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Träfflista för sökning "WFRF:(Wiklund H.) "

Search: WFRF:(Wiklund H.)

  • Result 1-10 of 383
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  • Jiang, X., et al. (author)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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  • Speliotes, Elizabeth K., et al. (author)
  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
  • 2010
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
  • Journal article (peer-reviewed)abstract
    • Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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  • Went, M, et al. (author)
  • Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
  • 2019
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 213-
  • Journal article (peer-reviewed)abstract
    • The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this Article, the order of authors within the author list was incorrect. The PRACTICAL consortium was incorrectly listed after Richard S. Houlston and should have been listed after Nora Pashayan. This error has been corrected in the HTML version of the Article; the PDF version was correct at the time of publication.
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  • Gusev, A, et al. (author)
  • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
  • 2016
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
  • Journal article (peer-reviewed)abstract
    • Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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  • Result 1-10 of 383
Type of publication
journal article (326)
conference paper (44)
book chapter (5)
reports (3)
other publication (2)
review (2)
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research review (1)
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Type of content
peer-reviewed (320)
other academic/artistic (62)
pop. science, debate, etc. (1)
Author/Editor
Wiklund, F (105)
Gronberg, H (94)
Wiklund, P (54)
Kote-Jarai, Z (49)
Schleutker, J (48)
Muir, K (45)
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Maier, C (44)
Brenner, H (43)
Travis, RC (43)
Haiman, CA (42)
Stanford, JL (42)
Batra, J (42)
Cybulski, C (41)
Al Olama, AA (40)
Teixeira, MR (40)
Nordestgaard, BG (39)
Kibel, AS (39)
Kaneva, R (39)
Giles, GG (37)
Pashayan, N (36)
Cannon-Albright, L (35)
Eeles, RA (35)
Berndt, SI (34)
Khaw, KT (34)
Benlloch, S (32)
Aly, M (32)
Thibodeau, SN (32)
Albanes, D (31)
Hamdy, FC (31)
Xu, JF (30)
Pandha, H (30)
Easton, DF (29)
Kraft, P (29)
Hunter, DJ (28)
Henderson, BE (27)
John, EM (26)
Le Marchand, L (25)
Lindstrom, S (25)
Ingles, SA (24)
Schumacher, FR (22)
Wiklund, Urban (20)
Conti, DV (20)
Isaacs, WB (20)
SCHAID, DJ (19)
Chanock, SJ (19)
Kogevinas, M (19)
Key, TJ (19)
McDonnell, SK (19)
Stevens, VL (19)
Penney, KL (19)
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University
Karolinska Institutet (234)
Uppsala University (73)
Umeå University (54)
University of Gothenburg (41)
Lund University (19)
University of Borås (15)
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Linköping University (14)
Mälardalen University (8)
Luleå University of Technology (6)
Royal Institute of Technology (5)
University of Gävle (4)
Karlstad University (4)
Högskolan Dalarna (4)
RISE (3)
Stockholm University (2)
Örebro University (2)
Jönköping University (2)
Mid Sweden University (2)
Södertörn University (1)
Chalmers University of Technology (1)
The Swedish School of Sport and Health Sciences (1)
Linnaeus University (1)
Marie Cederschiöld högskola (1)
Swedish University of Agricultural Sciences (1)
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Language
English (377)
Swedish (4)
Danish (1)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (100)
Natural sciences (23)
Social Sciences (9)
Engineering and Technology (7)
Agricultural Sciences (2)
Humanities (2)

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