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1.	Brueggemann, AB, et al. (author) Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data 2021 In: The Lancet. Digital health. - : Elsevier. - 2589-7500. ; 3:6, s. E360-E370 Journal article (peer-reviewed)
2.	Jiang, M., et al. (author) The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication 2021 In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:27 Journal article (peer-reviewed)abstract We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required both for gene expression and for generating the RNA primers needed for initiation of mtDNA synthesis. In the absence of mtSSB, transcription from LSP is strongly up-regulated, but no replication primers are formed. Using deep sequencing in a mouse knockout model and biochemical reconstitution experiments with pure proteins, we find that mtSSB is necessary to restrict transcription initiation to optimize RNA primer formation at both origins of mtDNA replication. Last, we show that human pathological versions of mtSSB causing severe mitochondrial disease cannot efficiently support primer formation and initiation of mtDNA replication. © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Li, X. (1); Corcoran, M. (1); Zhou, F. (1); Roberts, M. (1); Meehan, M. (1); Shaw, D (1); show more...; Jiang, M. (1); Roberts, R. (1); Ip, M (1); Henriques-Normark, B (1); Davies, H (1); Morgan, J (1); Perry, M. (1); Falkenberg, Maria, 1 ... (1); Zhu, Xuefeng (1); Hoffmann, S (1); Molling, P (1); Atanassov, I (1); Johnston, J. (1); Cao, B. (1); Vogel, U. (1); Jacobsson, S (1); Jacobsson, Susanne, ... (1); Lindholm, L (1); Kristinsson, KG (1); Gustafsson, Claes M, ... (1); Macao, Bertil, 1969 (1); Carelli, V (1); Smith, AJ (1); Murphy, J (1); Szilagyi, Zsolt (1); von Gottberg, A (1); Xie, Xie (1); Milenkovic, D. (1); Larsson, N. G. (1); Cottrell, S (1); Hilty, M (1); Hoberg, Emily, 1986 (1); Morfeldt, E. (1); Tandukar, N. (1); Coelho, J (1); Martin, I (1); Brueggemann, AB (1); van Rensburg, MJJ (1); McCarthy, ND (1); Jolley, KA (1); Maiden, MCJ (1); Mölling, Paula, 1971 ... (1); Amin-Chowdhury, Z (1); Bennett, DE (1); show less...

University: Karolinska Institutet (2); University of Gothenburg (1); Örebro University (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2021 (2)Undo refine

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