| 1. |
- Björnsson Hallgren, Hanna C, et al.
(author)
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Specific exercises for subacromial pain : Good results maintained for 5 years
- 2017
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In: Acta Orthopaedica. - : Taylor & Francis. - 1745-3674 .- 1745-3682. ; 88:6, s. 600-605
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Journal article (peer-reviewed)abstract
- Background and purpose — We have previously shown that specific exercises reduced the need for surgery in subacromial painpatients at 1-year follow-up. We have now investigated whetherthis result was maintained after 5 years and compared the outcomesof surgery and non-surgical treatment.Patients and methods — 97 patients were included in the previouslyreported randomized study of patients on a waiting list forsurgery. These patients were randomized to specifi c or unspecifi cexercises. After 3 months of exercises the patients were asked ifthey still wanted surgery and this was also assessed at the present5-year follow-up. The 1-year assessment included Constant–Murley score, DASH, VAS at night, rest and activity, EQ-5D, andEQ-VAS. All these outcome assessments were repeated after 5years in 91 of the patients.Results — At the 5-year follow-up more patients in the specifi cexercise group had declined surgery, 33 of 47 as compared with16 of 44 (p = 0.001) in the unspecifi c exercise group. The meanConstant–Murley score continued to improve between the 1- and5-year follow-ups in both surgically and non-surgically treatedgroups. On a group level there was no clinically relevant changebetween 1 and 5 years in any of the other outcome measuresregardless of treatment.Interpretation — This 5-year follow-up of a previously publishedrandomized controlled trial found that specifi c exercisesreduced the need for surgery in patients with subacromial pain.Patients not responding to specifi c exercises may achieve similargood results with surgery. These fi ndings emphasize that a specifi cexercise program may serve as a selection tool for surgery.
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| 2. |
- Bränning, Camilla, et al.
(author)
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Counterworking Male Takeover during Class Room Activities in Superior Technical Education
- 2005
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In: [Host publication title missing].
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Conference paper (peer-reviewed)abstract
- An increase in student activity is the goal of various pedagogic approaches and highly valued in most teaching situations. The benefits of student activation are widely discussed in literature (Fox, 1983), but possible drawbacks of such techniques need to be identified and compensations need to be found. This paper discusses a case study concerning one particular course moment, a seminar, held over a two-year period in a program with a strong underrepresentation of female students. The study shows how changes in the pedagogic approach can lead to an increased student activity, although accompanied by a total male takeover of the class room activity. It seems like traditional social structures tend to take over the class room activities, determining the roles that different gender groups may play (Parker, 1996; Olevard, 1997). At the same time, seminars are an important factor in the socialization of students, affecting the following cultural and structural development in the academia. “Hence, besides the content of the course, students attending seminars learn social structures as well, determining who may or may not speak” (Gunnarsson, 1995). The tools presented in this paper are applicable in any LTH classroom and also in future work places. To counterwork male takeover, without suppressing the overall student activity, is the topic of this paper. Different pedagogic measures are analyzed in this context and discussed in the paper.
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| 3. |
- Eftring, Håkan, et al.
(author)
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Tips for creating inclusive classrooms at LTH
- 2023
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In: LTH:s 12:e Pedagogiska inspirationskonferens. - 2003-3761 .- 2003-377X. ; , s. 45-47
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Conference paper (other academic/artistic)abstract
- All people are different. All teachers are different. All students are different. They have different life situations, different study situations, and different preferences, conditions, and abilities. How can we take this diversity into account when we plan our teaching and exams? What situations should we prepare for? How can we help students focus on their learning and not on unnecessary obstacles we unconsciously introduce? If we make small efforts upfront, this lets us avoid much larger efforts later on when we are confronted with the reality of students in our class and their different needs.At this round table, let us discuss diversity in teaching and learning. During fall 2023, a pilot of the course “The Inclusive Classroom” was run at LTH, the Faculty of Engineering at Lund University. We present the compiled, most important take-aways of participants and instructors, in addition to individual case-studies. In a nutshell: There are a lot of easy things you can do that can already have large effects, and you are not alone: LTH has many resources to support you. Please join a supportive, engaged community and learn from and with us!
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| 4. |
- Franzén, Frida, et al.
(author)
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Förstudie om beställarnätverk för cement, betong och alternativ
- 2024
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Reports (other academic/artistic)abstract
- Den här förstudien syftade till att undersöka behoven av ett beställarnätverk förcement, betong och alternativ, samt hur ett sådant skulle kunna organiserats. Idagfinns klimatförbättrad betong på marknaden, men efterfrågan är svag. Ett beställarnätverk kan tänkas höja kompetensen hos beställarna för att ställa högre klimatkrav i upphandling av betong.Förstudien har utgått från ett antal frågeställningar och använt en intervjustudie som den centrala delen i informationsinhämtningen. En för projektet sammansatt expertgrupp har stöttat förstudien med kunskap inom relaterade branscher och sakfrågor såsom offentlig upphandling, beställarnätverk, bygg- och anläggningsbranschen samt betongbranschen. För urval av informanter utfördes en schematisk bild av leverantörs- och beställarled för cement, betong och alternativ. Den visar på en komplex väv av aktörer som på olika sätt påverkar hela värdekedjan. Vem som kan ses som ”beställare” i relation till upphandling av cement, betong och alternativ i denna väv är inte helt enkelt. Förstudien valde att inte hantera beställare av cement, då detta är betongleverantörer/producenter. Studien fokuserar således på beställare av betong, och till viss del alternativ (alternativa material till betong). Även med denna avgränsning är det potentiella antalet beställare som skulle kunna vara tilltänkta för ett beställarnätverk stort, varför förstudiens resultat behöver beaktas i det hänseendet och med den osäkerhet det innebär framför allt gällande beställares behov av ett beställarnätverk.I förstudien genomfördes 14 intervjuer med offentliga beställare, myndigheter, privata beställare, samt akademi och innovationsprogram. Beställarna var överlag positiva till bildandet av ett beställarnätverk. De flesta har idag utmaningar med att ta till sig ny kunskap då utvecklingen i betongbranschen går snabbt, att förstå upphandlingstekniska aspekter såsom kravställning på klimatförbättrad betong, samt hur man kan räkna och följa upp klimataspekter i byggprojekt. De övriga informanterna var till viss del tveksamma till att ett beställarnätverk är den rätta lösningen för att förflytta branschen och skapa större efterfrågan för klimatförbättrad betong. Dock ansåg samtliga informanter att det krävs ett stortkunskapslyft, i samtliga led i beställarledet, från planerare till projektör.Angående organisering ansåg de offentliga beställarna (kommuner) samt expertgruppen att det bör vara ett beställarnätverk endast för offentliga beställare, på grund av de särskilda förutsättningar som dessa har. De flesta ansåg inte att ett beställarnätverk behöver delas upp på byggsektor respektive anläggningssektor, men att det finns en utmaning med att få frågorna i nätverket relevanta för samtligaaktörer. Vidare ansåg de flesta att ett beställarnätverk behöver vara finansierat och styrt av en eller flera myndigheter. Då krävs det dock ett tydligt regeringsuppdrag, med öronmärkt finansiering för detta samordningsuppdrag.Många informanter menar att det krävs initiativ och samordning för att täppa kunskapsluckan som finns i beställarled, med den kunskap som finns genom aktuella forsknings- och innovationssatsningar samt befintliga vägledningar. Här menade de flesta att det dock inte handlar om ett beställarnätverk, utan snarare om att bygga på de nätverk och andra konstellationer för samverkan som redan finns och facilitera kunskapsspridning i olika branscher.Förstudien presenterar avslutningsvis ett antal rekommendationer för fortsatt arbete, som kan delas upp i två huvudsakliga spår: ett spår gällande fortsatt utredning för ett offentligt beställarnätverk eller liknande, och ett spår för fortsatt utredning kring en nationell plattform som samlar fler aktörer. Här nedan följer rekommendationerna i korthet:Som en miniminivå rekommenderar förstudien att det görs en vidare analysi hur offentliga beställare helst tar del av ny information och stöd om upphandling av betong och alternativ med mindre klimatpåverkan.Som en maximinivå rekommenderar förstudien att det görs utredningar kring möjligheter att ge ett regeringsuppdrag till en myndighet att etableraett forum för samverkan kring klimatförbättrad betong och alternativ.Utred hur det arbete som Upphandlingsmyndigheten gör, kring upphandlingsstöd av klimatförbättrad betong bäst förvaltas för genomslag hos beställare.Involvera branschorganisationer för att nå stora delar av branscherna och privata beställare.Bygg på det som finns! Med detta avses kunskap och erfarenheter i berörda branscher samt befintliga samverkansinitiativ, dock inte på befintliga beställarnätverk.
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| 5. |
- Frimodt-Møller, Niels, et al.
(author)
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Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
- 2024
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In: International Journal of Antimicrobial Agents. - : Elsevier. - 0924-8579 .- 1872-7913. ; 64:1
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Journal article (peer-reviewed)abstract
- BackgroundThe aminoglycoside apramycin has been proposed as a drug candidate for the treatment of critical Gram-negative systemic infections. However, the potential of apramycin in the treatment of drug-resistant bloodstream infections (BSIs) has not yet been assessed.MethodsThe resistance gene annotations of 40 888 blood-culture isolates were analysed. In vitro profiling of apramycin comprised cell-free translation assays, broth microdilution, and frequency of resistance determination. The efficacy of apramycin was studied in a mouse peritonitis model for a total of nine Escherichia coli and Klebsiella pneumoniae isolates.ResultsGenotypic aminoglycoside resistance was identified in 87.8% of all 6973 carbapenem-resistant Enterobacterales blood-culture isolates, colistin resistance was shown in 46.4% and apramycin in 2.1%. Apramycin activity against methylated ribosomes was > 100-fold higher than that for other aminoglycosides. Frequencies of resistance were < 10-9 at 8 × minimum inhibitory concentration (MIC). Tentative epidemiological cut-offs (TECOFFs) were determined as 8 µg/mL for E. coli and 4 µg/mL for K. pneumoniae. A single dose of 5 to 13 mg/kg resulted in a 1-log colony-forming unit (CFU) reduction in the blood and peritoneum. Two doses of 80 mg/kg resulted in an exposure that resembles the AUC observed for a single 30 mg/kg dose in humans and led to complete eradication of carbapenem- and aminoglycoside-resistant bacteraemia.ConclusionEncouraging coverage and potent in vivo efficacy against a selection of highly drug-resistant Enterobacterales isolates in the mouse peritonitis model warrants the conduct of clinical studies to validate apramycin as a drug candidate for the prophylaxis and treatment of BSI.
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| 6. |
- Granlund, Alexander, et al.
(author)
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Evaluation of Local Conditions and Their Impact on Bifacial PV Performance at High Latitude
- 2022
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Conference paper (peer-reviewed)abstract
- Different conditions such as module orientation, ground albedo, shading and latitude are known to affect the performance of bifacial photovoltaic modules. We evaluate bifacial performance for one year at a site located at 65°N through comparison of measured and simulated front and back side plane-of-array irradiation. Each investigated module has a different azimuth, tilt, and exposure to shading from the surroundings. Local shading is found to severely impact the energy yield of the site in general, and individual modules to a varying degree depending on their location and orientation. Proper shading analysis appears to be required in the planning phase of a bifacial photovoltaic installation to accurately calculate the expected energy yield. The bifacial gain of the modules with azimuths in the east–west sector is found to span a range from 16 % to approximately the bifaciality factor, depending on the orientation. To fully utilize the potential of bifacial photovoltaics, this variability also needs to be carefully considered when planning and building bifacial photovoltaic installations.
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| 7. |
- Granlund, Alexander, et al.
(author)
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Evaluation of Snow Removal Methods for Rooftop Photovoltaics
- 2022
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Conference paper (peer-reviewed)abstract
- Avoiding snow on photovoltaic (PV) installations is motivated for two reasons: to decrease power losses from shading, or to decrease mechanical loads to avoid damage to the PV-installation and the underlying construction. We experimentally investigated the effectiveness and suitability of four different snow removal methods at our facility in the north of Sweden (Piteå, 65°N), throughout three winters. The layout of a PV installation and the underlying roof, together with meteorological conditions and snow characteristics, impact which methods are best suited for snow removal. A simple roof rake with a rectangular toolhead works well when the snowpack is compact and not too thick, whereas a roof rake with a slide works better when the snow is dry and packed. Neither the investigated passive hydrophobic surface coatings, nor the active forward bias electrical heating methods induced shedding of the accumulated snowpack in our experiments without additional intervention. At our test facility in Piteå, the roof rake with a slide was the most effective and user-friendly snow removal. Despite maximum snow loads of approximately 1 kPa, far below the modules’ rating, cell damage was observed for both snow removal groups (except for the slide roof rake group) and the control group.
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| 8. |
- Granlund, Alexander, et al.
(author)
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The Influence of Module Tilt on Snow Shadowing of Frameless Bifacial Modules
- 2019
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Conference paper (other academic/artistic)abstract
- In this study, frameless bifacial modules’ performance in a boreal climate is examined, with a focus on snow coverage and snow clearance for different module tilt angles. A group of ten bifacial modules at different tilt angles located in northern Sweden at latitude 65°N were studied during the first months of 2019. It was shown that modules mounted at 0 and 15° tilt was covered the most by snow and 80 and 90° the least. All other modules, mounted at 25-70° tilt, showed mostly similar results in snow coverage and removal. All modules were subjected to snow coverage from January to March. In January no considerable energy output was observed for any module. In February and March modules with tilt angles of 0 and 15° had a lower energy output than the other modules, for which no considerable differences were observed. In April, when no snow coverage occurred, the module mounted at 45° had the largest energy output and in May, 25-35° performed the best. For the entire period of January-May the modules at 35-45° output the most energy.
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| 9. |
- Juhas, Mario, et al.
(author)
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In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii
- 2019
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In: Journal of Antimicrobial Chemotherapy. - : OXFORD UNIV PRESS. - 0305-7453 .- 1460-2091. ; 74:4, s. 944-952
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Journal article (peer-reviewed)abstract
- Objectives: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii, and provides a rationale for its superior antibacterial activity in the presence of aminoglycoside resistance determinants.Methods: A thorough antibacterial assessment of apramycin with 1232 clinical isolates from Europe, Asia, Africa and South America was performed by standard CLSI broth microdilution testing. WGS and susceptibility testing with an engineered panel of aminoglycoside resistance-conferring determinants were used to provide a mechanistic rationale for the breadth of apramycin activity.Results: MIC distributions and MIC90 values demonstrated broad antibacterial activity of apramycin against Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Morganella morganii, Citrobacter freundii, Providencia spp., Proteus mirabilis, Serratia marcescens and A. baumannii. Genotypic analysis revealed the variety of aminoglycoside-modifying enzymes and rRNA methyltransferases that rendered a remarkable proportion of clinical isolates resistant to standard-of-care aminoglycosides, but not to apramycin. Screening a panel of engineered strains each with a single well-defined resistance mechanism further demonstrated a lack of cross-resistance to gentamicin, amikacin, tobramycin and plazomicin.Conclusions: Its superior breadth of activity renders apramycin a promising drug candidate for the treatment of systemic Gram-negative infections that are resistant to treatment with other aminoglycoside antibiotics.
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| 10. |
- Klamberg, Mark, et al.
(author)
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FRA-lagen medför massiv kartläggning av oskyldiga
- 2008. - 12
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Other publication (pop. science, debate, etc.)abstract
- Mark Klamberg Doktorand juridik, Stockholms universitet, Mikael Nilsson Doktorand datalogi, Kungliga Tekniska högskolan, Anna Petersson Doktorand matematik, Uppsala universitet, Peter Seipel Professor emeritus rättsinformatik, Stockholms universitet, Janne Flyghed Professor kriminologi, Stockholms universitet, Cecilia Magnusson Sjöberg Professor i rättsinformatik, Stockholms universitet, Jussi Karlgren Docent språkteknologi, Swedish Institute of Computer Science, Markus Bylund Doktor i data- och systemvetenskap inriktning personlig integritet, Swedish Institute of Computer Science, Karl Palmås Civilingenjör och doktor i sociologi, Handelshögskolan vid Göteborgs universitet, Christopher Kullenberg Doktorand vetenskapsteori, Göteborgs universitet, Pär Ström Civilingenjör och författare, integritetsombudsman på tankesmedjan Den nya välfärden, Daniel Thorburn Professor i statistik, Stockholms universitet, Johan Westerholm Kapten, reservofficerare underrättelsetjänst, rådgivare Greycat
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