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Träfflista för sökning "WFRF:(Schaeffer Stephen W.) srt2:(2020-2023)"

Search: WFRF:(Schaeffer Stephen W.) > (2020-2023)

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1.
  • Abbafati, Cristiana, et al. (author)
  • 2020
  • Journal article (peer-reviewed)
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2.
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3.
  • Kapun, Martin, et al. (author)
  • Drosophila Evolution over Space and Time (DEST) : A New Population Genomics Resource
  • 2021
  • In: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 38:12, s. 5782-5805
  • Journal article (peer-reviewed)abstract
    • Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural populations of this species have been published over the last years. A major challenge is the integration of disparate data sets, often generated using different sequencing technologies and bioinformatic pipelines, which hampers our ability to address questions about the evolution of this species. Here we address these issues by developing a bioinformatics pipeline that maps pooled sequencing (Pool-Seq) reads from D. melanogaster to a hologenome consisting of fly and symbiont genomes and estimates allele frequencies using either a heuristic (PoolSNP) or a probabilistic variant caller (SNAPE-pooled). We use this pipeline to generate the largest data repository of genomic data available for D. melanogaster to date, encompassing 271 previously published and unpublished population samples from over 100 locations in >20 countries on four continents. Several of these locations have been sampled at different seasons across multiple years. This data set, which we call Drosophila Evolution over Space and Time (DEST), is coupled with sampling and environmental metadata. A web-based genome browser and web portal provide easy access to the SNP data set. We further provide guidelines on how to use Pool-Seq data for model-based demographic inference. Our aim is to provide this scalable platform as a community resource which can be easily extended via future efforts for an even more extensive cosmopolitan data set. Our resource will enable population geneticists to analyze spatiotemporal genetic patterns and evolutionary dynamics of D. melanogaster populations in unprecedented detail.
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4.
  • Berdan, Emma L, 1983, et al. (author)
  • How chromosomal inversions reorient the evolutionary process
  • 2023
  • In: Journal of Evolutionary Biology. - 1010-061X .- 1420-9101. ; 36:12, s. 1761-1782
  • Research review (peer-reviewed)abstract
    • Inversions are structural mutations that reverse the sequence of a chromosome seg-ment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation, as well as in other evolutionary processes such as spe-ciation. Although inversions have been studied since the 1920s, they remain difficult to investigate because the reduced recombination conferred by them strengthens the effects of drift and hitchhiking, which in turn can obscure signatures of selection. Nonetheless, numerous inversions have been found to be under selection. Given re-cent advances in population genetic theory and empirical study, here we review how different mechanisms of selection affect the evolution of inversions. A key difference between inversions and other mutations, such as single nucleotide variants, is that the fitness of an inversion may be affected by a larger number of frequently interacting processes. This considerably complicates the analysis of the causes underlying the evolution of inversions. We discuss the extent to which these mechanisms can be disentangled, and by which approach.
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  • Result 1-4 of 4
Type of publication
journal article (3)
research review (1)
Type of content
peer-reviewed (3)
other academic/artistic (1)
Author/Editor
Johansson, Lars (1)
Boucher, Olivier (1)
Sulo, Gerhard (1)
Abbott, Jessica K. (1)
Hassankhani, Hadi (1)
Liu, Yang (1)
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Ali, Muhammad (1)
Mitchell, Philip B (1)
McKee, Martin (1)
Madotto, Fabiana (1)
Abolhassani, Hassan (1)
Rezaei, Nima (1)
Castro, Franz (1)
Koul, Parvaiz A. (1)
Ciais, Philippe (1)
Weiss, Daniel J. (1)
Ackerman, Ilana N. (1)
Brenner, Hermann (1)
Ferrara, Giannina (1)
Salama, Joseph S. (1)
Mullany, Erin C. (1)
Abbafati, Cristiana (1)
Bensenor, Isabela M. (1)
Bernabe, Eduardo (1)
Carrero, Juan J. (1)
Cercy, Kelly M. (1)
Zaki, Maysaa El Saye ... (1)
Esteghamati, Alireza (1)
Esteghamati, Sadaf (1)
Fanzo, Jessica (1)
Farzadfar, Farshad (1)
Foigt, Nataliya A. (1)
Grosso, Giuseppe (1)
Islami, Farhad (1)
James, Spencer L. (1)
Khader, Yousef Saleh (1)
Kimokoti, Ruth W. (1)
Kumar, G. Anil (1)
Lallukka, Tea (1)
Lotufo, Paulo A. (1)
Mendoza, Walter (1)
Nagel, Gabriele (1)
Nguyen, Cuong Tat (1)
Nixon, Molly R. (1)
Ong, Kanyin L. (1)
Pereira, David M. (1)
Rivera, Juan A. (1)
Sanchez-Pimienta, Ta ... (1)
Shin, Min-Jeong (1)
Thrift, Amanda G. (1)
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University
University of Gothenburg (1)
Uppsala University (1)
Stockholm University (1)
Chalmers University of Technology (1)
Karolinska Institutet (1)
Högskolan Dalarna (1)
Language
English (4)
Research subject (UKÄ/SCB)
Natural sciences (3)
Medical and Health Sciences (1)

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