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1.	Campbell, TL, et al. (author) Investigating neonatal health risk variables through cell-type specific methylome-wide association studies 2024 In: Clinical epigenetics. - 1868-7083. ; 16:1, s. 69- Journal article (peer-reviewed)
2.	Chan, RF, et al. (author) Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case-Control Differences 2020 In: Schizophrenia bulletin. - : Oxford University Press (OUP). - 1745-1701 .- 0586-7614. ; 46:2, s. 319-327 Journal article (peer-reviewed)
3.	Guintivano, J, et al. (author) Test-statistic inflation in methylome-wide association studies 2020 In: Epigenetics. - : Informa UK Limited. - 1559-2308 .- 1559-2294. ; 15:11, s. 1163-1166 Journal article (peer-reviewed)
4.	Guintivano, J, et al. (author) Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance 2022 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 27:6, s. 2858-2867 Journal article (peer-reviewed)abstract Postpartum depression (PPD) affects 1 in 7 women and has negative mental health consequences for both mother and child. However, the precise biological mechanisms behind the disorder are unknown. Therefore, we performed the largest transcriptome-wide association study (TWAS) for PPD (482 cases, 859 controls) to date using RNA-sequencing in whole blood and deconvoluted cell types. No transcriptional changes were observed in whole blood. B-cells showed a majority of transcriptome-wide significant results (891 transcripts representing 789 genes) with pathway analyses implicating altered B-cell activation and insulin resistance. Integration of other data types revealed cell type-specific DNA methylation loci and disease-associated eQTLs (deQTLs), but not hormones/neuropeptides (estradiol, progesterone, oxytocin, BDNF), serve as regulators for part of the transcriptional differences between cases and controls. Further, deQTLs were enriched for several brain region-specific eQTLs, but no overlap with MDD risk loci was observed. Altogether, our results constitute a convergence of evidence for pathways most affected in PPD with data across different biological mechanisms.
5.	van den Oord, EJCG, et al. (author) Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples 2023 In: Molecular psychiatry. - 1476-5578. Journal article (peer-reviewed)
6.	van den Oord, EJCG, et al. (author) Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples 2023 In: Molecular psychiatry. - 1476-5578. ; 28:75, s. 2088-2094 Journal article (peer-reviewed)

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Result 1-6 of 6

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Aberg, KA (6); van den Oord, EJCG (6); Hultman, CM (4); Xie, LY (3); Campbell, TL (3); Sullivan, PF (2); show more...; Mors, O (2); Zhao, M. (2); Turecki, G. (2); Dean, B (2); Meltzer-Brody, S (2); Guintivano, J (2); Chan, RF (2); Shabalin, AA (2); Rubinow, DR (2); Staunstrup, NH (2); Clark, SL (1); Mill, J (1); Feinberg, AP (1); Fallin, MD (1); Kahler, AK (1); Johnson, RH (1); Montano, C (1); Hannon, E (1); Kähler, AK (1); show less...

University: Karolinska Institutet (6)

Language: English (6)

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