries forming a team of about 200 scientists and engineers. The top science cases of ELT-HIRES will be the detection of life signatures from exoplanet atmospheres, tests on the stability of Nature's fundamental couplings, the direct detection of the cosmic acceleration. However, the science requirements of these science cases enable many other groundbreaking science cases. The baseline design, which allows to fulfil the top science cases, consists in a modular fiber fed cross-dispersed echelle spectrograph with two ultra-stable spectral arms providing a simultaneous spectral range of 0.4-1.8 pm at a spectral resolution of 100, 000. The fiber-feeding allows ELT-HIRES to have several, interchangeable observing modes including a SCAO module and a small diffraction-limited IFU.
13.	Ademuyiwa, Adesoji O., et al. (author) Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries 2016 In: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4 Journal article (peer-reviewed)abstract Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
14.	Balwani, M, et al. (author) ENVISION, a phase 3 study to evaluate efficacy and safety of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1, in acute hepatic porphyria patients 2019 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 70:1, s. E81-E82 Conference paper (other academic/artistic)
15.	Gouya, L, et al. (author) Acute hepatic porphyria disease manifestations and daily life impacts in EXPLORE international, prospective, natural history study 2019 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 70:1, s. E589-E590 Conference paper (other academic/artistic)
16.	Gouya, L, et al. (author) EXPLORE: A prospective, multinational natural history study of patients with acute hepatic porphyria with recurrent attacks 2018 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 33, s. S192-S192 Conference paper (other academic/artistic)
17.	Sardh, E, et al. (author) Management of acute hepatic porphyria attacks in europe and united states: EXPLORE international, prospective, natural history study 2019 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 70:1, s. E588-E588 Conference paper (other academic/artistic)
18.	Wunderer, C. B., et al. (author) Detector developments at DESY 2016 In: Journal of Synchrotron Radiation. - 0909-0495 .- 1600-5775. ; 23, s. 111-117 Journal article (peer-reviewed)abstract With the increased brilliance of state-of-the-art synchrotron radiation sources and the advent of free-electron lasers (FELs) enabling revolutionary science with EUV to X-ray photons comes an urgent need for suitable photon imaging detectors. Requirements include high frame rates, very large dynamic range, single-photon sensitivity with low probability of false positives and (multi)-megapixels. At DESY, one ongoing development project-in collaboration with RAL/STFC, Elettra Sincrotrone Trieste, Diamond, and Pohang Accelerator Laboratory-is the CMOS-based soft X-ray imager PERCIVAL. PERCIVAL is a monolithic active-pixel sensor back-thinned to access its primary energy range of 250 eV to 1 keV with target efficiencies above 90%. According to preliminary specifications, the roughly 10 cm × 10 cm, 3.5k × 3.7k monolithic sensor will operate at frame rates up to 120 Hz (commensurate with most FELs) and use multiple gains within 27 μm pixels to measure 1 to ∼ 100000 (500 eV) simultaneously arriving photons. DESY is also leading the development of the AGIPD, a high-speed detector based on hybrid pixel technology intended for use at the European XFEL. This system is being developed in collaboration with PSI, University of Hamburg, and University of Bonn. The AGIPD allows singlepulse imaging at 4.5 MHz frame rate into a 352-frame buffer, with a dynamic range allowing single-photon detection and detection of more than 10000 photons at 12.4 keV in the same image. Modules of 65k pixels each are configured to make up (multi)megapixel cameras. This review describes the AGIPD and the PERCIVAL concepts and systems, including some recent results and a summary of their current status. It also gives a short overview over other FEL-relevant developments where the Photon Science Detector Group at DESY is involved. © 2016 International Union of Crystallography.
19.	Anderson, K, et al. (author) Disease Characteristics of Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial 2019 In: AMERICAN JOURNAL OF GASTROENTEROLOGY. - : Ovid Technologies (Wolters Kluwer Health). - 0002-9270 .- 1572-0241. ; 114, s. S578-S578 Conference paper (other academic/artistic)
20.	Bouchet, P., et al. (author) The Mid-Infrared Instrument for the James Webb Space Telescope, III: MIRIM, The MIRI Imager 2015 In: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 127:953, s. 612-622 Journal article (peer-reviewed)abstract In this article, we describe the Mid-Infrared Imager Module (MIRIM), which provides broadband imaging in the 5-27 mu m wavelength range for the James Webb Space Telescope. The imager has a 0 ''.11 pixel scale and a total unobstructed view of 74 '' x 113 '' The remainder of its nominal 113 '' x 113 '' field is occupied by the coronagraphs and the low-resolution spectrometer. We present the instrument optical and mechanical design. We show that the test data, as measured during the test campaigns undertaken at CEA-Saclay, at the Rutherford Appleton Laboratory, and at the NASA Goddard Space Flight Center, indicate that the instrument complies with its design requirements and goals. We also discuss the operational requirements (multiple dithers and exposures) needed for optimal scientific utilization of the MIRIM.
21.	Bowden, John A., et al. (author) Harmonizing lipidomics : NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma 2017 In: Journal of Lipid Research. - 0022-2275 .- 1539-7262. ; 58:12, s. 2275-2288 Journal article (peer-reviewed)abstract As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950-Metabolites in Frozen Human Plasma, a commercially available reference material. The interlaboratory study comprised 31 diverse laboratories, with each laboratory using a different lipidomics workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates and associated uncertainties were determined for 339 of these lipids measured at the sum composition level by five or more participating laboratories. These evaluated lipids detected in SRM 1950 serve as community-wide benchmarks for intra-and interlaboratory quality control and method validation. These analyses were performed using nonstandardized laboratory-independent workflows. The consensus locations were also compared with a previous examination of SRM 1950 by the LIPID MAPS consortium.jlr While the central theme of the interlaboratory study was to provide values to help harmonize lipids, lipid mediators, and precursor measurements across the community, it was also initiated to stimulate a discussion regarding areas in need of improvement.
22.	Hartley, D. J., et al. (author) Persistence of collective behavior at high spin in the N=88 nucleus Tb-153 2015 In: Physical Review C (Nuclear Physics). - 0556-2813. ; 91:5 Journal article (peer-reviewed)abstract Excited states in the N = 88 nucleus Tb-153 were observed up to spin similar to 40 in an experiment utilizing the Gammasphere array. The Tb-153 states were populated in a weak alpha 4n evaporation channel of the Cl-37 + Sn-124 reaction. Two previously known sequences were extended to higher spins, and a new decoupled structure was identified. The pi h(11/2) band was observed in the spin region where other N = 88 isotopes exhibit effects of prolate to oblate shape changes leading to band termination along the yrast line, whereas Tb-153 displays a persistent collective behavior. However, minor perturbations of the very highest state in both signatures of this h(11/2) band are observed, which perhaps signal the start of the transition towards band termination.
23.	Paul, E. S., et al. (author) Recent Results at Ultrahigh Spin: Terminating States and Beyond in Mass 160 Rare-earth Nuclei 2015 In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 46:3, s. 487-496 Journal article (peer-reviewed)abstract A classic region of band termination at high spin occurs in rare-earth nuclei with around ten valence nucleons above the Gd-146 closed core. Results are presented here for such non-collective oblate (gamma = 60 degrees) terminating states in odd-Z Ho-155, odd-odd Ho-156, and even-even Er-156, where they are compared with neighbouring nuclei. In addition to these particularly favoured states, the occurrence of collective triaxial strongly deformed (TSD) bands, bypassing the terminating states and extending to over 65 (h) over bar, is reviewed.
24.	Rees, J. M., et al. (author) High-spin terminating states in the N=88 Ho-155 and Er-156 isotones 2015 In: Physical Review C (Nuclear Physics). - 0556-2813. ; 91:5 Journal article (peer-reviewed)abstract The Sn-124(Cl-37, 6n gamma) fusion-evaporation reaction at a bombarding energy of 180 MeV has been used to significantly extend the excitation level scheme of Ho-155(67)88. The collective rotational behavior of this nucleus breaks down above spin I similar to 30 and a fully aligned noncollective (band terminating) state has been identified at I-pi = 79/2(-). Comparison with cranked Nilsson-Strutinsky calculations also provides evidence for core-excited noncollective states at I-pi = 87/2(-) and (89/2(+)) involving particle-hole excitations across the Z = 64 shell gap. A similar core-excited state in Er-156(68)88 at I-pi = (46(+)) is also presented.
25.	Bissell, DM, et al. (author) ENVISION, A PHASE 3 STUDY OF SAFETY AND EFFICACY OF GIVOSIRAN, AN INVESTIGATIONAL RNAi THERAPEUTIC, IN ACUTE HEPATIC PORPHYRIA PATIENTS 2019 In: HEPATOLOGY. - 0270-9139. ; 70, s. 100A-101A Conference paper (other academic/artistic)
26.	Bonkovsky, HL, et al. (author) Explore: A Prospective, Multinational Natural History Study of Acute Hepatic Porphyria Patients with Recurrent Attacks 2018 In: HEPATOLOGY. - 0270-9139. ; 68, s. 723A-724A Conference paper (other academic/artistic)
27.	Singh, T, et al. (author) Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders 2016 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 19:4, s. 571- Journal article (peer-reviewed)
28.	Sardh, E, et al. (author) Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria 2019 In: The New England journal of medicine. - 1533-4406. ; 380:6, s. 549-558 Journal article (peer-reviewed)
29.	Anderson, KE, et al. (author) Phase 1/2 and Open Label Extension Studies of Givosiran an Investigational RNAi Therapeutic, in Patients with Acute Intermittent Porphyria 2018 In: HEPATOLOGY. - 0270-9139. ; 68, s. 50A-51A Conference paper (other academic/artistic)
30.	Bissell, M, et al. (author) A phase 1/2 open-label extension study of givosiran, an investigational RNAi therapeutic, in patients with acute intermittent porphyria 2019 In: EUROPEAN JOURNAL OF NEUROLOGY. - 1351-5101. ; 26, s. 52-52 Conference paper (other academic/artistic)
31.	Marras, A., et al. (author) Experimental characterization of the PERCIVAL soft X-ray detector 2016 In: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781467398626 Conference paper (other academic/artistic)abstract Considerable interest has been manifested for the use of high-brilliance X-ray synchrotron sources and X-ray Free-Electron Lasers for the investigation of samples.
32.	Pardinas, AF, et al. (author) Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection 2018 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 50:3, s. 381- Journal article (peer-reviewed)
33.	Phillips, J, et al. (author) PHASE 1/2, RANDOMIZED, PLACEBO CONTROLLED AND OPEN LABEL EXTENSION STUDIES OF GIVOSIRAN AN INVESTIGATIONAL RNA INTERFERENCE (RNAI) THERAPEUTIC, IN PATIENTS WITH ACUTE INTERMITTENT PORPHYRIA 2018 In: JOURNAL OF GENERAL INTERNAL MEDICINE. - 0884-8734. ; 33, s. S287-S288 Conference paper (other academic/artistic)
34.	Sardh, E, et al. (author) A phase 1/2, randomized, placebo controlled and open label extension studies of Givosiran and investigational RNA interference therapeutic, in patients with acute intermittent porphyria 2018 In: JOURNAL OF HEPATOLOGY. - 0168-8278. ; 68, s. S66-S67 Conference paper (other academic/artistic)
35.	Sardh, E, et al. (author) Phase 1, Randomized, Placebo Controlled Study of Givosiran, an Investigational RNA Interference (RNAi) Therapeutic, in Patients with Acute Intermittent Porphyria: Interim study results 2017 In: HEPATOLOGY. - 0270-9139. ; 66, s. 427A-427A Conference paper (other academic/artistic)
36.	Shang, Z. Y., et al. (author) Weakened growth of cropland-N2O emissions in China associated with nationwide policy interventions 2019 In: Global Change Biology. - : Wiley. - 1354-1013 .- 1365-2486. ; 25:11, s. 3706-3719 Journal article (peer-reviewed)abstract China has experienced rapid agricultural development over recent decades, accompanied by increased fertilizer consumption in croplands; yet, the trend and drivers of the associated nitrous oxide (N2O) emissions remain uncertain. The primary sources of this uncertainty are the coarse spatial variation of activity data and the incomplete model representation of N2O emissions in response to agricultural management. Here, we provide new data-driven estimates of cropland-N2O emissions across China in 1990-2014, compiled using a global cropland-N2O flux observation dataset, nationwide survey-based reconstruction of N-fertilization and irrigation, and an updated nonlinear model. In addition, we have evaluated the drivers behind changing cropland-N2O patterns using an index decomposition analysis approach. We find that China's annual cropland-N2O emissions increased on average by 11.2 Gg N/year(2) (p < .001) from 1990 to 2003, after which emissions plateaued until 2014 (2.8 Gg N/year(2), p = .02), consistent with the output from an ensemble of process-based terrestrial biosphere models. The slowdown of the increase in cropland-N2O emissions after 2003 was pervasive across two thirds of China's sowing areas. This change was mainly driven by the nationwide reduction in N-fertilizer applied per area, partially due to the prevalence of nationwide technological adoptions. This reduction has almost offset the N2O emissions induced by policy-driven expansion of sowing areas, particularly in the Northeast Plain and the lower Yangtze River Basin. Our results underline the importance of high-resolution activity data and adoption of nonlinear model of N2O emission for capturing cropland-N2O emission changes. Improving the representation of policy interventions is also recommended for future projections.
37.	Wong, L, et al. (author) GENETIC EVIDENCE OF EOSINOPHIL NUMBER UNDERPINNING PR3-AAV AND PLAUSIBLE HOST GENETIC PREDISPOSITION TO MICROBIAL DRIVERS OF DISEASE 2019 In: RHEUMATOLOGY. - 1462-0324. ; 58, s. 80-81 Conference paper (other academic/artistic)
38.	Jones, Robert P., et al. (author) Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma : A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial 2019 In: JAMA Surgery. - : AMER MEDICAL ASSOC. - 2168-6254 .- 2168-6262. ; 154:11, s. 1038-1048 Journal article (peer-reviewed)abstract Importance: The patterns of disease recurrence after resection of pancreatic ductal adenocarcinoma with adjuvant chemotherapy remain unclear.Objective: To define patterns of recurrence after adjuvant chemotherapy and the association with survival.Design, Setting, and Participants: Prospectively collected data from the phase 3 European Study Group for Pancreatic Cancer 4 adjuvant clinical trial, an international multicenter study. The study included 730 patients who had resection and adjuvant chemotherapy for pancreatic cancer. Data were analyzed between July 2017 and May 2019.Interventions: Randomization to adjuvant gemcitabine or gemcitabine plus capecitabine.Main Outcomes and Measures: Overall survival, recurrence, and sites of recurrence.Results: Of the 730 patients, median age was 65 years (range 37-81 years), 414 were men (57%), and 316 were women (43%). The median follow-up time from randomization was 43.2 months (95% CI, 39.7-45.5 months), with overall survival from time of surgery of 27.9 months (95% CI, 24.8-29.9 months) with gemcitabine and 30.2 months (95% CI, 25.8-33.5 months) with the combination (HR, 0.81; 95% CI, 0.68-0.98; P=.03). The 5-year survival estimates were 17.1% (95% CI, 11.6%-23.5%) and 28.0% (22.0%-34.3%), respectively. Recurrence occurred in 479 patients (65.6%); another 78 patients (10.7%) died without recurrence. Local recurrence occurred at a median of 11.63 months (95% CI, 10.05-12.19 months), significantly different from those with distant recurrence with a median of 9.49 months (95% CI, 8.44-10.71 months) (HR, 1.21; 95% CI, 1.01-1.45; P=.04). Following recurrence, the median survival was 9.36 months (95% CI, 8.08-10.48 months) for local recurrence and 8.94 months (95% CI, 7.82-11.17 months) with distant recurrence (HR, 0.89; 95% CI, 0.73-1.09; P=.27). The median overall survival of patients with distant-only recurrence (23.03 months; 95% CI, 19.55-25.85 months) or local with distant recurrence (23.82 months; 95% CI, 17.48-28.32 months) was not significantly different from those with only local recurrence (24.83 months; 95% CI, 22.96-27.63 months) (P=.85 and P=.35, respectively). Gemcitabine plus capecitabine had a 21% reduction of death following recurrence compared with monotherapy (HR, 0.79; 95% CI, 0.64-0.98; P=.03).Conclusions and Relevance: There were no significant differences between the time to recurrence and subsequent and overall survival between local and distant recurrence. Pancreatic cancer behaves as a systemic disease requiring effective systemic therapy after resection.Trial Registration: ClinicalTrials.gov identifier: NCT00058201, EudraCT 2007-004299-38, and ISRCTN 96397434. This secondary analysis of a randomized clinical trial investigates patterns of recurrence after adjuvant chemotherapy in pancreatic cancer and the association with survival.
39.	Viti, M., et al. (author) Spatial resolution studies for the PERCIVAL sensor 2015 In: Journal of Instrumentation. - 1748-0221. ; 10 Journal article (peer-reviewed)abstract The PERCIVAL ("Pixelated Energy Resolving CMOS Imager, Versatile and Large") is a collaboration of DESY, RAL/STFC, ELETTRA, and DLS to develop a monolithic active pixel sensor (MAPS) to provide a suitable detector for photon science for the photon energy regime between 250 eV and 1 keV. An important performance parameter is the spatial resolution which can be inferred from the Modulation Transfer Function (MTF). The MTF measures in optical systems the relative contrast of a pattern in function of the spatial frequency. With a back-thinned and back- illuminated PERCIVAL prototype chip, dedicated MTF evaluation data were taken at Elettra's TwinMic Beamline in March 2014 at a photon energy of 535 eV. We will present our MTF derivation approaches together with MTF results for 3 pixel types of the irradiated test sensor.
40.	Wunderer, C. B., et al. (author) The PERCIVAL soft X-ray imager 2015 In: Journal of Instrumentation. - 1748-0221. ; 10:2 Journal article (peer-reviewed)abstract With the increased brilliance of state-of-the-art Synchrotron radiation sources and the advent of Free Electron Lasers enabling revolutionary science on atomic length and time scales with EUV to X-ray photons comes an urgent need for suitable photon imaging detectors. Requirements include high frame rates, very large dynamic range, single-photon counting capability with low probability of false positives, and (multi)-megapixels. PERCIVAL ("Pixelated Energy Resolving CMOS Imager, Versatile And Large") is currently being developed by a collaboration of DESY, RAL, Elettra, DLS and Pohang to address this need for the soft X-ray regime. PERCIVAL is a monolithic active pixel sensor (MAPS), i.e. based on CMOS technology. It will be back-thinned to access its primary energy range of 250 eV to 1 keV with target efficiencies above 90%. According to its preliminary specifications, the roughly 10 × 10 cm2, 3.5k × 3.7k monolithic "PERCIVAL13M" sensor will operate at frame rates up to 120 Hz (commensurate with most FELs) and use multiple gains within its 27 μm pixels to measure 1 to ∼ 105 (500 eV) simultaneously-arriving photons. A smaller "PERCIVAL2M" with ∼ 1.4k × 1.5k pixels is also planned. Currently, small-scale back-illuminated prototype systems (160 × 210 pixels of 25 μm pitch) are undergoing detailed testing with X-rays and optical photons. In March 2014, a prototype sensor was tested at 350 eV-2 keV at Elettra's TwinMic beamline. The data recorded include diffraction patterns at 350 eV and 400 eV, knife edge and sub-pixel pinhole illuminations, and comparisons of different pixel types. Another prototype chip will be submitted in fall 2014, first larger sensors could be in hand in late 2015.
41.	Green, B. L., et al. (author) All-optical hyperpolarization of electron and nuclear spins in diamond 2017 In: Physical Review B. - College Park : American Physical Society. - 2469-9950 .- 2469-9969. ; 96:5 Journal article (peer-reviewed)abstract Low thermal polarization of nuclear spins is a primary sensitivity limitation for nuclear magnetic resonance. Here we demonstrate optically pumped (microwave-free) nuclear spin polarization of C-13 and N-15 in N-15-doped diamond. (15)Npolarization enhancements up to- 2000 above thermal equilibrium are observed in the paramagnetic system Ns(0). Nuclear spin polarization is shown to diffuse to bulk C-13 with NMR enhancements of -200 at room temperature and -500 at 240 K, enabling a route to microwave-free high-sensitivity NMR study of biological samples in ambient conditions.
42.	Ivesono, Timothy, et al. (author) 3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer : 3-year follow-up of the SCOT non-inferiority RCT 2019 In: Health Technology Assessment. - : NIHR JOURNALS LIBRARY. - 1366-5278 .- 2046-4924. ; 23:64, s. 1-88 Journal article (peer-reviewed)abstract Background: Oxaliplatin and fluoropyrimidine chemotherapy administered over 6 months is the standard adjuvant regimen for patients with high-risk stage II or III colorectal cancer. However, the regimen is associated with cumulative toxicity, characterised by chronic and often irreversible neuropathy.Objective: To assess the efficacy of 3-month versus 6-month adjuvant chemotherapy for colorectal cancer and to compare the toxicity, health-related quality of life and cost-effectiveness of the durations.Design: An international, randomised, open-label, non-inferiority, Phase III, parallel-group trial.Setting: A total of 244 oncology clinics from six countries: UK (England, Scotland, Wales and Northern Ireland), Denmark, Spain, Sweden, Australia and New Zealand.Participants: Adults aged >= 18 years who had undergone curative resection for high-risk stage II or III adenocarcinoma of the colon or rectum.Interventions: The adjuvant treatment regimen was either oxaliplatin and 5-fluorouracil or oxaliplatin and capecitabine, randomised to be administered over 3 or 6 months.Main outcomes measures: The primary outcome was disease-free survival. Overall survival, adverse events, neuropathy and health-related quality of life were also assessed. The main cost categories were chemotherapy treatment and hospitalisation. Cost-effectiveness was assessed through incremental cost comparisons and quality-adjusted life-year gains between the options and was reported as net monetary benefit using a willingness-to-pay threshold of 30,000 pound per quality-adjusted life-year per patient.Result: Recruitment is closed. In total, 6088 patients were randomised (3044 per group) between 27 March 2008 and 29 November 2013, with 6065 included in the intention-to-treat analyses (3-month analysis, n = 3035; 6-month analysis, n = 3030). Follow-up for the primary analysis is complete. The 3-year disease-free survival rate in the 3-month treatment group was 76.7% (standard error 0.8%) and in the 6-month treatment group was 77.1% (standard error 0.8%), equating to a hazard ratio of 1.006 (95% confidence interval 0.909 to 1.114; p-value for non-inferiority = 0.012), confirming non-inferiority for 3-month adjuvant chemotherapy. Frequent adverse events (alopecia, anaemia, anorexia, diarrhoea, fatigue, hand-foot syndrome, mucositis, sensory neuropathy, neutropenia, pain, rash, altered taste, thrombocytopenia and watery eye) showed a significant increase in grade with 6-month duration; the greatest difference was for sensory neuropathy (grade >= 3 was 4% for 3-month vs.16% for 6-month duration), for which a higher rate of neuropathy was seen for the 6-month treatment group from month 4 to >= 5 years (p < 0.001). Quality-of-life scores were better in the 3-month treatment group over months 4-6. A cost-effectiveness analysis showed 3-month treatment to cost 4881 pound less over the 8-year analysis period, with an incremental net monetary benefit of 7246 pound per patient.Conclusions: The study achieved its primary end point, showing that 3-month oxaliplatin-containing adjuvant chemotherapy is non-inferior to 6 months of the same regimen; 3-month treatment showed a better safety profile and cost less. For future work, further follow-up will refine long-term estimates of the duration effect on disease-free survival and overall survival. The health economic analysis will be updated to include long-term extrapolation for subgroups. We expect these analyses to be available in 2019-20. The Short Course Oncology Therapy (SCOT) study translational samples may allow the identification of patients who would benefit from longer treatment based on the molecular characteristics of their disease.
43.	Kim, Joo-Hong, et al. (author) Salinity Control of Thermal Evolution of Late Summer Melt Ponds on Arctic Sea Ice 2018 In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 45:16, s. 8304-8313 Journal article (peer-reviewed)abstract The thermal evolution of melt ponds on Arctic sea ice was investigated through a combination of autonomous observations and two-dimensional high-resolution fluid dynamics simulations. We observed one relatively fresh pond and one saline pond on the same ice floe, with similar depth. The comparison of observations and simulations indicates that thermal convection dominates in relatively fresh ponds, but conductive heat transfer dominates in salt-stratified ponds. Using a parameterized surface energy balance, we estimate that the heat flux to the ice is larger under the saline pond than the freshwater pond when averaged over the observational period. The deviation is sensitive to assumed wind, varying between 3 and 14 W/m(2) for winds from 0 to 5 m/s. If this effect persists as conditions evolve through the melt season, our results suggest that this imbalance potentially has a climatologically significant impact on sea-ice evolution. Plain Language Summary Sea ice provides key feedbacks on polar and global climate, with melt ponds being particularly significant. Melt ponds darken the ice surface, thereby increasing the absorption of sunlight and accelerating ice melt. This study provides a new perspective on melt-pond salinity, its previously unrecognized significance in controlling the thermal properties of ponds, and the potential impact on ice melting as we transition toward a younger sea ice cover. Many state-of-the-art sea ice models represent melt ponds as a freshwater layer with a surface temperature of 0 degrees C, consistent with a past Arctic ocean dominated by desalinated perennial ice and relatively fresh ponds. However, perennial ice has diminished in recent decades, with increasing prevalence of young saline ice. This leads to ponds with a wider range of salinities and temperatures. We show that salinity strongly impacts pond temperatures, using observations of adjacent freshwater and saline melt ponds on Arctic sea ice. Combining this data with model simulations, we find that melt-pond salinity impacts heat transfer to the ice below and the resulting melting rate. Our study reveals that melt-pond salinity and salt stratification are key variables influencing heat transfer in melt ponds, which need to be considered in future model development.
44.	Legge, SE, et al. (author) Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia 2017 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 22:10, s. 1509-1509 Journal article (other academic/artistic)abstract Correction to: Molecular Psychiatry advance online publication, 12 July 2016; doi:10.1038/mp.2016.97 The ninth author’s name was presented incorrectly. It should have been listed as LF Jarskog.
45.	Legge, SE, et al. (author) Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia 2018 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 23:1, s. 162-163 Journal article (peer-reviewed)abstract Correction to: Molecular Psychiatry (2017) 22: 1502-1508; advance online publication, 12 July 2017; doi: 10.1038/mp.2016.97 In the first paragraph of the Results section and Figure 1, the authors incorrectly referred to the finding of SNP rs77897117. The correct SNP is rs77897177. The corrected figure appears in previous page.
46.	Oberlick, EM, et al. (author) Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors 2019 In: Cell reports. - : Elsevier BV. - 2211-1247. ; 28:9, s. 2331- Journal article (peer-reviewed)
47.	Rees, MG, et al. (author) Correlating chemical sensitivity and basal gene expression reveals mechanism of action 2016 In: Nature chemical biology. - : Springer Science and Business Media LLC. - 1552-4469 .- 1552-4450. ; 12:2, s. 109- Journal article (peer-reviewed)
48.	Robles-Zurita, Jose, et al. (author) SCOT : a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer 2018 In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 119:11, s. 1332-1338 Journal article (peer-reviewed)abstract BACKGROUND: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.METHODS: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Quality-adjusted partitioned survival analysis and Kaplan-Meier Sample Average Estimator estimated QALYs and costs. Probabilistic sensitivity and subgroup analysis was undertaken.RESULTS: The 3M arm is less costly (-4881; pound 95% CI: -6269; pound -3492) pound and entails (non-significant) QALY gains (0.08; 95% CI: -0.086; 0.230) due to a better significant quality of life. The net monetary benefit was significantly higher in 3M under a wide range of monetary values of a QALY. The subgroup analysis found similar results for patients in the CAPOX regimen. However, for the FOLFOX regimen, 3M had lower QALYs than 6M (not statistically significant).CONCLUSIONS: Overall, 3M dominates 6M with no significant detrimental impact on QALYs. The results provide the economic case that a 3M treatment strategy should be considered a new standard of care.
49.	Singh, T, et al. (author) The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:8, s. 1167- Journal article (peer-reviewed)

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