| 1. |
- Wild, W., et al.
(author)
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Millimetron—a large Russian-European submillimeter space observatory
- 2009
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In: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:1, s. 221-244
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Journal article (peer-reviewed)abstract
- Millimetron is a Russian-led 12 m diameter submillimeter and far-infrared space observatory which is included in the Space Plan of the Russian Federation for launch around 2017. With its large collecting area and state-of-the-art receivers, it will enable unique science and allow at least one order of magnitude improvement with respect to the Herschel Space Observatory. Millimetron will be operated in two basic observing modes: as a single-dish observatory, and as an element of a ground-space very long baseline interferometry (VLBI) system. As single-dish, angular resolutions on the order of 3 to 12 arc sec will be achieved and spectral resolutions of up to a million employing heterodyne techniques. As VLBI antenna, the chosen elliptical orbit will provide extremely large VLBI baselines (beyond 300,000 km) resulting in micro-arc second angular resolution.
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| 2. |
- Cockell, C.S., et al.
(author)
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Darwin - an experimental astronomy mission to search for extrasolar planets
- 2009
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In: Experimental Astronomy. - 0922-6435 .- 1572-9508. ; 23:1, s. 435-461
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Journal article (peer-reviewed)abstract
- As a response to ESA call for mission concepts for its Cosmic Vision 2015–2025 plan, we propose a mission called Darwin. Its primary goal is the study of terrestrial extrasolar planets and the search for life on them. In this paper, we describe different characteristics of the instrument.
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| 3. |
- Krebs, Frederik C, et al.
(author)
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A round robin study of flexible large-area roll-to-roll processed polymer solar cell modules
- 2009
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In: SOLAR ENERGY MATERIALS AND SOLAR CELLS. - : Elsevier BV. - 0927-0248. ; 93:11, s. 1968-1977
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Journal article (peer-reviewed)abstract
- A round robin for the performance of roll-to-roll coated flexible large-area polymer solar-cell modules involving 18 different laboratories in Northern America, Europe and Middle East is presented. The study involved the performance measurement of the devices at one location (Riso DTU) followed by transportation to a participating laboratory for performance measurement and return to the starting location (Riso DTU) for re-measurement of the performance. It was found possible to package polymer solar-cell modules using a flexible plastic barrier material in such a manner that degradation of the devices played a relatively small role in the experiment that has taken place over 4 months. The method of transportation followed both air-mail and surface-mail paths.
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| 4. |
- Mathijssen, Simon G. J., et al.
(author)
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Monolayer coverage and channel length set the mobility in self-assembled monolayer field-effect transistors
- 2009
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In: Nature Nanotechnology. - : Nature Publishing Group. - 1748-3387 .- 1748-3395. ; 4:10, s. 674-680
-
Journal article (peer-reviewed)abstract
- The mobility of self-assembled monolayer field-effect transistors (SAMFETs) traditionally decreases dramatically with increasing channel length. Recently, however, SAMFETs using liquid-crystalline molecules have been shown to have bulk-like mobilities that are virtually independent of channel length. Here, we reconcile these scaling relations by showing that the mobility in liquid crystalline SAMFETs depends exponentially on the channel length only when the monalayer is incomplete. We explain this dependence both numerically and analytically, and show that charge transport is not affected by carrier injection, grain boundaries or conducting island size. At partial coverage, that is when the monolayer is incomplete, liquid-crystalline SAMFETs thus form a unique model system to study size-dependent conductance originating from charge percolation in two dimensions.
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| 5. |
- Post, Eric, et al.
(author)
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Ecological Dynamics Across the Arctic Associated with Recent Climate Change
- 2009
-
In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 325:5946, s. 1355-1358
-
Research review (peer-reviewed)abstract
- At the close of the Fourth International Polar Year, we take stock of the ecological consequences of recent climate change in the Arctic, focusing on effects at population, community, and ecosystem scales. Despite the buffering effect of landscape heterogeneity, Arctic ecosystems and the trophic relationships that structure them have been severely perturbed. These rapid changes may be a bellwether of changes to come at lower latitudes and have the potential to affect ecosystem services related to natural resources, food production, climate regulation, and cultural integrity. We highlight areas of ecological research that deserve priority as the Arctic continues to warm.
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| 6. |
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| 7. |
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| 8. |
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| 9. |
- Mantovani Nardes, Alexandre, et al.
(author)
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Microscopic understanding of the anisotropic conductivity of PEDOT : PSS thin films
- 2007
-
In: Advanced Materials. - : Wiley-VCH Verlag. - 0935-9648 .- 1521-4095. ; 19:9, s. 1196-
-
Journal article (peer-reviewed)abstract
- The amsotropic conductivity of thin films of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is correlated to the film morphology as obtained from scanning tunneling and atomic force microscopy images. The material was found to consist of layers of flattened PEDOT-rich particles that are separated by quasi-continuous PSS lamella (see figure).
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| 10. |
- Mathijssen, Simon G. J., et al.
(author)
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Charge trapping at the dielectric of organic transistors visualized in real time and space
- 2008
-
In: Advanced Materials. - : Wiley-VCH Verlag. - 0935-9648 .- 1521-4095. ; 20:5, s. 975-
-
Journal article (peer-reviewed)abstract
- Scanning Kelvin probe microscopy demonstrates that water-induced charge trapping at the SiO2 dielectric visualized in real time and space - is responsible for the commonly observed gate-bias-induced threshold-voltage shift in organic field-effect transistors. When a bias is applied to the electrodes, charges are injected onto the SiO2 (see background of the figure). When the contacts are grounded, the charges are released again (foreground picture).
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| 11. |
- Mathijssen, Simon G. J., et al.
(author)
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Manipulating the local light emission in organic light-emitting diodes by using patterned self-assembled monolayers
- 2008
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In: Advanced Materials. - : Wiley-VCH Verlag. - 0935-9648 .- 1521-4095. ; 20:14, s. 2703-
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Journal article (peer-reviewed)abstract
- Patterned organic light-emitting diodes are fabricated by using microcontactDrinted self-assembled monolayers on a gold anode (see background figure). Molecules with dipole moments in opposite directions result in an increase or a decrease of the local work function (foreground picture), providing a direct handle on charge injection and enabling local modification of the light emission
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| 12. |
- Stuhr-Hansen, Nicolai, et al.
(author)
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Organoselenium-Substituted Poly(p-phenylenevinylene)
- 2005
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In: Heteroatom Chemistry. - : Wiley. - 1042-7163 .- 1098-1071. ; 16:7, s. 656-662
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Journal article (peer-reviewed)abstract
- A new type of conjugated polymer, organoselenium substituted poly(p-pheylenevinylene) (PPV), was synthesized from the corresponding alkylselenenyl p-xylylene dibromide via a Gilch route using potassium tert-butoxide in THF. The p-xylylene dibromide precursors were synthesized by reacting lithiated bis(methoxymethyl)benzenes with elemental selenium, followed by alkylation of the generated selenolates. As a final demasking step, the bromomethyl functions were liberated by ether cleavage using boron tribromide. Bis-alkylselenenyl PPV was obtained with an average molecular weight Mw of approximately 300,000 g/mol and with polydispersity Mw/Mn=2. Due to low solubility, monoalkylselenenyl PPV was obtained with a considerably lower average molecular weight in the proximity of 16,000 g/mol and with a polydispersity slightly larger than 3. Absorption and flourescence spectroscopy revealed that the bis-alkylselenenyl PPV is extensively conjugated.
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| 13. |
- Bjerkeli, Per, 1977, et al.
(author)
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Odin observations of water in molecular outflows and shocks
- 2009
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 507:3, s. 1455-1466
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Journal article (peer-reviewed)abstract
- Aims: We investigate the ortho-water abundance in outflows and shocks in order to improve our knowledge of shock chemistry and of the physics behind molecular outflows.Methods: We used the Odin space observatory to observe the H2O(110-101) line. We obtain strip maps and single pointings of 13 outflows and two supernova remnants where we report detections for eight sources. We used RADEX to compute the beam averaged abundances of o-H2O relative to H2. In the case of non-detection, we derive upper limits on the abundance.Results: Observations of CO emission from the literature show that the volume density of H2 can vary to a large extent, a parameter that puts severe uncertainties on the derived abundances. Our analysis shows a wide range of abundances reflecting the degree to which shock chemistry affects the formation and destruction of water. We also compare our results with recent results from the SWAS team.Conclusions: Elevated abundances of ortho-water are found in several sources. The abundance reaches values as high as what would be expected from a theoretical C-type shock where all oxygen, not in the form of CO, is converted to water. However, the high abundances we derive could also be due to the low densities (derived from CO observations) that we assume. The water emission may in reality stem from high density regions much smaller than the Odin beam. We do not find any relationship between the abundance and the mass loss rate. On the other hand, there is a relation between the derived water abundance and the observed maximum outflow velocity.Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes) and Centre National d'Étude Spatiale (CNES).The Swedish ESO Submillimetre Telescope (SEST) located at La Silla, Chile was funded by the Swedish Research Council (VR) and the European Southern Observatory. It was decommissioned in 2003. Appendix B is only available in electronic form at http://www.aanda.org
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| 14. |
- Boon, Hanneke, 1981-, et al.
(author)
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Substrate Source Use in Older, Trained Males after Decades of Endurance Training
- 2007
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In: Medicine & Science in Sports & Exercise. - Philadelphia, PA : Lippincott Williams & Wilkins. - 0195-9131 .- 1530-0315. ; 39:12, s. 2160-2170
-
Journal article (peer-reviewed)abstract
- PURPOSE: The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls. METHODS: [U-C]palmitate and [6,6-H2]glucose tracers were applied to assess plasma free fatty acid (FFA) and glucose oxidation rates, and to estimate muscle- and/or lipoprotein-derived triacylglycerol (TG) and muscle glycogen use. Subjects were 10 long-term exercising, endurance-trained males and 10 sedentary controls (age 57 +/- 1 and 60 +/- 2 yr, respectively). Muscle biopsy samples were collected before and after exercise to assess muscle fiber type-specific intramyocellular lipid and glycogen content. RESULTS: During exercise, plasma palmitate Ra, Rd, and Rox were significantly greater in the trained subjects compared with the controls (Ra: 0.36 +/- 0.02 and 0.25 +/- 0.02; Rd: 0.36 +/- 0.03 and 0.24 +/- 0.02; Rox: 0.31 +/- 0.02 and 0.20 +/- 0.02 mmol.min, respectively, P < 0.01). This resulted in greater plasma FFA and total fat oxidation rates in the trained versus sedentary subjects (P < 0.001). Muscle- and/or lipoprotein-derived TG use contributed 10 +/- 2 and 11 +/- 3% in the trained and control groups, respectively (NS). No significant net changes in muscle fiber lipid content were observed. CONCLUSIONS: Older, endurance-trained males oxidize more fat during moderate-intensity exercise than do sedentary controls. This greater total fat oxidation rate is attributed to a higher plasma FFA release, uptake, and oxidation rate. In contrast, intramyocellular triacylglycerol does not seem to represent a major substrate source during 1 h of moderate-intensity exercise in older trained or sedentary men. ©2007 The American College of Sports Medicine.
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| 15. |
- Cain, William S., et al.
(author)
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Independence of odor Quality and Absolute Sensitivity in a Study of Aging
- 2008
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In: Chemosensory Perception. - : Springer. - 1936-5802 .- 1936-5810. ; 1, s. 24-33
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Journal article (peer-reviewed)abstract
- Young, middle-aged, and senior subjects performed tasks designed to examine whether odor quality discrimination varies independently of sensitivity. One task entailed detection of 2-heptanone and the others AB-X discrimination of quality for sets of 2-heptanone and homologues or 2-heptanone and non-ketones. Subjects sought to discriminate either at intensity-matched concentrations far above threshold, but fixed across subjects, or at levels adjusted to neutralize differences in sensitivity. The young and middle-aged groups manifested the same absolute sensitivity, but the senior group poorer sensitivity. Performance in quality discrimination, however, declined progressively. Performance lacked an association with absolute sensitivity, no matter how examined. These data, in conjunction with converging findings from patients with neurological damage, studies of brain imaging, and the relation between concentration and quality discrimination in younger persons, suggest largely independent processing of odor quality and intensity.
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| 16. |
- Charrier, Dimitri S. H., et al.
(author)
-
Real versus measured surface potentials in scanning Kelvin probe microscopy
- 2008
-
In: ACS Nano. - : American Chemical Society. - 1936-0851 .- 1936-086X. ; 2:4, s. 622-626
-
Journal article (peer-reviewed)abstract
- Noncontact potentiometry or scanning Kelvin probe microscopy (SKPM) is a widely used technique to study charge injection and transport in (in)organic devices by measuring a laterally resolved local potential. This technique suffers from the significant drawback that experimentally obtained curves do not generally reflect the true potential profile in the device due to nonlocal coupling between the probing tip and the device. In this work, we quantitatively explain the experimental SKPM response and by doing so directly link theoretical device models to real observables. In particular, the model quantitatively explains the effects of the tip-sample distance and the dependence on the orientation of the probing tip with respect to the device.
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| 17. |
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| 18. |
- Goldhahn, Jörg, et al.
(author)
-
Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis
- 2008
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In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 43:2, s. 343-347
-
Journal article (peer-reviewed)abstract
- Pre-clinical studies indicate that pharmacologic agents can augment fracture union. If these pharmacologic approaches could be translated into clinical benefit and offered to patients with osteoporosis or patients with other risks for impaired fracture union (e.g. in subjects with large defects or open fractures with high complication rate), they could provide an important adjunct to the treatment of fractures. However, widely accepted guidelines are important to encourage the conduct of studies to evaluate bioactive substances, drugs, and new agents that may promote fracture union and subsequent return to normal function. A consensus process was initiated to provide recommendations for the clinical evaluation of potential therapies to augment fracture repair in patients with meta- and diaphyseal fractures. Based on the characteristics of fracture healing and fixation, the following study objectives of a clinical study may be appropriate: a) acceleration of fracture union, b) acceleration of return to normal function and c) reduction of fracture healing complications. The intended goal(s) should determine subsequent study methodology. While an acceleration of return to normal function or a reduction of fracture healing complications in and of themselves may be sufficient primary study endpoints for a phase 3 pivotal study, acceleration of fracture union alone is not. Radiographic evaluation may either occur at multiple time points during the healing process with the aim of measuring the time taken to reach a defined status (e.g. cortical bridging of three cortices or disappearance of fracture lines), or could be obtained at a single pre-determined timepoint, were patients are expected to reach a common clinical milestone (i.e. pain free full weight-bearing in weight-bearing fracture cases). Validated Patient Reported Outcomes (PRO's) measures will need to support the return to normal function co-primary endpoints. If reduction of complication rate (e.g. non-union) is the primary objective, the anticipated complications must be defined in the study protocol, along with their possible associations with the specified fracture type and fixation device. The study design should be randomized, parallel, double-blind, and placebo-controlled, and all fracture subjects should receive a standardized method of fracture fixation, defined as Standard of Care. © 2008 Elsevier Inc. All rights reserved.
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| 19. |
- Goldhahn, Jörg, et al.
(author)
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Critical issues in translational and clinical research for the study of new technologies to enhance bone repair
- 2008
-
In: Journal of Bone and Joint Surgery. American volume. - : Journal of Bone and Joint Surgery. - 0021-9355 .- 1535-1386. ; 90:Supplement 1, s. 43-47
-
Journal article (peer-reviewed)abstract
- Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements.
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| 20. |
- Graham, Nicholas A. J., et al.
(author)
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Climate Warming, Marine Protected Areas and the Ocean-Scale Integrity of Coral Reef Ecosystems
- 2008
-
In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 3:8, s. e3039-
-
Journal article (peer-reviewed)abstract
- Coral reefs have emerged as one of the ecosystems most vulnerable to climate variation and change. While the contribution of a warming climate to the loss of live coral cover has been well documented across large spatial and temporal scales, the associated effects on fish have not. Here, we respond to recent and repeated calls to assess the importance of local management in conserving coral reefs in the context of global climate change. Such information is important, as coral reef fish assemblages are the most species dense vertebrate communities on earth, contributing critical ecosystem functions and providing crucial ecosystem services to human societies in tropical countries. Our assessment of the impacts of the 1998 mass bleaching event on coral cover, reef structural complexity, and reef associated fishes spans 7 countries, 66 sites and 26 degrees of latitude in the Indian Ocean. Using Bayesian meta-analysis we show that changes in the size structure, diversity and trophic composition of the reef fish community have followed coral declines. Although the ocean scale integrity of these coral reef ecosystems has been lost, it is positive to see the effects are spatially variable at multiple scales, with impacts and vulnerability affected by geography but not management regime. Existing no-take marine protected areas still support high biomass of fish, however they had no positive affect on the ecosystem response to large-scale disturbance. This suggests a need for future conservation and management efforts to identify and protect regional refugia, which should be integrated into existing management frameworks and combined with policies to improve system-wide resilience to climate variation and change.
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| 21. |
- Lakhwani, Girish, et al.
(author)
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Intensive Chiroptical Properties of Chiral Polyfluorenes Associated with Fibril Formation
- 2009
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In: Journal of Physical Chemistry B. - : American Chemical Society. - 1520-6106 .- 1520-5207. ; 113:43, s. 14047-14051
-
Journal article (peer-reviewed)abstract
- Thin films of chiral poly {9,9-bis[(3S)-3,7-dimethyloctyl]-2,7-fluorene} (1) were studied using circular dichroism (CD) spectroscopy. Films spin coated from chloroform solution, show CD with a degree of polarization g(abs) (= +4 x 10(-4) at 400 nm) that is independent of film thickness (50-290 nm). This implies that gabs is an intensive property of the material and related to the chiral organization of the molecules on a length scale less than 50 nm. Atomic force microscopy (AFM) on the films reveals fibrils. Addition of nonsolvent methanol to a solution of 1 in chloroform leads to fibril formation in solution and results in CD similar in band shape to that of the pristine spin coated films from chloroform solution and a g(abs) comparable in magnitude. Thus the chiral molecular arrangement leading to circular dichroism is part of the internal structure of these fibrils.
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| 22. |
- Liseau, Rene, et al.
(author)
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O18O and C18O observations of rho Oph A
- 2009
-
Journal article (other academic/artistic)abstract
- Observations of the (N_J=1_1-1_0) ground state transition of O_2 with the Odin satellite resulted in a about 5 sigma detection toward the dense core rho Oph A. At the frequency of the line, 119 GHz, the Odin telescope has a beam width of 10', larger than the size of the dense core, so that the precise nature of the emitting source and its exact location and extent are unknown. The current investigation is intended to remedy this. Telluric absorption makes ground based O_2 observations essentially impossible and observations had to be done from space. mm-wave telescopes on space platforms were necessarily small, which resulted in large, several arcminutes wide, beam patterns. Although the Earth's atmosphere is entirely opaque to low-lying O_2 transitions, it allows ground based observations of the much rarer O18O in favourable conditions and at much higher angular resolution with larger telescopes. In addition, rho Oph A exhibits both multiple radial velocity systems and considerable velocity gradients. Extensive mapping of the region in the proxy C18O (J=3-2) line can be expected to help identify the O_2 source on the basis of its line shape and Doppler velocity. Line opacities were determined from observations of optically thin 13C18O (J=3-2) at selected positions. During several observing periods, two C18O intensity maxima in rho Oph A were searched for in the 16O18O (2_1-0_1) line at 234 GHz with the 12m APEX telescope. Our observations resulted in an upper limit on the integrated O18O intensity of < 0.01 K km/s (3 sigma) into the 26.5" beam. We conclude that the source of observed O_2 emission is most likely confined to the central regions of the rho Oph A cloud. In this limited area, implied O_2 abundances could thus be higher than previously reported, by up to two orders of magnitude.
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| 23. |
- Liseau, René, 1949, et al.
(author)
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q1 Eridani: a solar-type star with a planet and a dust belt
- 2008
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In: Astronomy & Astrophysics. ; 480, s. L47-L50
-
Journal article (peer-reviewed)abstract
- Context: Far-infrared excess emission from main-sequence stars is due to dust produced by orbiting minor bodies. In these disks, larger bodies, such as planets, may also be present and the understanding of their incidence and influence currently presents a challenge. Aims: Only very few solar-type stars exhibiting an infrared excess and harbouring planets are known to date. Indeed, merely a single case of a star-planet-disk system has previously been detected at submillimeter (submm) wavelengths. Consequently, one of our aims is to understand the reasons for these poor statistics, i.e., whether these results reflected the composition and/or the physics of the planetary disks or were simply due to observational bias and selection effects. Finding more examples would be very significant. Methods: The selected target, q1 Eri, is a solar-type star, which was known to possess a planet, q1 Eri b, and to exhibit excess emission at IRAS wavelengths, but had remained undetected in the millimeter regime. Therefore, submm flux densities would be needed to better constrain the physical characteristics of the planetary disk. Consequently, we performed submm imaging observations of q1 Eri. Results: The detected dust toward q1 Eri at 870 μm exhibits the remarkable fact that the entire SED, from the IR to mm-wavelengths, is fit by a single-temperature blackbody function (60 K). This would imply that the emitting regions are confined to a narrow region (ring) at radial distances much larger than the orbital distance of q1 Eri b, and that the emitting particles are considerably larger than some hundred micron. However, the 870 μm source is extended, with a full-width-half-maximum of roughly 600 AU. Therefore, a physically more compelling model also invokes a belt of cold dust (17 K), located at 300 AU from the star and about 60 AU wide. Conclusions: The minimum mass of 0.04 M⊕ (3 M_Moon) of 1 mm-size icy ring-particles is considerable, given the stellar age of ⪆ 1 Gyr. These big grains form an inner edge at about 25 AU, which may suggest the presence of an unseen outer planet (q1 Eri c).Based on observations with APEX, Llano Chajnantor, Chile.
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| 24. |
- Majdalawieh, Osama F, et al.
(author)
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Linearity and Lever Ratio of the Normal and Reconstructed Cadaveric Human Middle Ear
- 2008
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In: Otology & Neurotology. - 1531-7129. ; 29:6, s. 796-802
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Journal article (peer-reviewed)abstract
- Hypothesis: The linearity and the level ratio are different in reconstructed ears. Background: The linearity of the reconstructed human middle ear (ME) has not been previously explored. It is important to analyze if high sound pressure levels (SPLs) result in distortion due to nonlinearities particularly because hearing aids have high-output SPLs. The diseased ME is reconstructed with prostheses. These diseased ears frequently need additional amplification with hearing aids, and it is unclear if reconstruction itself leads to nonlinear ME responses. Methods: Eight fresh human cadaveric temporal bones were used. Pure tones of 70, 90, and 110 dB SPL at 500, 1,000, and 3,000 Hz were presented to the ear canal. Umbo and stapes displacements were measured by means of a laser Doppler vibrometer. After removing the incus, the tympanic membrane assembly to the stapes head prosthesis was placed, and measurements were repeated. Results: Stapes footplate vibrations in the reconstructed ears are 10 to 15 dB lower than those of the normal ears. In both normal and reconstructed ears, the footplate vibrations are linearly related to SPL at the tympanic membrane between 70 and 110 dB SPL at the frequencies tested. For the lever ratio, intact ears are more efficient at transmission of umbo vibrations to the stapes compared with reconstructed ears. Conclusion: To within acceptable limits, the ME seems to be linear between 70 and 110 dB SPL input levels, across the speech frequencies, and this does not change with reconstruction. The reconstructed human ME seems to have a less efficient lever ratio than the intact ME.
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| 25. |
- Mantovani Nardes, Alexandre, et al.
(author)
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A morphological model for the solvent-enhanced conductivity of PEDOT : PSS thin films
- 2008
-
In: Advanced Functional Materials. - : Wiley-VCH Verlag. - 1616-301X .- 1616-3028. ; 18:6, s. 865-871
-
Journal article (peer-reviewed)abstract
- The well-known enhanced conductivity of poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) thin films that is obtained by addition of high-boiling solvents like sorbitol to the aqueous dispersion used for film deposition is shown to be associated with a rearrangement of PEDOT-rich clusters into elongated domains, as evidenced from STM and AFM. Consistently, temperature dependent conductivity measurements for sorbitol-treated films reveal that charge transport occurs via quasi ID variable range hopping (VRH), in contrast to 3D VRH for untreated PEDOT:PSS films. The typical hopping distance of 60-90 nm, extracted from the conductivity measurements is consistent with hopping between the 30-40 nm sized grains observed with scanning probe microscopy.
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| 26. |
- Maturova, Klara, et al.
(author)
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Scanning Kelvin Probe Microscopy on Bulk Heterojunction Polymer Blends
- 2009
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In: Advanced Functional Materials. - : Wiley-VCH Verlag. - 1616-301X .- 1616-3028. ; 19:9, s. 1379-1386
-
Journal article (peer-reviewed)abstract
- Here, correlated AFM and scanning Kelvin probe microscopy measurements with sub-100 nm resolution on the phase-separated active layer of polymer-fullerene (MDMO-PPV:PCBM) bulk heterojunction solar cells in the dark and under illumination are described. Using numerical modeling a fully quantitative explanation for the contrast and shifts of the surface potential in dark and light is provided. Under illumination an excess of photogenerated electrons is present in both the donor and acceptor phases. From the time evolution of the surface potential after switching off the light the contributions of free and trapped electrons can be identified. Based on these measurements the relative 3D energy level shifts of the sample are calculated. Moreover, by comparing devices with fine and coarse phase separation, it is found that the inferior performance of the latter devices is, at least partially, due to poor electron transport.
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| 27. |
- Morris, David P, et al.
(author)
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Cochlear implantation in Cockayne syndrome: our experience of two cases with different outcomes.
- 2007
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In: The Laryngoscope. - 0023-852X. ; 117:5, s. 939-43
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Journal article (peer-reviewed)abstract
- Cockayne syndrome is a rare autosomal recessive defect in DNA repair resulting in a classic facies with potential visual and auditory impairment. The hearing loss begins peripherally and may become central as the condition progresses. Coexisting sensory deprivation from visual impairment and the possibility of progressive deterioration in mental function conspire with a lack of published experience to produce many challenges for the cochlear implant team. To the best of our knowledge, we present the first case reports with documented follow-up of cochlear implantation in two patients with different manifestations of Cockayne syndrome.
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| 28. |
- Sigurdsson, Snaevar, et al.
(author)
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Association of a Haplotype in the Promoter Region of the Interferon Regulatory Factor 5 Gene With Rheumatoid Arthritis
- 2007
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In: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 56:7, s. 2202-2210
-
Journal article (peer-reviewed)abstract
- Objective. To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA). Methods. Five single-nucleotide polymorphisms (SNPs) in IRF5 and 3 SNPs in Tyk2 were analyzed in a Swedish cohort of 1,530 patients with RA and 881 controls. A replication study was performed in a Dutch cohort of 387 patients with RA and 181 controls. All patient sera were tested for the presence of autoantibodies against cyclic citrullinated peptides (anti-CCP). Results. Four of the 5 SNPs located in the 5' region of IRF5 were associated with RA, while no association was observed with the Tyk2 SNPs. The minor alleles of 3 of the IRF5 SNPs, which were in linkage disequilibrium and formed a relatively common haplotype with a frequency of ∼0.33, appeared to confer protection against RA. Although these disease associations were seen in the entire patient group, they were mainly found in RA patients who were negative for anti-CCP. A suggestive association of IRF5 SNPs with anti-CCP-negative RA was also observed in the Dutch cohort. Conclusion. Given the fact that anti-CCP-negative RA differs from anti-CCP-positive RA with respect to genetic and environmental risk factor profiles, our results indicate that genetic variants of IRF5 contribute to a unique disease etiology and pathogenesis in anti-CCP-negative RA.
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| 29. |
- Stellingwerff, Trent, et al.
(author)
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Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies
- 2007
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In: American Journal of Physiology. Endocrinology and Metabolism. - Bethesda, MD : American Physiological Society. - 0193-1849 .- 1522-1555. ; 292:6, s. E1715-E1723
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Journal article (peer-reviewed)abstract
- Intramyocellular triacylglycerol (IMTG) has been suggested to represent an important substrate source during exercise. In the present study, IMTG utilization during exercise is assessed through the use of various methodologies. In addition, we identified differences in the use of intramyocellular lipids deposited in the immediate subsarcolemmal (SS) area and those stored in the more central region of the fiber. Contemporary stable isotope technology was applied in combination with muscle tissue sampling before and immediately after 3 h of moderate-intensity cycling exercise (62 ± 2% V̇o2 max) in eight well-trained male cyclists. Continuous infusions with [U-13C]palmitate and [6,6-2H2]glucose were applied to quantify plasma free fatty acid (FFA) and glucose oxidation rates and to estimate whole body IMTG and glycogen use. Both immunohistochemical analyses of oil red O (ORO)-stained muscle cross sections and biochemical triacylglycerol (TG) extraction were performed to assess muscle lipid content. During exercise, plasma FFA, muscle (and/or lipoprotein)-derived TG, plasma glucose, and muscle glycogen oxidation contributed 24 ± 2, 22 ± 3, 11 ± 1, and 43 ± 3% to total energy expenditure, respectively. In accordance, a significant net decline in muscle lipid content was observed following exercise as assessed by ORO staining (67 ± 8%) and biochemical TG extraction (49 ± 8%), and a positive correlation was observed between methods (r = 0.56; P < 0.05). Lipid depots located in the SS area were utilized to a greater extent than the more centrally located depots. This is the first study to show significant use of IMTG as a substrate source during exercise in healthy males via the concurrent implementation of three major methodologies. In addition, this study shows differences in resting subcellular intramyocellular lipid deposit distribution and in the subsequent net use of these deposits during exercise. Copyright © 2007 the American Physiological Society.
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- Stupp, Roger, et al.
(author)
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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
- 2005
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In: The New England journal of medicine. - 1533-4406. ; 352:10, s. 987-996
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Journal article (peer-reviewed)abstract
- BACKGROUND: Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety.METHODS: Patients with newly diagnosed, histologically confirmed glioblastoma were randomly assigned to receive radiotherapy alone (fractionated focal irradiation in daily fractions of 2 Gy given 5 days per week for 6 weeks, for a total of 60 Gy) or radiotherapy plus continuous daily temozolomide (75 mg per square meter of body-surface area per day, 7 days per week from the first to the last day of radiotherapy), followed by six cycles of adjuvant temozolomide (150 to 200 mg per square meter for 5 days during each 28-day cycle). The primary end point was overall survival.RESULTS: A total of 573 patients from 85 centers underwent randomization. The median age was 56 years, and 84 percent of patients had undergone debulking surgery. At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12.1 months with radiotherapy alone. The unadjusted hazard ratio for death in the radiotherapy-plus-temozolomide group was 0.63 (95 percent confidence interval, 0.52 to 0.75; P<0.001 by the log-rank test). The two-year survival rate was 26.5 percent with radiotherapy plus temozolomide and 10.4 percent with radiotherapy alone. Concomitant treatment with radiotherapy plus temozolomide resulted in grade 3 or 4 hematologic toxic effects in 7 percent of patients.CONCLUSIONS: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
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