| 1. |
|
|
| 2. |
- Niemi, MEK, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Kanai, M, et al.
(author)
-
- 2023
-
swepub:Mat__t
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Bousquet, J, et al.
(author)
-
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
-
In: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
-
Journal article (peer-reviewed)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
|
|
| 7. |
- Deline, A., et al.
(author)
-
The atmosphere and architecture of WASP-189 b probed by its CHEOPS phase curve
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 659
-
Journal article (peer-reviewed)abstract
- Context. Gas giants orbiting close to hot and massive early-type stars can reach dayside temperatures that are comparable to those of the coldest stars. These 'ultra-hot Jupiters' have atmospheres made of ions and atomic species from molecular dissociation and feature strong day-to-night temperature gradients. Photometric observations at different orbital phases provide insights on the planet's atmospheric properties. Aims. We aim to analyse the photometric observations of WASP-189 acquired with the Characterising Exoplanet Satellite (CHEOPS) to derive constraints on the system architecture and the planetary atmosphere. Methods. We implemented a light-curve model suited for an asymmetric transit shape caused by the gravity-darkened photosphere of the fast-rotating host star. We also modelled the reflective and thermal components of the planetary flux, the effect of stellar oblateness and light-travel time on transit-eclipse timings, the stellar activity, and CHEOPS systematics. Results. From the asymmetric transit, we measure the size of the ultra-hot Jupiter WASP-189 b, R-p = 1.600(-0.016)(+0.017)R(J), with a precision of 1%, and the true orbital obliquity of the planetary system, Psi(P) = 89.6 +/- 1.2 deg (polar orbit). We detect no significant hotspot offset from the phase curve and obtain an eclipse depth of delta ecl = 96.5(-5.9)(+4).(5) ppm, from which we derive an upper limit on the geometric albedo: A(g) < 0.48. We also find that the eclipse depth can only be explained by thermal emission alone in the case of extremely inefficient energy redistribution. Finally, we attribute the photometric variability to the stellar rotation, either through superficial inhomogeneities or resonance couplings between the convective core and the radiative envelope. Conclusions. Based on the derived system architecture, we predict the eclipse depth in the upcoming Transiting Exoplanet Survey Satellite (TESS) observations to be up to similar to 165 ppm. High-precision detection of the eclipse in both CHEOPS and TESS passbands might help disentangle reflective and thermal contributions. We also expect the right ascension of the ascending node of the orbit to precess due to the perturbations induced by the stellar quadrupole moment J(2) (oblateness).
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
- Carter, Aarynn L., et al.
(author)
-
A benchmark JWST near-infrared spectrum for the exoplanet WASP-39 b
- 2024
-
In: Nature Astronomy. - 2397-3366. ; In Press
-
Journal article (peer-reviewed)abstract
- A combined analysis of datasets across four JWST instrument modes provides a benchmark transmission spectrum for the Saturn-mass WASP-39 b. The broad wavelength range and high resolution constrain orbital and stellar parameters to below 1%.
|
|
| 13. |
- Bell, Taylor, et al.
(author)
-
Nightside clouds and disequilibrium chemistry on the hot Jupiter WASP-43b
- 2024
-
In: Nature Astronomy. - 2397-3366. ; In Press
-
Journal article (peer-reviewed)abstract
- Hot Jupiters are among the best-studied exoplanets, but it is still poorly understood how their chemical composition and cloud properties vary with longitude. Theoretical models predict that clouds may condense on the nightside and that molecular abundances can be driven out of equilibrium by zonal winds. Here we report a phase-resolved emission spectrum of the hot Jupiter WASP-43b measured from 5 μm to 12 μm with the JWST’s Mid-Infrared Instrument. The spectra reveal a large day–night temperature contrast (with average brightness temperatures of 1,524 ± 35 K and 863 ± 23 K, respectively) and evidence for water absorption at all orbital phases. Comparisons with three-dimensional atmospheric models show that both the phase-curve shape and emission spectra strongly suggest the presence of nightside clouds that become optically thick to thermal emission at pressures greater than ~100 mbar. The dayside is consistent with a cloudless atmosphere above the mid-infrared photosphere. Contrary to expectations from equilibrium chemistry but consistent with disequilibrium kinetics models, methane is not detected on the nightside (2σ upper limit of 1–6 ppm, depending on model assumptions). Our results provide strong evidence that the atmosphere of WASP-43b is shaped by disequilibrium processes and provide new insights into the properties of the planet’s nightside clouds. However, the remaining discrepancies between our observations and our predictive atmospheric models emphasize the importance of further exploring the effects of clouds and disequilibrium chemistry in numerical models.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Sguazzin, M., et al.
(author)
-
Indirect measurements of neutron -induced reaction cross sections at heavy -ion storage rings
- 2023
-
In: 15TH INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY, ND2022. - 2100-014X. ; 284
-
Conference paper (peer-reviewed)abstract
- Neutron-induced reaction cross sections of unstable nuclei are essential for understanding the synthesis of heavy elements in stars and for applications in nuclear technology. However, their measurement is very complicated due to the radioactivity of the targets involved. We propose to circumvent this problem by using the surrogate reaction method in inverse kinematics, where the nucleus formed in the neutroninduced reaction of interest is produced by a reaction involving a radioactive heavy -ion beam and a stable, light target nucleus. The probabilities as a function of the compound -nucleus excitation energy for y -ray emission, neutron emission and fission, which can be measured with the surrogate reaction, are particularly useful to constrain model parameters and to obtain more accurate predictions of the neutron-induced reaction cross sections of interest. Yet, the full development of the surrogate method is hampered by numerous longstanding target issues, which can be solved by combining surrogate reactions with the unique and largely unexplored possibilities at heavy -ion storage rings. In this contribution, we describe the developments we are carrying out to measure for the first time simultaneously y-ray emission, neutron emission and fission probabilities at the storage rings of the GSI/FAIR facility. In particular, we will present the first results of the proof of principle experiment, which we performed in June 2022 at the Experimental Storage Ring (ESR)
|
|
| 17. |
- Sguazzin, M., et al.
(author)
-
Indirect measurements of neutron-induced reaction cross sections at storage rings
- 2023
-
In: NUCLEAR PHYSICS IN ASTROPHYSICS - X, NPA-X 2022. - : EDP Sciences. - 2100-014X. ; 279
-
Conference paper (peer-reviewed)abstract
- Neutron-induced reaction cross sections of unstable nuclei are essential for understanding the synthesis of heavy elements in stars. However, their measurement is very difficult due to the radioactivity of the targets involved. We propose to circumvent this problem by using for the first time the surrogate reaction method in inverse kinematics at heavy-ion storage rings. In this contribution, we describe the developments we have done to perform surrogate-reaction studies at the storage rings of GSI/FAIR. In particular, we present the first results of the proof of principle experiment, which we conducted recently at the Experimental Storage Ring (ESR).
|
|
| 18. |
- Alligier, M, et al.
(author)
-
OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions
- 2020
-
In: Obesity facts. - : S. Karger AG. - 1662-4033 .- 1662-4025. ; 13:1, s. 1-28
-
Journal article (peer-reviewed)abstract
- Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing – focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals’ responses to an intervention for obesity – ultimately leading to better patient care and improved obesity outcomes.
|
|
| 19. |
- Bousquet, Jean, et al.
(author)
-
ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
-
In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
-
Research review (peer-reviewed)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
- Clark, Timothy D., et al.
(author)
-
Ocean acidification does not impair the behaviour of coral reef fishes
- 2020
-
In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 577:7790, s. 370-375
-
Journal article (peer-reviewed)abstract
- The partial pressure of CO2 in the oceans has increased rapidly over the past century, driving ocean acidification and raising concern for the stability of marine ecosystems1,2,3. Coral reef fishes are predicted to be especially susceptible to end-of-century ocean acidification on the basis of several high-profile papers4,5 that have reported profound behavioural and sensory impairments—for example, complete attraction to the chemical cues of predators under conditions of ocean acidification. Here, we comprehensively and transparently show that—in contrast to previous studies—end-of-century ocean acidification levels have negligible effects on important behaviours of coral reef fishes, such as the avoidance of chemical cues from predators, fish activity levels and behavioural lateralization (left–right turning preference). Using data simulations, we additionally show that the large effect sizes and small within-group variances that have been reported in several previous studies are highly improbable. Together, our findings indicate that the reported effects of ocean acidification on the behaviour of coral reef fishes are not reproducible, suggesting that behavioural perturbations will not be a major consequence for coral reef fishes in high CO2 oceans.
|
|
| 23. |
- Pathak, P., et al.
(author)
-
High-contrast imaging at ten microns : A search for exoplanets around Eps Indi A, Eps Eri, Tau Ceti, Sirius A, and Sirius B
- 2021
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 652
-
Journal article (peer-reviewed)abstract
- Context. The direct imaging of rocky exoplanets is one of the major science goals of upcoming large telescopes. The contrast requirement for imaging such planets is challenging. However, the mid-IR (infrared) regime provides the optimum contrast to directly detect the thermal signatures of exoplanets in our solar neighbourhood.Aims. We aim to exploit novel fast-chopping techniques newly developed for astronomy with the aid of adaptive optics to look for thermal signatures of exoplanets around bright stars in the solar neighbourhood.Methods. We used the upgraded Very Large Telescope Imager and Spectrometer for the mid-InfraRed (VISIR) instrument with high-contrast imaging capability optimised for observations at 10 μm to look for exoplanets around five nearby (d < 4 pc) stars. The instrument provides an improved signal-to-noise ratio (S/N) by a factor of ~4 in the N-band compared to standard VISIR for a given S/N and time.Results. In this work, we achieve a detection sensitivity of sub-mJy, which is sufficient to detect a few Jupiter mass planets in nearby systems. Although no detections are made, we achieve most sensitive limits within <2″ for all the observed targets compared to previous campaigns. For ϵ Indi A and ϵ Eri, we achieve detection limits very close to the giant planets discovered by RV, with the limits on ϵ Indi A being the most sensitive to date. Our non-detection therefore supports an older age for ϵ Indi A. The results presented here are promising for high-contrast imaging and exoplanet detections in the mid-IR regime.
|
|
| 24. |
- Peugeot, A., et al.
(author)
-
Generating Two Continuous Entangled Microwave Beams Using a dc-Biased Josephson Junction
- 2021
-
In: Physical Review X. - 2160-3308. ; 11:3
-
Journal article (peer-reviewed)abstract
- We show experimentally that a dc-biased Josephson junction in series with two microwave resonators emits entangled beams of microwaves leaking out of the resonators. In the absence of a stationary phase reference for characterizing the entanglement of the outgoing beams, we measure second-order coherence functions to prove the entanglement. The experimental results are found in quantitative agreement with theory, proving that the low-frequency noise of the dc bias is the main limitation for the coherence time of the entangled beams. This agreement allows us to evaluate the entropy of entanglement of the resonators, estimate the entanglement flux at their output, and to identify the improvements that could bring this device closer to a useful bright source of entangled microwaves for quantum-technological applications.
|
|
| 25. |
- Roche, A. D., et al.
(author)
-
Upper limb prostheses: bridging the sensory gap
- 2023
-
In: Journal of Hand Surgery-European Volume. - : SAGE Publications. - 1753-1934 .- 2043-6289. ; 48:3, s. 182-190
-
Journal article (peer-reviewed)abstract
- Replacing human hand function with prostheses goes far beyond only recreating muscle movement with feedforward motor control. Natural sensory feedback is pivotal for fine dexterous control and finding both engineering and surgical solutions to replace this complex biological function is imperative to achieve prosthetic hand function that matches the human hand. This review outlines the nature of the problems underlying sensory restitution, the engineering methods that attempt to address this deficit and the surgical techniques that have been developed to integrate advanced neural interfaces with biological systems. Currently, there is no single solution to restore sensory feedback. Rather, encouraging animal models and early human studies have demonstrated that some elements of sensation can be restored to improve prosthetic control. However, these techniques are limited to highly specialized institutions and much further work is required to reproduce the results achieved, with the goal of increasing availability of advanced closed loop prostheses that allow sensory feedback to inform more precise feedforward control movements and increase functionality.
|
|
| 26. |
- Sguazzin, M., et al.
(author)
-
Determining neutron-induced reaction cross sections through surrogate reactions at storage rings
- 2023
-
In: Journal of Physics: Conference Series. - 1742-6588 .- 1742-6596. ; 2586:1
-
Conference paper (peer-reviewed)abstract
- Determining the cross sections of neutron-induced reactions on short-lived nuclei is imperative to rate calculations in stellar nucleosynthesis and applications of nuclear physics. It is also an immense experimental challenge due to the radioactivity of the targets involved. Our goal is to circumvent this obstacle by using surrogate reactions in inverse kinematics at the heavy-ion storage rings of GSI/FAIR. We present here preliminary results from the first proof of principle experiment, where a beam of 208Pb impinged on a H2 gas jet target in the Experimental Storage Ring (ESR).
|
|
| 27. |
- Vacelet, L, et al.
(author)
-
Insulin Resistance and Type 2 Diabetes in Asymptomatic Obstructive Sleep Apnea: Results of the PROOF Cohort Study After 7 Years of Follow-Up
- 2021
-
In: Frontiers in physiology. - : Frontiers Media SA. - 1664-042X. ; 12, s. 650758-
-
Journal article (peer-reviewed)abstract
- The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort study (n = 1,011). After 7 years follow-up, 494 subjects underwent assessment of fasting insulin and glucose levels. OSA was defined by an apnea-hypopnea index (AHI) of ≥15/h using polygraphy. Diabetes mellitus was defined by a fasting glucose ≥ 1.26 g/L and/or when requiring pharmacological treatment, while insulin resistance corresponded to HOMA-IR ≥ 2. Asymptomatic OSA subjects (men or women) did not display increased risk of incident diabetes (2.8 vs. 3.9%, p = 0.51). However, there was a greater frequency of insulin resistance in subjects with severe OSA (AHI > 30) [OR 2.21; 95% CI (1.22–4.02); p = 0.009]. Furthermore, multiple logistic regression showed that triglycerides levels [OR 1.61; 95% CI (1.10–2.36); p = 0.01] and fasting glycaemia [OR 4.69; 95% CI (1.12–192.78); p = 0.04], but not AHI or oxyhemoglobin desaturation index were independently associated with higher rate of insulin resistance. The deleterious metabolic effect of asymptomatic OSA in the population may be indirectly mediated via perturbations in lipids, and is particularly likely to become manifest in severe apneic subjects with higher glycemic levels.
|
|
| 28. |
|
|
| 29. |
- Barthelemy, JC, et al.
(author)
-
Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke
- 2022
-
In: Frontiers in aging neuroscience. - : Frontiers Media SA. - 1663-4365. ; 14, s. 969352-
-
Journal article (peer-reviewed)abstract
- Stroke prediction is a key health issue for preventive medicine. Atrial fibrillation (AF) detection is well established and the importance of obstructive sleep apneas (OSA) has emerged in recent years. Although autonomic nervous system (ANS) appears strongly implicated in stroke occurrence, this factor is more rarely considered. However, the consequences of decreased parasympathetic activity explored in large cohort studies through measurement of ANS activity indicate that an ability to improve its activity level and equilibrium may prevent stroke. In support of these observations, a compensatory neurostimulation has already proved beneficial on endothelium function. The available data on stroke predictions from ANS is based on many long-term stroke cohorts. These data underline the need of repeated ANS evaluation for the general population, in a medical environment, and remotely by emerging telemedicine digital tools. This would help uncovering the reasons behind the ANS imbalance that would need to be medically adjusted to decrease the risk of stroke. This ANS unbalance help to draw attention on clinical or non-clinical evidence, disclosing the vascular risk, as ANS activity integrates the cumulated risk from many factors of which most are modifiable, such as metabolic inadaptation in diabetes and obesity, sleep ventilatory disorders, hypertension, inflammation, and lack of physical activity. Treating these factors may determine ANS recovery through the appropriate management of these conditions. Natural aging also decreases ANS activity. ANS recovery will decrease global circulating inflammation, which will reinforce endothelial function and thus protect the vessels and the associated organs. ANS is the whistle-blower of vascular risk and the actor of vascular health. Such as, ANS should be regularly checked to help draw attention on vascular risk and help follow the improvements in response to our interventions. While today prediction of stroke relies on classical cardiovascular risk factors, adding autonomic biomarkers as HRV parameters may significantly increase the prediction of stroke.
|
|
| 30. |
|
|
| 31. |
- Colas, C, et al.
(author)
-
Efficiency of an Optimized Care Organization in Fibromyalgia Patients: The From Intent to Move (FIMOUV) Study Protocol of a Randomized Controlled Trial
- 2021
-
In: Frontiers in public health. - : Frontiers Media SA. - 2296-2565. ; 9, s. 554291-
-
Journal article (peer-reviewed)abstract
- Introduction: Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure the effectiveness of a healthcare organization offering a specific program of adapted physical activity combined with a therapeutic education program for FM patients.Methods and Analysis: The From Intent To Move (FIMOUV) study will recruit 330 FM patients randomized into two groups: test and control. The test group will benefit from a 1-month mixed exercise training program supervised at the hospital, followed by 2 months in a community-based relay in a health-sport structure. In addition, each of the two groups will benefit from therapeutic patient education sessions. The main endpoint is the measurement of the level of physical activity by accelerometry at 1 year. The secondary endpoints concern adherence to the practice of physical activity, impact on lifestyle, state of health, and physical capacity, as well as an estimate of the budgetary impact of this management strategy.Discussion: This interventional research will allow us to assess the evolution of behaviors in physical activity after an FM syndrome management based solely on patient education or based on a supervised and adapted practice of physical activity associated with this same therapeutic education program. It seems to be the first study evaluating the impact of its intervention on objective data for measuring physical activity and sedentary behavior via accelerometry among FM patients.Trial registration:ClinicalTrials.gov NCT04107948.
|
|
| 32. |
- Donnan, F. R., et al.
(author)
-
A detailed look at the most obscured galactic nuclei in the mid-infrared
- 2023
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 669
-
Journal article (peer-reviewed)abstract
- Context. Compact obscured nuclei (CONs) represent an extreme phase of galaxy evolution where rapid supermassive black hole growth and/or compact star-forming activity is completely obscured by gas and dust. Aims. We investigate the properties of CONs in the mid-infrared and explore techniques aimed at identifying these objects, such as through the equivalent width (EW) ratios of their polycyclic aromatic hydrocarbon (PAH) features. Methods. We modelled Spitzer spectra by decomposing the continua into nuclear and star-forming components, from which we then measured the nuclear optical depth, τN, of the 9.8 μm silicate absorption feature. We also used Spitzer spectral maps to investigate how PAH EW ratios vary with aperture size for objects that host CONs. Results. We find that the nuclear optical depth, τN, strongly correlates with the HCN-vib emission line in the millimetre for CONs, with a Pearson correlation coefficient of 0.91. We find the PAH EW ratio technique to be effective at selecting CONs and robust against highly inclined galaxies, where strong dust lanes may mimic a CON-like spectrum by producing a high τN. Our analysis of the Spitzer spectral maps shows that the efficacy of the PAH EW ratios in isolating CONs is reduced when there is a strong starforming component from the host galaxy. In addition, we find that the use of the inferred nuclear optical depth is a reliable method for identifying CONs in 36+8-7% of ultra-luminous infrared galaxies and 17+3-3% of luminous infrared galaxies, consistent with previous work. Conclusions. We confirm mid-infrared spectra to be a powerful diagnostic of CONs. The increased sensitivity of JWST will allow the identification of CONs at cosmic noon, revealing this extreme but hidden phase of galaxy evolution.
|
|
| 33. |
|
|
| 34. |
|
|
| 35. |
- Esparza-Borges, E., et al.
(author)
-
Detection of Carbon Monoxide in the Atmosphere of WASP-39b Applying Standard Cross-correlation Techniques to JWST NIRSpec G395H Data
- 2023
-
In: Astrophysical Journal Letters. - 2041-8213 .- 2041-8205. ; 955:1
-
Journal article (peer-reviewed)abstract
- Carbon monoxide was recently reported in the atmosphere of the hot Jupiter WASP-39b using the NIRSpec PRISM transit observation of this planet, collected as part of the JWST Transiting Exoplanet Community Early Release Science Program. This detection, however, could not be confidently confirmed in the initial analysis of the higher-resolution observations with NIRSpec G395H disperser. Here we confirm the detection of CO in the atmosphere of WASP-39b using the NIRSpec G395H data and cross-correlation techniques. We do this by searching for the CO signal in the unbinned transmission spectrum of the planet between 4.6 and 5.0 μm, where the contribution of CO is expected to be higher than that of other anticipated molecules in the planet’s atmosphere. Our search results in a detection of CO with a cross-correlation function (CCF) significance of 6.6σ when using a template with only 12C16O lines. The CCF significance of the CO signal increases to 7.5σ when including in the template lines from additional CO isotopologues, with the largest contribution being from 13C16O. Our results highlight how cross-correlation techniques can be a powerful tool for unveiling the chemical composition of exoplanetary atmospheres from medium-resolution transmission spectra, including the detection of isotopologues.
|
|
| 36. |
|
|
| 37. |
- Fanget, M, et al.
(author)
-
Effects of Cardiac Telerehabilitation During COVID-19 on Cardiorespiratory Capacities in Patients With Coronary Artery Disease
- 2022
-
In: Frontiers in physiology. - : Frontiers Media SA. - 1664-042X. ; 13, s. 837482-
-
Journal article (peer-reviewed)abstract
- The COVID-19 pandemic led to the closure of most cardiac therapy centers. One of the solutions was to adapt the existing cardiac rehabilitation (CR) program in an institute to a remote approach offered by home-based telerehabilitation. The aim of this study was to measure the cardiorespiratory effects of telerehabilitation compared to conventional center-based CR.MethodsPatients were assigned to two 3-week CR programs: telerehabilitation and conventional center-based CR. The telerehabilitation group wore a connected watch to monitor heart rate (HR) and gave their perception of effort according to a modified Borg scale. The exercise training (four sessions/week) consisted of 1-h aerobic endurance and strength training session at the target HR zone determined by results based on cardiopulmonary exercise test (CPET) and perception of effort, respectively. The exercise protocol was the same for conventional CR participants except the duration of session that lasted 2 h instead of one. The week before and after the training program, peak oxygen uptake (VO2 peak), oxygen uptake at first ventilatory threshold (VO2 at VT1), peak workload, percent of predicted maximum HR, and the absolute differences in HR and systolic blood pressure between maximum and recovery at 1 and 3 min were measured using a CPET. A two-way ANOVA with one repeated measure and one independent factor was performed.ResultsFifty-four patients (mean age: 61.5 ± 8.6 years, 10 women) equally split in the two groups were included in this experiment. A significant increase was observed in both groups on VO2 peak (telerehabilitation: 8.1 ± 7.8% vs. conventional: 10.1 ± 9.7%, p < 0.001), VO2 at VT1 (telerehabilitation: 8.8 ± 4.4% vs. conventional: 7.3 ± 19.0%, p = 0.02) and peak workload (telerehabilitation: 16.6 ± 18.9% vs. conventional: 17.2 ± 7.0%, p < 0.001) after the 3-week telerehabilitation and conventional CR, respectively. No significant difference was noticed between both groups.ConclusionA 3-week exercise program improved patients’ cardiorespiratory fitness. Telerehabilitation was as effective and represents a safe alternative CR program during the COVID-19 period. In the future, this approach could facilitate the continuity of care for patients unable to participate in center-based CR.
|
|
| 38. |
- Garcia-Bernete, I., et al.
(author)
-
A technique to select the most obscured galaxy nuclei
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 663
-
Journal article (peer-reviewed)abstract
- Compact obscured nuclei (CONs) are mainly found in local luminous and ultraluminous infrared galaxies (U/LIRGs). In the local Universe, these sources are generally selected through the detection of the HCN-vib (3-2) emission line at submillimetre wavelengths. In this work, we present a diagnostic method to select deeply buried nuclei based on mid-infrared (mid-IR) polycyclic aromatic hydrocarbons (PAHs) and mid-IR continuum ratios. Using Spitzer InfraRed Spectrograph (IRS) spectra of a representative sample of local ULIRGs (z < 0.27), we examine their PAH and underlying continuum emission ratios. For deeply embedded sources, we find that the 9.7 mu m silicate absorption band has a particularly pronounced effect on the 11.3 mu m PAH feature. The low flux level in the nuclear silicate absorption band enhances the 11.3 mu m PAH feature contrast (high PAH equivalent width) compared to that of the other PAH features. The technique has been extended to include the use of the underlying 11.3/12.7 and 11.3/6.2 mu m continuum ratios. However, the latter are affected by the extinction coming from both the host galaxy and the nuclear region, whereas the foreground (host-galaxy) extinction is cancelled out when using the PAH equivalent width ratios. We apply our method to local U/LIRGs from the HERUS and GOALS samples and classify 14 ULIRGs and 10 LIRGs as CON candidates, which corresponds to 30% of the ULIRGs and 7% of the LIRGs from these samples. We find that the observed continuum ratios of CON-dominated sources can be explained by assuming torus models with a tapered disc geometry and a smooth dust distribution. This suggests that the nuclear dusty structure of deeply obscured galaxy nuclei has an extremely high dust coverage. Finally, we demonstrate that the use of mid-IR colour-colour diagrams is an e ffective way to select CON-dominated sources at different redshifts. In particular, the combination of filters of the James Webb Space Telescope/Mid-Infrared Instrument will enable the selection of CONs out to z similar to 1.5. This will allow the selection of CONs to be extended to high redshifts where U/LIRGs are more numerous.
|
|
| 39. |
|
|
| 40. |
- Goethals, L, et al.
(author)
-
Social Marketing Intervention to Engage Older Adults in Balance Workshops for Fall Prevention: A Multicenter Quasi-Experimental Protocol Study
- 2021
-
In: Frontiers in public health. - : Frontiers Media SA. - 2296-2565. ; 9, s. 614119-
-
Journal article (peer-reviewed)abstract
- Background: Falls affects one of three people after 65 years old, and it can lead to serious consequences. Scientific evidence point out that physical exercise is the most efficient way to prevent falls among older adults.Objective: The main objective of this study is to determine if a social marketing program can increase the attendance rate of people aged 60 and over at group balance workshops.Methods: This quasi-experimental multicenter study is being conducted in three French Regions (Loire, Haute-Loire and Rhône) over a period of 18 months. The Social Marketing Campaign will be done in three ways. Firstly, a Communication Campaign will take place in the two Test Areas but not in the Control Area. Secondly, flyers have been designed to be distributed by local partners. Finally, conferences for older people will be organized in the areas of intervention in order to reach the target audience for the program. The study will include people aged 60 and older who want to participate in the Balance Program.Results: The Crédit Agricole Loire/Haute-Loire Foundation funded the study and the Jean Monnet University of Saint-Etienne reviewed it. The Ethics Committee of the University Teaching Hospital of Saint-Etienne approved and peer-reviewed it on September 6, 2019, under Reference Number IRBN622019/CHUSTE.Conclusion: The results of this first study will demonstrate whether or not social marketing for promoting group balance workshops in the elderly will increase their attendanceship in adapted physical activity sessions, especially those that prevent falls.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT04136938, identifier NCT04136938.
|
|
| 41. |
|
|
| 42. |
|
|
| 43. |
- Ivanov, Alexander G., et al.
(author)
-
The decreased PG content of pgp1 inhibits PSI photochemistry and limits reaction center and light-harvesting polypeptide accumulation in response to cold acclimation
- 2022
-
In: Planta. - : Springer. - 0032-0935 .- 1432-2048. ; 255:2
-
Journal article (peer-reviewed)abstract
- Main conclusion: Decreased PG constrains PSI activity due to inhibition of transcript and polypeptide abundance of light-harvesting and reaction center polypeptides generating a reversible, yellow phenotype during cold acclimation of pgp1.Cold acclimation of the Arabidopsis pgp1 mutant at 5 °C resulted in a pale-yellow phenotype with abnormal chloroplast ultrastructure compared to its green phenotype upon growth at 20 °C despite a normal cold-acclimation response at the transcript level. In contrast, wild type maintained its normal green phenotype and chloroplast ultrastructure irrespective of growth temperature. In contrast to cold acclimation of WT, growth of pgp1 at 5 °C limited the accumulation of Lhcbs and Lhcas assessed by immunoblotting. However, a novel 43 kD polypeptide of Lhcb1 as well as a 29 kD polypeptide of Lhcb3 accumulated in the soluble fraction which was absent in the thylakoid membrane fraction of cold-acclimated pgp1 which was not observed in WT. Cold acclimation of pgp1 destabilized the Chl–protein complexes associated with PSI and predisposed energy distribution in favor of PSII rather than PSI compared to the WT. Functionally, in vivo PSI versus PSII photochemistry was inhibited in cold-acclimated pgp1 to a greater extent than in WT relative to controls. Greening of the pale-yellow pgp1 was induced when cold-acclimated pgp1 was shifted from 5 to 20 °C which resulted in a marked decrease in excitation pressure to a level comparable to WT. Concomitantly, Lhcbs and Lhcas accumulated with a simultaneous decrease in the novel 43 and 29kD polypeptides. We conclude that the reduced levels of phosphatidyldiacylglycerol in the pgp1 limit the capacity of the mutant to maintain the structure and function of its photosynthetic apparatus during cold acclimation. Thus, maintenance of normal thylakoid phosphatidyldiacylglycerol levels is essential to stabilize the photosynthetic apparatus during cold acclimation.
|
|
| 44. |
- Jabakhanji, S. B., et al.
(author)
-
Public Health Measures to Address the Impact of Climate Change on Population Health-Proceedings from a Stakeholder Workshop
- 2022
-
In: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1660-4601. ; 19:20
-
Journal article (peer-reviewed)abstract
- Background: The World Health Organization identified climate change as the 21st century's biggest health threat. This study aimed to identify the current knowledge base, evidence gaps, and implications for climate action and health policymaking to address the health impact of climate change, including in the most underserved groups. Methods: The Horizon-funded project ENBEL ('Enhancing Belmont Research Action to support EU policy making on climate change and health') organised a workshop at the 2021-European Public Health conference. Following presentations of mitigation and adaptation strategies, seven international researchers and public health experts participated in a panel discussion linking climate change and health. Two researchers transcribed and thematically analysed the panel discussion recording. Results: Four themes were identified: (1) 'Evidence is key' in leading the climate debate, (2) the need for 'messaging about health for policymaking and behaviour change' including health co-benefits of climate action, (3) existing 'inequalities between and within countries', and (4) 'insufficient resources and funding' to implement national health adaptation plans and facilitate evidence generation and climate action, particularly in vulnerable populations. Conclusion: More capacity is needed to monitor health effects and inequities, evaluate adaptation and mitigation interventions, address current under-representations of low- or middle-income countries, and translate research into effective policymaking.
|
|
| 45. |
|
|
| 46. |
- Labeix, P, et al.
(author)
-
Resistance Training of Inspiratory Muscles After Coronary Artery Disease May Improve Obstructive Sleep Apnea in Outpatient Cardiac Rehabilitation: RICAOS Study
- 2022
-
In: Frontiers in physiology. - : Frontiers Media SA. - 1664-042X. ; 13, s. 846532-
-
Journal article (peer-reviewed)abstract
- Obstructive sleep apnea (OSA) affects 5% of the adult population and its prevalence is up to 13 times higher in coronary artery disease (CAD) patients. However, OSA in this population is less symptomatic, leading to lower adherence to positive airway pressure (CPAP). While oropharyngeal exercise showed a significant decrease in apnea-hypopnea index (AHI) in patients with moderate OSA, there have been no studies testing the impact of specific inspiratory muscle training (IMT) for these patients. The aim of our study was to assess the effectiveness of IMT on AHI reduction in CAD patients with moderate OSA.MethodsWe included patients with CAD involved in a cardiac rehabilitation program and presenting an AHI between 15 and 30. Patients were randomized in a 1:1 allocation to a control group (CTL – classic training) or an IMT group (classic training + IMT). IMT consisted in 60 deep inspirations a day, 6 days a week, into a resistive load device set at 70% of the maximum inspiratory pressure (MIP). After 6 weeks, we compared AHI, neck circumference, Epworth Sleepiness Scale, Pittsburgh Sleep Quality index, and quality of life with the 12-item Short Form Survey before and after rehabilitation.ResultsWe studied 45 patient (60 ± 9 y, BMI = 27 ± 6 kg.m−2). The IMT group (n = 22) significantly improved MIP ( p < 0.05) and had a significant decrease in AHI by 25% (−6.5 ± 9.5, p = 0.02). In the CTL group (n = 23), AHI decreased only by 3.5% (−0.7 ± 13.1; p = 0.29). Between groups, we found a significant improvement in MIP ( p = 0.003) and neck circumference ( p = 0.01) in favor of the IMT group. However, we did not find any significant improvement of AHI in the IMT group compared to CTL ( p = 0.09).ConclusionA specific IMT during cardiac rehabilitation contributes to reduce significantly AHI in CAD patients with moderate OSA. Magnitude of the decrease in OSA severity could be enhanced according to implementation of specific IMT in this population.
|
|
| 47. |
- Lee, Bruce Y., et al.
(author)
-
Research gaps and opportunities in precision nutrition : an NIH workshop report
- 2022
-
In: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 116:6, s. 1877-1900
-
Journal article (peer-reviewed)abstract
- Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health status, behaviors, social influences, and environmental exposures. On 11-12 January 2021, the National Institutes of Health convened a workshop entitled "Precision Nutrition: Research Gaps and Opportunities" to bring together experts to discuss the issues involved in better understanding and addressing precision nutrition. The workshop proceeded in 3 parts: part I covered many aspects of genetics and physiology that mediate the links between nutrient intake and health conditions such as cardiovascular disease, Alzheimer disease, and cancer; part II reviewed potential contributors to interindividual variability in dietary exposures and responses such as baseline nutritional status, circadian rhythm/sleep, environmental exposures, sensory properties of food, stress, inflammation, and the social determinants of health; part III presented the need for systems approaches, with new methods and technologies that can facilitate the study and implementation of precision nutrition, and workforce development needed to create a new generation of researchers. The workshop concluded that much research will be needed before more precise nutrition recommendations can be achieved. This includes better understanding and accounting for variables such as age, sex, ethnicity, medical history, genetics, and social and environmental factors. The advent of new methods and technologies and the availability of considerably more data bring tremendous opportunity. However, the field must proceed with appropriate levels of caution and make sure the factors listed above are all considered, and systems approaches and methods are incorporated. It will be important to develop and train an expanded workforce with the goal of reducing health disparities and improving precision nutritional advice for all Americans.
|
|
| 48. |
- Lynch, K. A., et al.
(author)
-
Suggestions for modifications to the Female Sexual Function Index based on cognitive interviews with sexual and gender minority individuals and cisgender, heterosexual persons
- 2023
-
In: Journal of Sexual Medicine. - 1743-6095 .- 1743-6109. ; 20:6, s. 871-877
-
Journal article (peer-reviewed)abstract
- Background Patient-reported outcome measures for sexual health were often designed for research studies that included only heterosexual, partnered, and cisgender participants; as such, they may have limited applicability for clinical use among sexual and gender minority (SGM) individuals or those without a partner.Aim We aimed to conduct cognitive interviews with SGM persons and heterosexual women to determine the readability, comprehension, and applicability of questionnaire items to assess sexual function among diverse sexual and gender identities.Methods We conducted 4 rounds of cognitive interviews with 52 participants (28 SGM; 24 cisgender, heterosexual) who provided feedback on the comprehension and wording of questionnaire items and response scales. We used items from the Female Sexual Function Index (FSFI) and focused on establishing content validity of a modified measure. Participants made recommendations for changes to the questionnaire, which was iteratively revised between interview rounds. Two independent coders analyzed the transcripts using structural coding based on 5 predefined codes: satisfaction with item, specificity/language change needed, missing/suggested item, patient definitions of concepts, and confusion with item.Outcomes Content validity.Results After 3 rounds of cognitive interviews and revisions to the questionnaire, participants found the final version acceptable and understandable, thereby reaching thematic saturation and establishing content validity of the modified FSFI. Modifications included the following: replacing all instances of "sexual stimulation" and "intercourse" with "sexual activity (alone or with a partner)," broadening the definition of "vaginal penetration" beyond penile-vaginal penetration, and adding skip logic to include the option "no sexual activity." Participants identified missing concepts important to their sexual health, such as use of an external lubricant.Clinical Implications The FSFI and similar questionnaires need to be adapted to broader clinical practice populations such that all persons' experiences are accurately reflected and assessed, ensuring that sexual health needs can be met more inclusively.Strength and Limitations A strength of the study was using cognitive interviews engaging patient perspectives, which is considered the gold standard for establishing content validity. One limitation is that participants included predominantly White and highly educated women.Conclusion Feedback from interviews supports modifying FSFI items and further psychometric testing, and future studies should evaluate the measure among racially and educationally diverse groups.
|
|
| 49. |
|
|
| 50. |
- Norin, Tommy, et al.
(author)
-
Predator presence affects activity patterns but not food consumption or growth of juvenile corkwing wrasse (Symphodus melops)
- 2021
-
In: Behavioral Ecology and Sociobiology. - : Springer. - 0340-5443 .- 1432-0762. ; 75:1
-
Journal article (peer-reviewed)abstract
- Indirect effects of predators can manifest themselves as changes in prey behaviour and physiology. Given that digestion requires energy, it has been suggested that prey will choose to eat smaller meals under predation risk to reserve a larger portion of the aerobic metabolic scope they have available for energetically demanding tasks more critical than digestion, such as escape. To test this prediction, we quantified food consumption and growth of juvenile corkwing wrasses (Symphodus melops) over 11 days in the presence or absence of a predator (Atlantic cod, Gadus morhua). We then quantified behaviour and food consumption of the same wrasses in behavioural arenas with a predator. All food consumption was examined in the context of the aerobic scope that would have been available during the digestive period. Overall, there was no effect of predator exposure on food consumption or growth, yet predator-exposed wrasses were more consistent in their daily food consumption, lending some support to our prediction of prey bet-hedging on meal size under predation risk. The lack of a clear pattern may have resulted from a relatively low percentage of aerobic scope (similar to 20-27%) being occupied by digestion, such that fish retained ample capacity for activities other than digestion. In the subsequent behavioural trials, predator-exposed wrasses were more active and spent more time near the cod than predator-naive wrasses, suggesting the former had habituated to predation threat and were more risk-taking. Our results highlight the complex and often counter-intuitive effects that predator presence can have on prey populations beyond direct consumption. Significance statement Predators affect the behaviour of prey species by simply being present in the environment. Such intimidation by predators can change activity patterns of prey and be as important as direct predation for ecosystem dynamics. However, compared to behavioural changes, we know little about how predators indirectly affect prey physiology. We investigated if fish deliberately eat less food when a predator is present, in order to retain sufficient physiological capacity for avoiding a potential attack, on top of the energetically costly process of digesting. While our study confirms that predator encounters reduce prey activity, prey fish appeared to rapidly habituate to predator presence and we did not see reduced food consumption in predator-exposed fish; these were, however, more consistent than unexposed fish in their daily food consumption, suggesting that fish may still be mindful about protecting their aerobic capacity under predation risk.
|
|
