| 1. |
- Abrahamsson, Annelie, et al.
(author)
-
Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo
- 2016
-
In: Oncoimmunology. - : TAYLOR & FRANCIS INC. - 2162-4011 .- 2162-402X. ; 5:10
-
Journal article (peer-reviewed)abstract
- Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment.Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes. On the MRI, lean tissue fraction (LTF) was calculated for a continuous measurement of breast density. LTF confirmed the selection from the mammograms and gave a continuous measurement of breast density. Microdialysis revealed significantly increased extracellular in vivo levels of IL-6, IL-8, vascular endothelial growth factor, and CCL5 in dense breast tissue as compared with nondense breasts. Moreover, the ratio IL-1Ra/IL-1 was decreased in dense breasts. No differences were found in levels of IL-1, IL-1Ra, CCL2, leptin, adiponectin, or leptin:adiponectin ratio between the two breast tissue types. Significant positive correlations between LTF and the pro-inflammatory cytokines as well as between the cytokines were detected. Stainings of the core biopsies exhibited increased levels of immune cells in dense breast tissue.Our data show that dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment and, if confirmed in a larger cohort, suggests novel targets for prevention therapies for women with dense breast tissue.
|
|
| 2. |
|
|
| 3. |
- Andersson, T, et al.
(author)
-
Community-based prevention of perinatal deaths : lessons from nineteenth-century Sweden.
- 2000
-
In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 29:3, s. 542-8
-
Journal article (peer-reviewed)abstract
- Poor reproductive history, particularly previously high perinatal mortality, is associated with high perinatal mortality. Midwifery-assisted at home deliveries successfully reduced perinatal mortality.
|
|
| 4. |
- Andersson, Tommy, et al.
(author)
-
Seeking No War, Achieving No Peace: The Conflict over the Siachen Glacier
- 2018
-
Other publication (other academic/artistic)abstract
- This paper models “no war, no peace” situations in a game theoretical framework where two countries are engaged in a standoff over a military sector. The first main objective is to identify rational grounds for such situations and, more precisely, explicit equilibria that leads to such situations. It is demonstrated that both countries get the same payoff from being in this continuous state of perpetual hostility and, moreover, that “no war, no peace” situations can be explained only if the countries perceive an equal measure of military advantage by controlling the area. Given this insight, the second objective of the paper is to provide insights about how “no war, no peace” situations can be resolved. Two different pathways are suggested. The first is idealistic and based on mutual trust whereas the second is based on deterrence meaning that both countries impose a threat of using armed force against the other country in their respective military doctrines.
|
|
| 5. |
- Borg, Åke
(author)
-
Hereditary prostate cancer: a new piece of the puzzle.
- 2001
-
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 7:2, s. 153-155
-
Journal article (peer-reviewed)abstract
- An eagerly awaited prostate cancer susceptibility gene has been announced. But does the candidate live up to expectations?
|
|
| 6. |
- Borg, Åke, et al.
(author)
-
Predicting the future of breast cancer.
- 2003
-
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 9:1, s. 16-18
-
Journal article (peer-reviewed)
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Dahlqvist, Johan, 1987-, et al.
(author)
-
TEST TURBINE INSTRUMENTATION FOR CAVITY PURGE INVESTIGATIONS
- 2014
-
In: The XXII Symposium on Measuring Techniques in Turbomachinery, Lyon, 4-5 September 2014.
-
Conference paper (other academic/artistic)abstract
- The upstream wheelspace of the KTH Test Turbine has been instrumented with the aim of investigating cavity flow phenomena, as well as cavity-main annulus interaction. Measurements include static pressure, unsteady pressure and temperature.The stage used is of high pressure steam turbine design. The trials include investigating the design point and also a high pressure, high speed operating point, assimilating gas turbine operation. At each point, varying amounts of purge flow are superposed and the influences on the measurements studied.Initial results show considerable dependence of both operating
|
|
| 10. |
- Dahlqvist Jönsson, Patrik, 1974, et al.
(author)
-
Outcomes of an educational intervention for the family of a person with bipolar disorder : a 2-year follow-up study
- 2011
-
In: Journal of Psychiatric and Mental Health Nursing. - Chichester : Wiley. - 1351-0126 .- 1365-2850. ; 18:4, s. 333-341
-
Journal article (peer-reviewed)abstract
- This study aimed to analyse the outcomes of an educational intervention for family members living with a person with bipolar disorder. A longitudinal study was conducted comprising a 10-session educational intervention designed for families with members in outpatient mental health care. Thirty-four family members agreed to participate. Data were collected on five occasions, at baseline and during a 2-year follow-up through self-assessment instruments: the Carers of Older People in Europe Index, the Jalowiec Coping Scale-40, the Sense of Coherence questionnaire and the Social Adaptation Self-evaluation Scale. The results showed that the condition had a considerable negative impact on the family members as carers, but the educational intervention increased their understanding, which facilitated the management of their lives. A significant improvement in stress management was seen over time and social functioning was retained. The study showed that families living with one member with bipolar disorder benefited from the educational intervention in terms of increasing understanding of the condition and reducing stress. Mental health care needs to develop educational interventions further and offer the families support to strengthen their ability to manage with the situation.
|
|
