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Träfflista för sökning "WFRF:(Padyukov L) ;pers:(Saevarsdottir S);srt2:(2015-2019)"

Search: WFRF:(Padyukov L) > Saevarsdottir S > (2015-2019)

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1.	Sieberts, SK, et al. (author) Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12460- Journal article (peer-reviewed)abstract Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h2=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
2.	Manivel, Vivek Anand, et al. (author) Anti-Collagen Type Ii Antibodies Are Associated With An Acute Onset Rheumatoid Arthritis Phenotype And Prognosticate Lower Degree Of Inflammation 2017 In: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd and European League Against Rheumatism. - 0003-4967 .- 1468-2060. ; 76, s. 228-228 Journal article (other academic/artistic)
3.	Hensvold, AH, et al. (author) Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate 2015 In: Arthritis research & therapy. - : Springer Science and Business Media LLC. - 1478-6362 .- 1478-6354. ; 17, s. 239- Journal article (peer-reviewed)
4.	Jiang, X, et al. (author) A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study 2016 In: Arthritis research & therapy. - : Springer Science and Business Media LLC. - 1478-6362. ; 18:1, s. 288- Journal article (peer-reviewed)

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Type of publication: journal article (4)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Saevarsdottir, S (4)Undo refine; Padyukov, L (4); KLARESKOG, L (2); Alfredsson, L (2); Wang, T. (1); Xie, Y. (1); show more...; Aittokallio, T (1); Tang, J. (1); Zhao, C. (1); Wang, B. (1); Gregersen, PK (1); Khan, SA (1); Jiang, X. (1); Manivel, Vivek Anand (1); Catrina, AI (1); Cheng, L (1); Mariette, X (1); Rönnelid, Johan (1); Aguilar, D (1); Oliva, B (1); Tang, H (1); Huizinga, TWJ (1); Mangravite, LM (1); De Vries, N (1); Pirinen, M (1); Saarela, J. (1); Michaud, K (1); Weinblatt, M (1); Neto, EC (1); Dillenberger, D (1); Guan, YF (1); Stolovitzky, G (1); Xiao, GH (1); Zhan, XW (1); Zhu, F (1); Miceli, C (1); Frisell, T (1); Israelsson, L (1); Joshua, V (1); Wennerberg, K (1); Stahl, E (1); Hensvold, AH (1); Askling, J (1); Greenberg, J. (1); Westerlind, H (1); Lundberg, K. (1); Barton, A. (1); Boeva, V (1); Coenen, M (1); Tak, PP (1); show less...

University: Karolinska Institutet (4); Uppsala University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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