| 111. |
- Arabi, C. Mas, et al.
(author)
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Localized structures formed through domain wall locking in cavity-enhanced second-harmonic generation
- 2020
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In: Optics Letters. - : OPTICAL SOC AMER. - 0146-9592 .- 1539-4794. ; 45:20, s. 5856-5859
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Journal article (peer-reviewed)abstract
- We analyze the formation of localized structures in cavity-enhanced second-harmonic generation. We focus on the phase-matched limit, and consider that fundamental and generated waves have opposite signs of group velocity dispersion. We show that these states form due to the locking of domain walls connecting two stable homogeneous states of the system, and undergo collapsed snaking. We study the impact of temporal walk-off on the stability and dynamics of these localized states. (C) 2020 Optical Society of America
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| 112. |
- Arpanaei, F., et al.
(author)
-
Hyperaccelerated Power Optimization in Multi-Band Elastic Optical Networks
- 2024
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In: 2024 Optical Fiber Communications Conference and Exhibition, OFC 2024 - Proceedings.
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Conference paper (peer-reviewed)abstract
- We show that solving interrelated inverse differential equations can address pre-tilt power optimization, resulting in a few-second-computed optimal power for each span and boosting average channel generalized signal-to-the-noise ratio (GSNR) by up to 0.5 dB.
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| 113. |
- Beal, Jacob, et al.
(author)
-
Robust estimation of bacterial cell count from optical density
- 2020
-
In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
-
Journal article (peer-reviewed)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 114. |
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| 115. |
- Benítez, G. E. F., et al.
(author)
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Smartphone application for quantitative measurement of Parkinson tremors
- 2015
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In: IFMBE Proceedings. - Cham : Springer. - 9783319131160 ; , s. 785-788
-
Conference paper (peer-reviewed)abstract
- One of the most common concerns in the atten-tion of patients with Parkinson's disease is an objectively eval-uation of the illness progress and the efficacy of treatments, in terms of the intensity and frequency of tremors. This symptom is produced by gradual degradation of the pigmented neurons located at the substantia nigra in the brain, in order to detect such movement levels. This paper proposes a Smartphone application for a quantitative detection, measurement and analysis of the Parkinson's tremor, due to the global use of Smartphones and the affordable cost of some Android plat-form devices. The subjects of this working project are those people who suffer from Parkinson's disease, who could down-load the application to their mobile phone in order to measure quantitatively the intensity and duration of their tremors, in any place, to send reports by email or to record them for a later use. The application enables the remote monitoring of the patients.
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| 116. |
- Bergues, B., et al.
(author)
-
Nonlinear interaction of 100-eV attosecond XUV-pulses with core electrons in Xenon
- 2018
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In: Optics InfoBase Conference Papers. - : Optica Publishing Group. - 9781557528209
-
Conference paper (peer-reviewed)abstract
- We demonstrate multiphoton ionization of inner-shell electrons in Xenon with 100-eV attosecond pulses. This was achieved with a novel XUV source based on high-harmonic generation in the gas phase driven with multi-TW few-cycle laser pulses.
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| 117. |
- Bergues, B., et al.
(author)
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Tabletop nonlinear optics in the 100-eV spectral region
- 2018
-
In: Optica. - : Optical Society of America. - 2334-2536. ; 5:3, s. 237-242
-
Journal article (peer-reviewed)abstract
- Nonlinear light-matter interactions in the extreme ultraviolet (XUV) are a prerequisite to perform XUV-pump/XUV-probe spectroscopy of core electrons. Such interactions are now routinely investigated at free-electron laser (FEL) facilities. Yet, electron dynamics are often too fast to be captured with the femtosecond resolution of state-of-the-art FELs. Attosecond pulses from laser-driven XUV-sources offer the necessary temporal resolution. However, intense attosecond pulses supporting nonlinear processes have only been available for photon energy below 50 eV, precluding XUV-pump/XUV-probe investigation of typical inner-shell processes. Here, we surpass this limitation by demonstrating two-photon absorption from inner electronic shells of xenon at photon energies around 93 eV and 115 eV. This advance opens the door for attosecond real-time observation of nonlinear electron dynamics deep inside atoms.
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| 118. |
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| 119. |
- Chatzikonstantinou, T, et al.
(author)
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COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study
- 2021
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35:12, s. 3444-3454
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Journal article (peer-reviewed)abstract
- Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
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| 120. |
- Dahl, R., et al.
(author)
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Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis
- 2006
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In: J Allergy Clin Immunol.. ; 118:2
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Journal article (peer-reviewed)abstract
- BACKGROUND: Allergen immunotherapy (desensitization) by injection is effective for seasonal allergic rhinitis and has been shown to induce long-term disease remission. The sublingual route also has potential, although definitive evidence from large randomized controlled trials has been lacking. OBJECTIVE: The aim was to confirm the efficacy of a rapidly dissolving grass allergen tablet (GRAZAX, ALK-Abello, Horsholm, Denmark) compared with placebo in patients with seasonal rhinoconjunctivitis. METHODS: A longitudinal, double-blind, placebo-controlled, parallel-group study that included 51 centers from 8 countries. Subjects were randomized (1:1) to receive a grass allergen tablet or placebo once daily. A total of 634 subjects with a history of grass pollen-induced rhinoconjunctivitis for at least 2 years and confirmation of IgE sensitivity (positive skin prick test and serum-specific IgE) were included in the study. Subjects commenced treatment at least 16 weeks before the grass pollen season, and treatment was continued throughout the entire season. RESULTS: The primary efficacy analysis showed a reduction of 30% in rhinoconjunctivitis symptom score (P < .0001) and a reduction of 38% in rhinoconjunctivitis medication score (P < .0001) compared with placebo. Side effects mainly comprised mild itching and swelling in the mouth that was in general well tolerated and led to treatment withdrawal in less than 4% of participants. There were no serious local side effects and no severe systemic adverse events. CONCLUSION: Sublingual immunotherapy with grass allergen tablets was effective in grass pollen-induced rhinoconjunctivitis. The tablet was well tolerated with minor local side effects. CLINICAL IMPLICATIONS: The grass allergen tablet represents a safe alternative to injection immunotherapy suitable for home use.
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