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- Holgersson, Georg, et al.
(author)
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The prognostic value of pre-treatment thrombocytosis in two cohorts of patients with non-small cell lung cancer treated with curatively intended chemoradiotherapy
- 2017
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In: Neoplasma (Bratislava). - Bratislava : AEPress. - 0028-2685 .- 1338-4317. ; 64:6, s. 909-915
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Journal article (peer-reviewed)abstract
- Chemoradiotherapy is the standard of care for inoperable stage III non-small cell lung cancer (NSCLC). This treatment, however, offers only a small chance of cure and is associated with many side effects. Little research has been made concerning which patients benefit most/least from the treatment. The present study evaluates the prognostic value of anemia, leukocytosis and thrombocytosis at diagnosis in this treatment setting. In the present study, data were collected retrospectively for 222 patients from two different phase II studies conducted between 2002-2007 in Sweden with patients treated with chemoradiotherapy for stage IIIA-IIIB NSCLC. Clinical data and the serum values of hemoglobin (Hgb), White blood cells (WBC) and Platelets (Plt) at enrollment were collected for all patients and studied in relation to overall survival using Kaplan-Meier product-limit estimates and a multivariate Cox proportional hazards regression model. The results showed that patients with thrombocytosis (Plt > 350 x 109 /L) had a shorter median overall survival (14.5 months) than patients with normal Plt at baseline (23.7 months). Patients with leukocytosis (WBC > 9 x 109 /L) had a shorter median survival (14.9 months) than patients with a normal WBC at baseline (22.5 months). However, in a multivariate model including all lab parameters and clinical factors, only thrombocytosis and performance status displayed a prognostic significance. In Conclusion, thrombocytosis showed to be an independent prognostic marker associated with shorter overall survival in stage III NSCLC treated with curatively intended chemoradiotherapy. This knowledge can potentially be used together with established prognostic factors, such as performance status when choosing the optimal therapy for the individual patient in this clinical setting
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| 3. |
- Willén-Lundgren, Berit, 1970-, et al.
(author)
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Värderelationell reflektion med stöd av digital spegling
- 2017
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In: Utbildning och Lärande / Education and Learning. - Skövde : Högskolan i Skövde. - 2001-4554. ; 11:1, s. 34-46
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Journal article (peer-reviewed)abstract
- This study presents a development project within pre-school teacher training at Linnaeus University with the purpose to enhance student activity, goal fulfilment and the use of digital media. Empirical data is from an assessment where students were filmed in two steps, the second time by themselves, reflecting on a previously filmed presentation. Student previous knowledge is used as a capacity for self-reflection elaborating meta-cognitive awareness for a future teaching practice. The study uses a relational approach which takes into account both cognitive and emotional aspects of learning. Analyses show an enhanced meta-cognitive awareness of future pedagogical practice manifested at three levels. Students’ strategies vary between being able to act upon established knowledge in a pedagogical practice to be- ing able to stretch into and vision a future practice and discuss consequences for relations and the impact of democratic values in practice. Digital reflections as a didactical tool were by students themselves regarded as supportive for qualitative variations of reflections related to a future professional practice although further precision in task description and framing is probably necessary for a majority to develop an elaborated awareness.
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