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Träfflista för sökning "WFRF:(Rowlands G) srt2:(2005-2009)"

Search: WFRF:(Rowlands G) > (2005-2009)

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1.
  • Jallow, Muminatou, et al. (author)
  • Genome-wide and fine-resolution association analysis of malaria in West Africa.
  • 2009
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; , s. 657-665
  • Journal article (peer-reviewed)abstract
    • We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 x 10(-7) to P = 4 x 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.
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2.
  • Moslem, WM, et al. (author)
  • Solitary, explosive, and periodic solutions of the quantum Zakharov-Kuznetsov equation and its transverse instability
  • 2007
  • In: Physics of Plasmas. - Melville : American Institute of Physics (AIP). - 1070-664X .- 1089-7674. ; 14:8
  • Journal article (peer-reviewed)abstract
    • By employing the quantum hydrodynamic model and the reductive perturbation technique, a quantum Zakharov-Kuznetsov (QZK) equation is derived for finite but small amplitude ion-acoustic waves in a quantum magnetoplasma. The extended Conte's truncation method is used to obtain the solitary, explosive, and periodic solutions of the QZK equation. Furthermore, the stability of the solitary wave solution of the QZK equation is investigated by using the small-k perturbation expansion method.
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