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Träfflista för sökning "WFRF:(Tong G. L.) srt2:(2000-2004)"

Search: WFRF:(Tong G. L.) > (2000-2004)

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  • Bjork, P, et al. (author)
  • A novel conserved RNA-binding domain protein, RBD-1, is essential for ribosome biogenesis
  • 2002
  • In: Molecular biology of the cell. - : American Society for Cell Biology (ASCB). - 1059-1524 .- 1939-4586. ; 13:10, s. 3683-3695
  • Journal article (peer-reviewed)abstract
    • Synthesis of the ribosomal subunits from pre-rRNA requires a large number of trans-acting proteins and small nucleolar ribonucleoprotein particles to execute base modifications, RNA cleavages, and structural rearrangements. We have characterized a novel protein, RNA-binding domain-1 (RBD-1), that is involved in ribosome biogenesis. This protein contains six consensus RNA-binding domains and is conserved as to sequence, domain organization, and cellular location from yeast to human. RBD-1 is essential in Caenorhabditis elegans. In the dipteran Chironomus tentans, RBD-1 (Ct-RBD-1) binds pre-rRNA in vitro and anti-Ct-RBD-1 antibodies repress pre-rRNA processing in vivo. Ct-RBD-1 is mainly located in the nucleolus in an RNA polymerase I transcription-dependent manner, but it is also present in discrete foci in the interchromatin and in the cytoplasm. In cytoplasmic extracts, 20–30% of Ct-RBD-1 is associated with ribosomes and, preferentially, with the 40S ribosomal subunit. Our data suggest that RBD-1 plays a role in structurally coordinating pre-rRNA during ribosome biogenesis and that this function is conserved in all eukaryotes.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Tong, YG (2)
Zhang, X. (1)
Hokfelt, T (1)
HELLMAN, U (1)
Wang, HF (1)
Lu, YJ (1)
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Burglin, TR (1)
Wieslander, L (1)
Bao, L (1)
Jin, SX (1)
Cai, HJ (1)
Grant, G (1)
Bauren, G (1)
Bjork, P (1)
Jin, SB (1)
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University
Karolinska Institutet (2)
Language
English (2)
Year
2002 (2)

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