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Search: WFRF:(Seitz Miriam) > (2013)

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1.
  • Hammer, Stephan C., et al. (author)
  • Squalene hopene cyclases : highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation
  • 2013
  • In: Current opinion in chemical biology. - : Elsevier. - 1367-5931 .- 1879-0402. ; 17:2, s. 293-300
  • Journal article (peer-reviewed)abstract
    • A review. We review here how the inherent promiscuous nature, as well as the evolvability of terpene cyclase enzymes enables new applications in chem. We mainly focus on squalene hopene cyclases, class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. We highlight recent findings to demonstrate that these enzymes are capable of activating different functionalities other than the traditional terminal isoprene CC-group as well as being compatible with a wide range of nucleophiles beyond the 'ene-functionality'. Thus, squalene hopene cyclases demonstrate a great potential to be used as a toolbox for general Bronsted acid catalysis.
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2.
  • Seitz, Miriam, et al. (author)
  • Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene-Hopene Cyclases
  • 2013
  • In: ChemBioChem. - : Wiley-VCH Verlag GmbH & Co. KGaA. - 1439-4227 .- 1439-7633. ; 14:Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved., s. 436-439
  • Journal article (peer-reviewed)abstract
    • Promiscuous enzymes: The substrate promiscuity of squalene–hopene cyclases has been explored and applied in the enzyme‐catalyzed synthesis of heterocyclic terpenoids. Features of this work include cyclization reactions without pyrophosphate activation, and stereospecific ring closure of substrates of varying chain length and terminal nucleophile. This provides a biocatalytic alternative to traditional chemical catalysts.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Syrén, Per-Olof (2)
Hauer, Bernhard (2)
Seitz, Miriam (2)
Nestl, Bettina M. (2)
Hammer, Stephan C. (1)
Steiner, Lisa (1)
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Klebensberger, Janos ... (1)
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University
Royal Institute of Technology (2)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (2)
Year
2013 (2)Undo refine

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