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1.	Garcia-Closas, M, et al. (author) Genome-wide association studies identify four ER negative-specific breast cancer risk loci 2013 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:4, s. 392-398 Journal article (peer-reviewed)
2.	Abrahamsson, Per-Anders, et al. (author) Advances in Biomarkers for Prostate Diseases 2006 In: Prostate Cancer. ; , s. 85-85 Book chapter (other academic/artistic)
3.	Mertz, KD, et al. (author) TMPRSS2-ERG fusion prostate cancer is a molecularly distinct estrogen-sensitive subclass of aggressive prostate cancer 2008 In: LABORATORY INVESTIGATION. - 0023-6837. ; 21, s. 171A-171A Conference paper (other academic/artistic)
4.	Tomlins, Scott A., et al. (author) The role of SPINK1 in ETS rearrangement-negative prostate cancers 2008 In: Cancer Cell. - Amsterdam : Elsevier. - 1535-6108 .- 1878-3686. ; 13:6, s. 519-28 Journal article (peer-reviewed)abstract ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers.

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Type of publication: journal article (2); conference paper (1); book chapter (1)

Type of content: other academic/artistic (2); peer-reviewed (2)

Author/Editor: Chen, C. (1); Lilja, Hans (1); Jones, M. (1); Tang, J. (1); Muller, H. (1); Abrahamsson, Per-And ... (1); show more...; Weiderpass, E (1); Miao, H. (1); Zheng, W. (1); Benitez, J. (1); Miller, N (1); Brenner, H (1); Clavel-Chapelon, F. (1); Kaaks, R. (1); Tumino, R. (1); Riboli, E. (1); Kang, D. (1); Yu, S. (1); Dennis, J (1); Wang, Q. (1); Bernard, L. (1); Ito, H. (1); Kerbrat, P (1); Blomqvist, C (1); Mehra, Rohit (1); Cai, H. (1); Shu, XO (1); Gao, YT (1); Hall, P (1); Czene, K (1); Canto, E.I. (1); Chinnaiyan, A.M. (1); Djavan, B. (1); Laxman, B. (1); Ogawa, O. (1); Slawin, K. (1); Tomlins, S.A. (1); McConnell, J. (1); Denis, L. (1); Akaza, H. (1); Khoury, S. (1); Schalken, J (1); Johansson, M (1); Lindblom, A (1); Peterlongo, P (1); Anton-Culver, H (1); Greco, D (1); Adami, HO (1); Giles, GG (1); Milne, RL (1); show less...

University: Karolinska Institutet (3); Lund University (2); Örebro University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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