| 1. |
- Bartoletti, Stefania, et al.
(author)
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Introduction and fundamentals
- 2024
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In: Positioning and Location-based Analytics in 5G and Beyond. - 9781119911463 ; , s. 1-18
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Book chapter (other academic/artistic)abstract
- This chapter introduces the book and presents the main principles and fundamentals for positioning and location-based analytics, thus effectively providing the basis for the following chapters. After a brief introduction and motivation for the book, we present the main use cases, verticals, and applications for positioning and location-based analytics. Then, we provide the technical fundamentals for understanding positioning and navigation algorithms, as well as location-based analytics. An introduction to the architectural principles is presented. Finally, an outline of the book chapters is provided.
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| 2. |
- Bartoletti, Stefania, et al.
(author)
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Positioning methods
- 2024
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In: Positioning and Location-based Analytics in 5G and Beyond. - 9781119911463 ; , s. 21-50
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Book chapter (other academic/artistic)abstract
- This chapter introduces the main positioning methods, starting from the state-of-the-art and following a statistical estimation perspective. This is followed by an in-depth treatment of radio positioning, first focusing on device-based positioning and then on device-free positioning. Finally, recent approaches based on artificial intelligence methods for positioning are detailed.
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| 3. |
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| 4. |
- Birke, Robert, et al.
(author)
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Self-aware computing systems : Open challenges and future research directions
- 2017
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In: Self-Aware Computing Systems. - Cham : Springer International Publishing. - 9783319474748 - 9783319474724 ; , s. 709-722
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Book chapter (peer-reviewed)abstract
- In this chapter, we discuss the open challenges in building self-aware computing systems that are still being faced by the research and development community. The challenges can be theoretical, technical, computational, or even sociological. First, we highlight the challenges associated with each of the earlier parts of the book and summarize on respective future research directions. We then offer concluding remarks and an outlook into the future in the last section.
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| 5. |
- Edsjö, Joakim, et al.
(author)
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WIMP searches with AMANDA-B10
- 2001
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In: The Identification Of Dark Matter. - : World Scientific. - 9789810246020 ; , s. 499-505
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Book chapter (other academic/artistic)
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| 6. |
- Feng, Y., et al.
(author)
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Acupuncture in polycystic ovary syndrome: Potential and challenge
- 2013
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In: Current Research in Acupuncture. - New York, NY : Springer New York. - 9781461433576 ; , s. 487-515
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Book chapter (peer-reviewed)abstract
- Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder affecting 5-10 % of women of reproductive age. Conventional pharmacological therapy and surgery are effective but with obvious side effects and limited long-term treatment. Therefore, acupuncture therapy, as a complement or alternative to conventional therapies, may be an alternative for women with PCOS by reducing their symptoms. Experimental, mechanistic trials clearly indicate positive effects of acupuncture on reproductive and metabolic function. However, lack of randomized controlled trials hinders the translation and application of acupuncture in the treatment of PCOS. In this chapter, we summarize the PCOS diagnostic criteria and characters, PCOS-like animal models as well as the possible physiological basis and mechanism of the effect of acupuncture in PCOS. Clinical data from studies in women with PCOS and experimental observations in PCOS-like rat models suggest that acupuncture exerts long-lasting beneficial effects on metabolic, endocrine, and neuroendocrine systems. © 2013 Springer Science+Business Media New York. All rights are reserved.
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| 7. |
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| 8. |
- Guerova, G., et al.
(author)
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National Status Reports
- 2020
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In: Advanced GNSS Tropospheric Products for Monitoring Severe Weather Events and Climate. - Cham : Springer International Publishing. - 9783030139001 ; , s. 403-481
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Book chapter (other academic/artistic)abstract
- In this section a summary of the national progress reports is given. GNSS4SWEC Management Committee (MC) members provided outline of the work conducted in their countries combining input from different partners involved. In the COST Action paticipated member from 32 COST countries, 1 Near Neighbour Country and 8 Intrantional Partners from Australia, Canada, Hong Kong and USA. The text reflects the state as of 1 January 2018.
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| 9. |
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| 10. |
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| 11. |
- Megido, Loerto, et al.
(author)
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Understanding and utilizing the biomolecule/nanosystems interface: Soft materials and coatings for controlled drug release
- 2017
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In: Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture. - 9780323480642 ; , s. 244-260
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Book chapter (other academic/artistic)abstract
- Combining biomolecules with materials used in medicine allows for local control of the biological response and can be used for modulating the host immune response, a major challenge in the efficacy of many medical devices. In Subchapter 3.1, we will review different methods used to attach biomolecules to materials, focusing on protein conjugation methods. We will begin by describing noncovalent immobilization strategies, including encapsulation within biomaterials and adsorption to material surfaces. We will then discuss strategies to covalently attach biomolecules to materials via the use of specific functional groups, thus enhancing the stability of the interaction. Finally, we will describe emerging methods to site specifically immobilize biomolecules to materials such that proteins are presented in an oriented manner, improving their overall functionality. Throughout the subchapter, we will emphasize the advantages and disadvantages of each technique, successes achieved, as well as the challenges remaining in this growing field.During last years, increasing development of nanoparticles as targeted drug delivery agents, has led to a wide amount of studies involving their characterization to the application as novel therapeutic agents. Hence, the nanoparticles interact with biological environments when they enter in the human body, and then proteins bind to the nanomaterial surface forming the protein corona. Protein corona has a great relevance in the interaction and function of the nanoparticle-drug conjugates. In fact, its characterization is one of the main challenges for nanoscience development. Herein, it is reviewed the main proteomic methods described for quantify and qualify the protein corona formed around nanoparticles to better understand the process of interaction with the biological media, and to decipher key parameters to control the effects of the protein corona.In Subchapter 3.3, the structure and working principles of coatings for controlled drug release in oral drug administration are presented. The release mechanisms, including diffusion, dissolution, osmotic pumping, and swelling are described. The soft materials used in the majority of controlled drug release formulations are natural and synthetic polymers. They are presented here and examples of specific polymers applied in controlled release formulations are provided. There is also a section containing characterization of soft materials using in situ electron microscopy for studying water transport through coatings at high-spatial resolution. The reason for this is that the detailed properties and release mechanisms of the controlled release depend on the material nanostructure. The in situ characterization gives access not only the information about the nanostructure but also the direct correlation between structure and properties on different length scales. Finally, an overview of the present major challenges and future possibilities concerning controlled drug release formulations is presented.Targeting cancer cells with functional nanoprobes possessing a targeting drug unit and an imaging moiety carries great potential for early detection, accurate diagnosis, and targeted therapy of various diseases. Given their nanoscopic dimensions, ultrasmall particles ( < 100nm) are in general well suited for interactions with the cells; however, the current challenge of the nanomedicine is to transform inorganic nanoparticles of metals (e.g., gold) or metal oxide (e.g., magnetite) into signal-generating vectors. Engineered nanostructures can act as vehicles for a large number of signaling centers and/or targeting units thereby offering unique opportunity to enhance the sensitivity by locally enhancing the density of signal groups. For this purpose, creation of surface groups enabling chemical attachment of antibodies or other targeting biomolecules are essential that will allow the delivery of therapeutic payloads to the diseased sites. Multimodal nanoprobes functionalized with different diagnostic and therapeutic options within a single nanoparticle followed by their functionalization with organic ligands and biomolecules can provide specific uptake and high sensitivity toward anatomical information. However, the vision of making clinical theranostics a routine clinical procedure is encumbered by limited stability of complex nanoparticles in biological milieu and lack of standardization of therapy response. Despite the widely acclaimed advantages of integrating diagnostic imaging, drug delivery, and therapeutic monitoring in a single nanotheranostic probe, the clinical utilization of engineered nanoprobes demands concerted efforts in the domains of nanoparticle and surface chemistry/charge, new chelator ligands, pharmaceutical technology, radioactive labeling of nanovectors, biokinetics, and pharmacodynamics of nanoprobes, and biological tests (cell tests and animal models).
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| 12. |
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| 13. |
- Pyo, Sang-Hyun, et al.
(author)
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Sugar Esters
- 2019. - 2nd
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In: Biobased Surfactants : Synthesis, Properties, and Applications - Synthesis, Properties, and Applications. - 9780128127056 ; , s. 325-363
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Book chapter (pop. science, debate, etc.)abstract
- Sugar esters (SEs), value-added products derived from inexpensive renewable feedstocks (sugars and fatty acids), are biobased and biocompatible surfactants employed in foods, personal care products, and pharmaceuticals. They also possess antimicrobial and other biological activities. Their market size is projected to be $74.6 million by 2020. SEs are difficult to synthesize due to the poor miscibility of acyl donor and acceptor reactants and the challenges associated with water activity control during the time course of reaction and controlling the selectivity of the reaction. In this chapter, the catalytic and enzymatic syntheses of SEs in the presence of solvent and under solvent-free conditions are reviewed, in addition to properties and applications.
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| 14. |
- Rogelj, Joeri, et al.
(author)
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Mitigation pathways compatible with 1.5°C in the context of sustainable development
- 2018
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In: Global Warming of 1.5°C. An IPCC Special Report on the impacts of global warming of 1.5°C above pre-industrial levels and related global greenhouse gas emission pathways, in the context of strengthening the global response to the threat of climate change, sustainable development, and efforts to eradicate poverty. ; , s. 93-174
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Book chapter (peer-reviewed)
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| 15. |
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