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1.	Pocock, Stuart, et al. (author) International differences in treatment effect : do they really exist and why? 2013 In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 34:24, s. 1846-1852 Journal article (peer-reviewed)abstract With the increasing globalization of clinical trials, the opportunity exists to explore potential geographic differences in treatment effect within any major trial. Such geographic differences may arise because of international differences in patient selection, medical practice, or evaluation of outcomes, and such international variations need better documentation in trial reports. Appropriate pre-defined statistical analyses, including statistical tests of interaction regarding geographic heterogeneity in treatment effect, are important. Geographic variations are a particularly tricky form of subgroup analysis: they lack statistical power, are at best hypothesis-generating and can generate more confusion than insight. Referring to key examples, e.g. the PLATO and MERIT-HF, we emphasize the need for caution in interpreting evidence of potential geographic inconsistencies in treatment effect. Although it is appropriate to explore any biological or practical reasons for apparent geographic anomalies in treatment effect, the play of chance is often the most plausible and wise interpretation.
2.	Regitz-Zagrosek, Vera, et al. (author) ESC Guidelines on the management of cardiovascular diseases during pregnancy : The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC) 2011 In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 32:24, s. 3147-3197 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kolh, Philippe (1); Knuuti, Juhani (1); Torbicki, Adam (1); Windecker, Stephan (1); Dean, Veronica (1); Iung, Bernard (1); show more...; McDonagh, Theresa (1); Zannad, Faiez (1); Tavazzi, Luigi (1); Price, Susanna (1); Deaton, Christi (1); Gibbs, J. Simon R. (1); Wallentin, Lars (1); Pasquet, Agnes (1); Vejlstrup, Niels (1); Blomstrom-Lundqvist, ... (1); Lip, Gregory Y H (1); Morais, Joao (1); Pocock, Stuart (1); Marrugat, Jaume (1); Auricchio, Angelo (1); Gorenek, Bulent (1); Reiner, Zeljko (1); Borghi, Claudio (1); Gohlke-Baerwolf, Chr ... (1); Schaufelberger, Mari ... (1); Hasdai, David (1); Baumgartner, Helmut (1); Roos-Hesselink, Joli ... (1); Fagard, Robert (1); Nihoyannopoulos, Pet ... (1); Cifkova, Renata (1); Kiss, Robert Gabor (1); Popescu, Bogdan A. (1); Priori, Silvia G (1); Sechtem, Udo (1); Morice, Marie-Claude (1); Prasad, Krishna (1); Ceconi, Claudio (1); Funck-Brentano, Chri ... (1); Hoes, Arno (1); Moulin, Cyril (1); Vahanian, Alec (1); Al-Attar, Nawwar (1); Bax, Jeroen (1); Sirnes, Per Anton (1); Foidart, Jean-Michel (1); Maas, Angela H. E. M ... (1); Presbitero, Patrizia (1); Aguiar, Carlos (1); show less...

University: Uppsala University (2); University of Gothenburg (1)

Language: English (2)

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