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1.	Bhangu, A, et al. (author) Mortality of emergency abdominal surgery in high-, middle- and low-income countries 2016 In: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 103:8, s. 971-988 Journal article (peer-reviewed)
2.	Abe, O, et al. (author) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials 2005 In: Lancet (London, England). - 1474-547X. ; 366:9503, s. 2087-2106 Journal article (peer-reviewed)
3.	Wood, AR, et al. (author) Defining the role of common variation in the genomic and biological architecture of adult human height 2014 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186 Journal article (peer-reviewed)
4.	Huckins, LM, et al. (author) Gene expression imputation across multiple brain regions provides insights into schizophrenia risk 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:4, s. 659- Journal article (peer-reviewed)
5.	Mikus, Maria, et al. (author) Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux 2019 In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 53:6 Journal article (other academic/artistic)
6.	Östling, Jörgen, et al. (author) IL-17-high asthma with features of a psoriasis immunophenotype 2019 In: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 144:5, s. 1198-1213 Journal article (peer-reviewed)abstract Background: The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required.Objective: We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity.Methods: Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n = 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes.Results: Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and β-defensin.Conclusion: The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
7.	Schofield, JPR, et al. (author) Stratification of asthma phenotypes by airway proteomic signatures 2019 In: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 144:1, s. 70-82 Journal article (peer-reviewed)
8.	Ripke, S, et al. (author) Biological insights from 108 schizophrenia-associated genetic loci 2014 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 511:7510, s. 421- Journal article (peer-reviewed)
9.	Marshall, CR, et al. (author) Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:1, s. 27-35 Journal article (peer-reviewed)
10.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

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Result 1-10 of 44

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Type of publication: journal article (43); research review (1)

Type of content: peer-reviewed (42); other academic/artistic (2)

Author/Editor: Sjöberg, Staffan (7); Brown, Paul L. (6); Powell, Kipton J. (6); Byrne, Robert H. (6); Gajda, Tamás (6); Hefter, Glenn (6); show more...; Wanner, Hans (6); Williams, S. (5); Andersen, Peter M. (5); Al-Chalabi, Ammar (5); Shatunov, Aleksey (5); Fogh, Isabella (5); Silani, Vincenzo (5); Shaw, Christopher E. (5); Shaw, Pamela J. (5); Morrison, Karen E. (5); Robberecht, Wim (5); Ahmed, H. (4); Powell, J (4); Magnusson, PKE (4); Hofman, A (4); Nothen, MM (4); van Damme, Philip (4); Hardiman, Orla (4); Ticozzi, Nicola (4); Veldink, Jan H. (4); van den Berg, Leonar ... (4); Landers, John E. (4); Glass, Jonathan D. (4); Ripke, S (4); Severi, Gianluca (4); Powell, John (4); Esko, T (4); Metspalu, A (4); Salomaa, V (4); Franke, L (4); Visscher, PM (4); Milani, L (4); Emanuelsson, Monica (4); Leuz, Ann-Kathrin (4); Gejman, PV (4); Meininger, Vincent (4); van Es, Michael A (4); Brown, Robert H (4); Karjalainen, J. (4); Hirschhorn, JN (4); Lewis, Cathryn M (4); Pers, TH (4); Gellera, Cinzia (4); Lin, Kuang (4); show less...

University: Umeå University (44)Undo refine; Karolinska Institutet (16); Uppsala University (7); University of Gothenburg (5); Lund University (5); Royal Institute of Technology (2); show more...; Högskolan Dalarna (2); Stockholm University (1); Linnaeus University (1); show less...

Language: English (44)

Research subject (UKÄ/SCB): Medical and Health Sciences (25); Natural sciences (10); Humanities (1)

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