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11.	Khatri, C, et al. (author) Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study 2021 In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830- Journal article (peer-reviewed)abstract Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
12.	2021 swepub:Mat__t
13.	Kanai, M, et al. (author) 2023 swepub:Mat__t
14.	Ahmad, T, et al. (author) Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries 2016 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 117:5, s. 601- Journal article (peer-reviewed)
15.	Ahmad, T, et al. (author) In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study 2017 In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. - : Elsevier BV. - 1532-2157 .- 0748-7983. ; 43:12, s. 2324-2332 Journal article (peer-reviewed)
16.	Ahmad, T, et al. (author) Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery 2017 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 119:2, s. 258-266 Journal article (peer-reviewed)
17.	Shrine, N, et al. (author) Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk 2023 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 55:3, s. 410- Journal article (peer-reviewed)abstract Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
18.	Abbafati, C, et al. (author) Five insights from the Global Burden of Disease Study 2019 2020 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 396:10258, s. 1135-1159 Journal article (peer-reviewed)
19.	2019 Journal article (peer-reviewed)
20.	Murray, CJL, et al. (author) Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 2020 In: Lancet (London, England). - : Elsevier BV. - 1474-547X .- 0140-6736. ; 396:10258, s. 1223-1249 Journal article (peer-reviewed)

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Type of publication: journal article (168); conference paper (4)

Type of content: peer-reviewed (161); other academic/artistic (12)

Author/Editor: Hall, P (53); Easton, DF (47); Brenner, H (46); Chang-Claude, J (44); Czene, K (43); Giles, GG (43); show more...; Fasching, PA (43); Hopper, JL (42); Southey, MC (42); Dunning, AM (42); Cox, A (42); Wang, Q. (41); Schmidt, MK (41); Beckmann, MW (41); Couch, FJ (41); Nevanlinna, H (41); Dork, T (41); Burwinkel, B (40); Mannermaa, A (40); Bolla, MK (39); Brauch, H (39); Hamann, U (39); Garcia-Closas, M (39); Bojesen, SE (38); Pharoah, PDP (38); Dennis, J (37); Lindblom, A (37); Margolin, S (37); Andrulis, IL (37); Lubinski, J (37); Benitez, J. (36); Milne, RL (36); Michailidou, K (36); Lambrechts, D (36); Haiman, CA (36); Chenevix-Trench, G (36); Borresen-Dale, AL (36); Anton-Culver, H (35); Devilee, P (35); Blomqvist, C (33); Guenel, P (33); Kosma, VM (33); Winqvist, R (33); Meindl, A (33); Tomlinson, I (32); Jakubowska, A (32); Truong, T (30); Arndt, V (30); Simard, J (30); Figueroa, J (30); show less...

University: Karolinska Institutet (141); Lund University (50); Uppsala University (41); Umeå University (13); University of Gothenburg (11); Stockholm University (8); show more...; Royal Institute of Technology (7); Högskolan Dalarna (7); Mid Sweden University (5); Linköping University (4); Chalmers University of Technology (4); Kristianstad University College (2); Jönköping University (2); Halmstad University (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (182)

Research subject (UKÄ/SCB): Medical and Health Sciences (65); Natural sciences (26); Engineering and Technology (2); Social Sciences (2)

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