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Träfflista för sökning "WFRF:(Yamashita Y.) srt2:(2015-2019)"

Search: WFRF:(Yamashita Y.) > (2015-2019)

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  • 2017
  • swepub:Mat__t
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  • Nango, E., et al. (author)
  • A three-dimensional movie of structural changes in bacteriorhodopsin
  • 2016
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 354:6319, s. 1552-1557
  • Journal article (peer-reviewed)abstract
    • Bacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron laser to visualize conformational changes in bR from nanoseconds to milliseconds following photoactivation. An initially twisted retinal chromophore displaces a conserved tryptophan residue of transmembrane helix F on the cytoplasmic side of the protein while dislodging a key water molecule on the extracellular side. The resulting cascade of structural changes throughout the protein shows how motions are choreographed as bR transports protons uphill against a transmembrane concentration gradient.
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  • Iiyoshi, A., et al. (author)
  • Muon catalyzed fusion, present and future
  • 2019
  • In: Proceedings of the international conference on advances and applications in plasma physics (aapp 2019). - : American Institute of Physics (AIP). - 9780735419261
  • Conference paper (peer-reviewed)abstract
    • The novel proposal of the Muon Catalyzed Fusion (MCF) concept is brought to light employing recent results on its relevant cross sections. In 1993, Kino et al. proposed an innovative scheme of MCF, employing non-adiabatic calculations of muonic atom-nucleus collision in the energy range from 10-3 eV to 100 eV, whereby the fusion in flight along with the formation of muonic molecular resonances was revisited [1]. In 1994, Froelich independently calculated the cross section up to 2 keV, and found the behavior of like resonance [2]. In 1996, Kino et al. examined these resonances, and concluded that the resonances were not suitable for MCF [3]. As a result, the research has been continued to examine the possibility of non-resonant In-flight Muon Catalyzed Fusion (IFMCF) calculating the muonic atom-nucleus collision cross-section with an improved precision within the optical model for nuclear reactions. The resultant fusion cross section was 2000 barns at 1.4 keV [4] which should be good enough to be used as a fast neutron source [5]. A research program has been initiated to confirm these results theoretically as well as experimentally. For the sake of the theoretical analysis, a few-body computer code has been put forward to handle the nuclear reactions for nucleon transfer. In this paper, an innovative compact reactor concept is proposed, based on IFMCF. In this concept, muons are injected to a gas target of D2 and T2, which is pressurized aerodynamically by the Mach shock wave using a supersonic stream generated in a Laval nozzle [6], [7]. It generates the output power of 28 MW with 1019 cm-3s-1 of fusions by supplying fresh muons of 1016 cm-3s-1 providing 1000 times of catalyzed cycle of reactions. To maintain Q values > 1, assuming 30% efficiency for thermal to electric conversion, the energy supply for muon production can be as low as 8 GeV/muons. One of the possible applications of muon catalyzed fusion is transmutation of long-lived fission products (LLFPs).
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  • van Erp, Susan, et al. (author)
  • Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
  • 2015
  • In: Developmental Cell. - : Elsevier BV. - 1534-5807 .- 1878-1551. ; 35:5, s. 537-552
  • Journal article (peer-reviewed)abstract
    • Many guidance receptors are proteolytically cleaved by membrane-associated metalloproteases of the ADAM family, leading to the shedding of their ectodomains. Ectodomain shedding is crucial for receptor signaling and function, but how this process is controlled in neurons remains poorly understood. Here, we show that the transmembrane protein Lrig2 negatively regulates ADAM-mediated guidance receptor proteolysis in neurons. Lrig2 binds Neogenin, a receptor for repulsive guidance molecules (RGMs), and prevents premature Neogenin shedding by ADAM17 (TACE). RGMa reduces Lrig2-Neogenin interactions, providing ADAM17 access to Neogenin and allowing this protease to induce ectodomain shedding. Regulation of ADAM17-mediated Neogenin cleavage by Lrig2 is required for neurite growth inhibition by RGMa in vitro and for cortical neuron migration in vivo. Furthermore, knockdown of Lrig2 significantly improves CNS axon regeneration. Together, our data identify a unique ligand-gated mechanism to control receptor shedding by ADAMs and reveal functions for Lrigs in neuron migration and regenerative failure.
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  • Result 1-13 of 13

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