| 1. |
- Heidbuchel, Hein, et al.
(author)
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Author reply : To PMID 23625942
- 2014
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In: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 16:1, s. 151-152
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Journal article (peer-reviewed)
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| 2. |
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| 3. |
- Heidbuchel, Hein, et al.
(author)
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EHRA Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation : executive summary
- 2013
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In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:27, s. 2094-2106
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Journal article (peer-reviewed)abstract
- New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in specific clinical situations. This text is an executive summary of a practical guide that the European Heart Rhythm Association (EHRA) has assembled to help physicians in the use of the different NOACs. The full text is being published in EP Europace. Practical answers have been formulated for 15 concrete clinical scenarios: (i) practical start-up and follow-up scheme for patients on NOACs; (ii) how to measure the anticoagulant effect of NOACs; (iii) drug-drug interactions and pharmacokinetics of NOACs; (iv) switching between anticoagulant regimens; (v) ensuring compliance of NOAC intake; (vi) how to deal with dosing errors; (vii) patients with chronic kidney disease; (viii) what to do if there is a (suspected) overdose without bleeding, or a clotting test is indicating a risk of bleeding?; (ix) management of bleeding complications; (x) patients undergoing a planned surgical intervention or ablation; (xi) patients undergoing an urgent surgical intervention; (xii) patients with AF and coronary artery disease; (xiii) cardioversion in a NOAC-treated patient; (xiv) patients presenting with acute stroke while on NOACs; (xv) NOACs vs. VKAs in AF patients with a malignancy. Since new information is becoming available at a rapid pace, an EHRA web site with the latest updated information accompanies the guide (www.NOACforAF.eu). It also contains links to the ESC AF Guidelines, a key message pocket booklet, print-ready files for a proposed universal NOAC anticoagulation card, and feedback possibilities.
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| 4. |
- Heidbuchel, Hein, et al.
(author)
-
European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
- 2013
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In: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 15:5, s. 625-651
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Journal article (peer-reviewed)abstract
- New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in clinical practice. Many unresolved questions on how to optimally use these drugs in specific clinical situations remain. The European Heart Rhythm Association set out to coordinate a unified way of informing physicians on the use of the different NOACs. A writing group listed 15 topics of concrete clinical scenarios and formulated as practical answers as possible based on available evidence. The 15 topics are: (1) Practical start-up and follow-up scheme for patients on NOACs; (2) How to measure the anticoagulant effect of NOACs; (3) Drugdrug interactions and pharmacokinetics of NOACs; (4) Switching between anticoagulant regimens; (5) Ensuring compliance of NOAC intake; (6) How to deal with dosing errors; (7) Patients with chronic kidney disease; (8) What to do if there is a (suspected) overdose without bleeding, or a clotting test is indicating a risk of bleeding? (9) Management of bleeding complications; (10) Patients undergoing a planned surgical intervention or ablation; (11) Patients undergoing an urgent surgical intervention; (12) Patients with AF and coronary artery disease; (13) Cardioversion in a NOAC-treated patient; (14) Patients presenting with acute stroke while on NOACs; (15) NOACs vs. VKAs in AF patients with a malignancy. Since new information is becoming available at a rapid pace, an EHRA Web site with the latest updated information accompanies this text (www.NOACforAF.eu).
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| 5. |
- Bauersachs, Rupert, et al.
(author)
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Oral rivaroxaban for symptomatic venous thromboembolism.
- 2010
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In: The New England journal of medicine. - 1533-4406. ; 363:26, s. 2499-510
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Journal article (peer-reviewed)abstract
- Rivaroxaban, an oral factor Xa inhibitor, may provide a simple, fixed-dose regimen for treating acute deep-vein thrombosis (DVT) and for continued treatment, without the need for laboratory monitoring.
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| 6. |
- Gu, Yu-Mei, et al.
(author)
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Outcome-Driven Thresholds for Ambulatory Pulse Pressure in 9938 Participants Recruited From 11 Populations
- 2014
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In: Hypertension. - 0194-911X .- 1524-4563. ; 63:2, s. 229-237
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Journal article (peer-reviewed)abstract
- Evidence-based thresholds for risk stratification based on pulse pressure (PP) are currently unavailable. To derive outcome-driven thresholds for the 24-hour ambulatory PP, we analyzed 9938 participants randomly recruited from 11 populations (47.3% women). After age stratification (<60 versus >= 60 years) and using average risk as reference, we computed multivariable-adjusted hazard ratios (IIRs) to assess risk by tenths of the PP distribution or risk associated with stepwise increasing (+1 mm Hg) PP levels. All adjustments included mean arterial pressure. Among 6028 younger participants (68 853 person-years), the risk of cardiovascular (HR, 1.58; P=0.011) or cardiac (HR, 1.52; P=0.056) events increased only in the top PP tenth (mean, 60.6 mm Hg). Using stepwise increasing PP levels, the lower boundary of the 95% confidence interval of the successive thresholds did not cross unity. Among 3910 older participants (39 923 person-years), risk increased (P <= 0.028) in the top PP tenth (mean, 76.1 mm Hg). HRs were 1.30 and 1.62 for total and cardiovascular mortality, and 1.52, 1.69, and 1.40 for all cardiovascular, cardiac, and cerebrovascular events. The lower boundary of the 95% confidence interval of the HRs associated with stepwise increasing PP levels crossed unity at 64 mm Hg. While accounting for all covariables, the top tenth of PP contributed less than 0.3% (generalized R-2 statistic) to the overall risk among the elderly. Thus, in randomly recruited people, ambulatory PP does not add to risk stratification below age 60; in the elderly, PP is a weak risk factor with levels below 64 mm Hg probably being innocuous.
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| 7. |
- Hayes, Matthew, et al.
(author)
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THE LYMAN ALPHA REFERENCE SAMPLE : EXTENDED LYMAN ALPHA HALOS PRODUCED AT LOW DUST CONTENT
- 2013
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In: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 765:2, s. L27-
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Journal article (peer-reviewed)abstract
- We report on new imaging observations of the Lyman alpha emission line (Ly alpha), performed with the Hubble Space Telescope, that comprise the backbone of the Lyman alpha Reference Sample. We present images of 14 starburst galaxies at redshifts 0.028 < z < 0.18 in continuum-subtracted Ly alpha, H alpha, and the far ultraviolet continuum. We show that Ly alpha is emitted on scales that systematically exceed those of the massive stellar population and recombination nebulae: as measured by the Petrosian 20% radius, RP20, Ly alpha radii are larger than those of H alpha by factors ranging from 1 to 3.6, with an average of 2.4. The average ratio of Ly alpha-to-FUV radii is 2.9. This suggests that much of the Ly alpha light is pushed to large radii by resonance scattering. Defining the Relative Petrosian Extension of Ly alpha compared to H alpha, xi(Ly alpha) = R-P20(Ly alpha)/R-P20(H alpha), we find xi(Ly alpha) to be uncorrelated with total Ly alpha luminosity. However, xi(Ly alpha) is strongly correlated with quantities that scale with dust content, in the sense that a low dust abundance is a necessary requirement (although not the only one) in order to spread Ly alpha photons throughout the interstellar medium and drive a large extended Ly alpha halo.
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| 8. |
- Hayes, Matthew, et al.
(author)
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THE LYMAN ALPHA REFERENCE SAMPLE. II. HUBBLE SPACE TELESCOPE IMAGING RESULTS, INTEGRATED PROPERTIES, AND TRENDS
- 2014
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In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 782:1
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Journal article (peer-reviewed)abstract
- We report new results regarding the Ly alpha output of galaxies, derived from the Lyman Alpha Reference Sample, and focused on Hubble Space Telescope imaging. For 14 galaxies we present intensity images in Ly alpha, H alpha, and UV, and maps of H alpha/H beta, Ly alpha equivalent width (EW), and Ly alpha/H alpha. We present Ly alpha and UV radial light profiles and show they are well-fitted by Sersic profiles, but Ly alpha profiles show indices systematically lower than those of the UV (n approximate to 1-2 instead of greater than or similar to 4). This reveals a general lack of the central concentration in Ly alpha that is ubiquitous in the UV. Photometric growth curves increase more slowly for Ly alpha than the far ultraviolet, showing that small apertures may underestimate the EW. For most galaxies, however, flux and EW curves flatten by radii approximate to 10 kpc, suggesting that if placed at high-z only a few of our galaxies would suffer from large flux losses. We compute global properties of the sample in large apertures, and show total Ly alpha luminosities to be independent of all other quantities. Normalized Ly alpha throughput, however, shows significant correlations: escape is found to be higher in galaxies of lower star formation rate, dust content, mass, and nebular quantities that suggest harder ionizing continuum and lower metallicity. Six galaxies would be selected as high-z Ly alpha emitters, based upon their luminosity and EW. We discuss the results in the context of high-z Ly alpha and UV samples. A few galaxies have EWs above 50 angstrom, and one shows f(esc)(Ly alpha) of 80%; such objects have not previously been reported at low-z.
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| 9. |
- Loth, Daan W, et al.
(author)
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Genome-wide association analysis identifies six new loci associated with forced vital capacity
- 2014
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46, s. 669-677
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Journal article (peer-reviewed)abstract
- Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
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| 10. |
- Pardy, Stephen A., et al.
(author)
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THE LYMAN ALPHA REFERENCE SAMPLE. III. PROPERTIES OF THE NEUTRAL ISM FROM GBT AND VLA OBSERVATIONS
- 2014
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In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 794:2
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Journal article (peer-reviewed)abstract
- We present new Hi imaging and spectroscopy of the 14 UV-selected star-forming galaxies in the Lyman Alpha Reference Sample (LARS), aimed for a detailed study of the processes governing the production, propagation, and escape of Ly alpha photons. New Hi spectroscopy, obtained with the 100 m Green Bank Telescope (GBT), robustly detects the Hi spectral line in 11 of the 14 observed LARS galaxies (although the profiles of two of the galaxies are likely confused by other sources within the GBT beam); the three highest redshift galaxies are not detected at our current sensitivity limits. The GBT profiles are used to derive fundamental Hi line properties of the LARS galaxies. We also present new pilot Hi spectral line imaging of five of the LARS galaxies obtained with the Karl G. Jansky Very Large Array (VLA). This imaging localizes the Hi gas and provides a measurement of the total Hi mass in each galaxy. In one system, LARS 03 (UGC 8335 or Arp 238), VLA observations reveal an enormous tidal structure that extends over 160 kpc from the main interacting systems and that contains >10(9) M-circle dot of Hi. We compare various Hi properties with global Ly alpha quantities derived from Hubble Space Telescope measurements. The measurements of the Ly alpha escape fraction are coupled with the new direct measurements of Hi mass and significantly disturbed Hi velocities. Our robustly detected sample reveals tentative correlations between the total Hi mass and linewidth, and key Ly alpha tracers. Further, on global scales, these data support a complex coupling between Ly alpha propagation and the Hi properties of the surrounding medium.
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| 11. |
- Peetermans, Marijke, et al.
(author)
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Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections.
- 2014
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In: BMC microbiology. - : Springer Science and Business Media LLC. - 1471-2180. ; 14:1
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Journal article (peer-reviewed)abstract
- Background Staphylococcus aureus (S. aureus) is a frequent cause of skin and soft tissue infections. A unique feature of S. aureus is the combined presence of coagulases that trigger fibrin formation and of the plasminogen activator staphylokinase (SAK). Whereas the importance of fibrin generation for S. aureus virulence has been established, the role of SAK remains unclear.We studied the role of plasminogen activation by SAK in a skin infection model in mice and evaluated the impact of alpha-2-antiplasmin (¿2AP) deficiency on the spreading and proteolytic activity of S. aureus skin infections. The species-selectivity of SAK was overcome by adenoviral expression of human plasminogen. Bacterial spread and density was assessed non-invasively by imaging the bioluminescence of S. aureus Xen36.ResultsSAK-mediated plasmin activity increased the local invasiveness of S. aureus, leading to larger lesions with skin disruption as well as decreased bacterial clearance by the host. Even though fibrin and bacterial surfaces protected SAK-mediated plasmin activity from inhibition by ¿2AP, the deficiency of ¿2AP resulted in increased bacterial spreading. SAK-mediated plasmin also induced secondary activation of gelatinases, shown both in vitro and in lesions from the in vivo model.ConclusionSAK contributes to the phenotype of S. aureus skin infections by enhancing bacterial spreading as a result of fibrinolytic and proteolytic activation.
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| 12. |
- Östlin, Göran, et al.
(author)
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THE Ly alpha REFERENCE SAMPLE. I. SURVEY OUTLINE AND FIRST RESULTS FOR MARKARIAN 259
- 2014
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In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 797:1
-
Journal article (peer-reviewed)abstract
- The Ly alpha Reference Sample (LARS) is a substantial program with the Hubble Space Telescope (HST) that provides a sample of local universe laboratory galaxies in which to study the detailed astrophysics of the visibility and strength of the Ly alpha line of neutral hydrogen. Ly alpha is the dominant spectral line in use for characterizing high-redshift (z) galaxies. This paper presents an overview of the survey, its selection function, and HST imaging observations. The sample was selected from the combined GALEX+Sloan Digital Sky Survey catalog at z = 0.028-0.19, in order to allow Ly alpha to be captured with combinations of long-pass filters in the Solar Blind Channel (SBC) of the Advanced Camera for Surveys (ACS) onboard HST. In addition, LARS utilizes H alpha and H beta narrowband and u, b, i broadband imaging with ACS and the Wide Field Camera 3 (WFC3). In order to study galaxies in which large numbers of Ly alpha photons are produced (whether or not they escape), we demanded an H alpha equivalent width W(H alpha) >= 100 angstrom. The final sample of 14 galaxies covers far-UV (FUV, lambda similar to 1500 angstrom) luminosities that overlap with those of high-z Ly alpha emitters (LAEs) and Lyman break galaxies (LBGs), making LARS a valid comparison sample. We present the reduction steps used to obtain the Ly alpha images, including our LARS eXtraction software (LaXs), which utilizes pixel-by-pixel spectral synthesis fitting of the energy distribution to determine and subtract the continuum at Ly alpha. We demonstrate that the use of SBC long-pass-filter combinations increase the signal-to-noise ratio by an order of magnitude compared to the nominal Ly alpha filter available in SBC. To exemplify the science potential of LARS, we also present some first results for a single galaxy, Mrk 259 (LARS #1). This irregular galaxy shows bright and extended (indicative of resonance scattering) but strongly asymmetric Ly alpha emission. Spectroscopy from the Cosmic Origins Spectrograph on board HST centered on the brightest UV knot shows a moderate outflow in the neutral interstellar medium (probed by low ionization stage absorption features) and Ly alpha emission with an asymmetric profile. Radiative transfer modeling is able to reproduce the essential features of the Ly alpha line profile and confirms the presence of an outflow. From the integrated photometry we measure an Ly alpha luminosity of L-Ly alpha= 1.3x10(42) erg s(-1) an equivalent width W(Ly alpha) = 45 angstrom and an FUV absolute magnitude M-FUV = -19.2 (AB). Mrk 259 would hence be detectable in high-z Ly alpha and LBG surveys. The total Ly alpha escape fraction is 12%. This number is higher than the low-z average, but similar to that at z > 4, demonstrating that LARS provides a valid comparison sample for high-z galaxy studies.
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