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Träfflista för sökning "WFRF:(Håkansson Niclas) ;pers:(Chenevix Trench Georgia)"

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1.	Kapoor, Pooja Middha, et al. (author) Combined associations of a polygenic risk score and classical risk factors with breast cancer risk 2021 In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 113:3, s. 329-337 Journal article (peer-reviewed)abstract We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
2.	Wu, Lang, et al. (author) A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 2018 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:7, s. 968-978 Journal article (peer-reviewed)abstract , including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Olsson, Håkan (2); Chang-Claude, Jenny (2); Kaaks, Rudolf (2); Wang, Qin (2); Wolk, Alicja (2); Haiman, Christopher ... (2); show more...; Gapstur, Susan M (2); Giles, Graham G (2); Brenner, Hermann (2); John, Esther M (2); Neuhausen, Susan L (2); Gago Dominguez, Manu ... (2); Eriksson, Mikael (2); Arndt, Volker (2); Rennert, Gad (2); Canzian, Federico (2); Michailidou, Kyriaki (2); Milne, Roger L. (2); Bolla, Manjeet K. (2); Dennis, Joe (2); Dunning, Alison M. (2); Andrulis, Irene L. (2); Anton-Culver, Hoda (2); Aronson, Kristan J. (2); Auer, Paul L. (2); Benitez, Javier (2); Bojesen, Stig E. (2); Brauch, Hiltrud (2); Chenevix-Trench, Geo ... (2); Clarke, Christine L. (2); Cox, Angela (2); Cross, Simon S. (2); Czene, Kamila (2); Fasching, Peter A. (2); Figueroa, Jonine (2); Gaudet, Mia M. (2); Gonzalez-Neira, Anna (2); Guenel, Pascal (2); Hall, Per (2); Hamann, Ute (2); Hoover, Robert N. (2); Hopper, John L. (2); Jones, Michael E. (2); Jung, Audrey (2); Lambrechts, Diether (2); Lissowska, Jolanta (2); MacInnis, Robert J. (2); Sandler, Dale P. (2); Shu, Xiao-Ou (2); Southey, Melissa C. (2); show less...

University: Uppsala University (2); Karolinska Institutet (2); Lund University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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