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61.	Arnau-Soler, A, et al. (author) Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland 2019 In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 14- Journal article (peer-reviewed)abstract Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10−6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PIWIL4; p = 4.95 × 10−9; total SLE) and rs17070072 (intronic to ZCCHC2; p = 1.46 × 10−8; dependent SLE). A third locus upstream CYLC2 (rs12000047 and rs12005200, p < 2.00 × 10−8; dependent SLE) when the joint effect of the SNP main and GxE effects was considered. GWEIS gene-based tests identified: MTNR1B with GxE effect with dependent SLE in Generation Scotland; and PHF2 with the joint effect in UK Biobank (p < 2.77 × 10−6). Polygenic risk scores (PRSs) analyses incorporating GxE effects improved the prediction of depressive symptom scores, when using weights derived from either the UK Biobank GWAS of depressive symptoms (p = 0.01) or the PGC GWAS of major depressive disorder (p = 5.91 × 10−3). Using an independent sample, PRS derived using GWEIS GxE effects provided evidence of shared aetiologies between depressive symptoms and schizotypal personality, heart disease and COPD. Further such studies are required and may result in improved treatments for depression and other stress-related conditions.
62.	Coleman, JRI, et al. (author) Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank 2020 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 25:7, s. 1430-1446 Journal article (peer-reviewed)
63.	Glanville, KP, et al. (author) Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression 2020 In: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 87:5, s. 419-430 Journal article (peer-reviewed)
64.	Jostins, L, et al. (author) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease 2012 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 491:7422, s. 119-124 Journal article (peer-reviewed)
65.	Manchia, M, et al. (author) Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report 2013 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 8:6, s. e65636- Journal article (peer-reviewed)
66.	Marshall, CR, et al. (author) Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:1, s. 27-35 Journal article (peer-reviewed)
67.	Ou, AH, et al. (author) Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study 2024 In: Translational psychiatry. - 2158-3188. ; 14:1, s. 109- Journal article (peer-reviewed)
68.	Schubert, KO, et al. (author) Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients 2022 In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1, s. 278- Journal article (other academic/artistic)
69.	Wray, NR, et al. (author) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression 2018 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 50:5, s. 668- Journal article (peer-reviewed)
70.	Aprile, E., et al. (author) Constraining the Spin-Dependent WIMP-Nucleon Cross Sections with XENON1T 2019 In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 122:14 Journal article (peer-reviewed)abstract We report the first experimental results on spin-dependent elastic weakly interacting massive particle (WIMP) nucleon scattering from the XENON1T dark matter search experiment. The analysis uses the full ton year exposure of XENON1T to constrain the spin-dependent proton-only and neutron-only cases. No significant signal excess is observed, and a profile likelihood ratio analysis is used to set exclusion limits on the WIMP-nucleon interactions. This includes the most stringent constraint to date on the WIMP-neutron cross section, with a minimum of 6.3 x 10(-42) cm(2) at 30 GeV/c(2) and 90% confidence level. The results are compared with those from collider searches and used to exclude new parameter space in an isoscalar theory with an axial-vector mediator.

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Result 61-70 of 184

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Type of publication: journal article (170); conference paper (11); other publication (2); research review (1)

Type of content: peer-reviewed (163); other academic/artistic (21)

Author/Editor: Cichon, S (113); Rietschel, M (78); Nothen, MM (65); Mattheisen, M (47); Degenhardt, F (43); Schulze, TG (43); show more...; Ripke, S (42); Brown, A. (40); Budnik, R. (40); Cichon, D. (40); Landsman, H. (40); Muller-Myhsok, B (40); Colijn, A. P. (39); Agostini, F. (39); Aprile, E. (39); Arneodo, F. (39); Baudis, L. (39); Bruno, G. (39); Decowski, M. P. (39); Fulgione, W. (39); Di Giovanni, A. (39); Galloway, M. (39); Lang, R. F. (39); Lindemann, S. (39); Lopes, J. A. M. (39); Masbou, J. (39); Molinario, A. (39); Murra, M. (39); Plante, G. (39); Rupp, N. (39); Dos Santos, J. M. F. (39); Sartorelli, G. (39); Schumann, M. (39); Selvi, M. (39); Shagin, P. (39); Thers, D. (39); Wei, Y. (39); Weinheimer, C. (39); Bruenner, S. (38); Alfonsi, M. (38); Cardoso, J. M. R. (38); Cussonneau, J. P. (38); Di Gangi, P. (38); Lindner, M. (38); Messina, M. (38); Oberlack, U. (38); Schreiner, J. (38); Pienaar, J. (38); Breen, G (38); Werge, T (38); show less...

University: Karolinska Institutet (133); Stockholm University (42); University of Gothenburg (39); Umeå University (24); Uppsala University (11); Lund University (8); show more...; Örebro University (3); Stockholm School of Economics (1); show less...

Language: English (184)

Research subject (UKÄ/SCB): Medical and Health Sciences (56); Natural sciences (55); Social Sciences (1)

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