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Neuron-glia communi...
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Filosa, Alessandro
(author)
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-09-06
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Springer Science and Business Media LLC,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-127513
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127513URI
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https://doi.org/10.1038/nn.2394DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to regulate neuron-glia interactions, and EphA4-mediated ephrin reverse signaling is required for synaptic plasticity in the hippocampus. Here we show that long-term potentiation (LTP) at the CA3-CA1 synapse is modulated by EphA4 in the postsynaptic CA1 cell and by ephrin-A3, a ligand of EphA4 that is found in astrocytes. Lack of EphA4 increased the abundance of glial glutamate transporters, and ephrin-A3 modulated transporter currents in astrocytes. Pharmacological inhibition of glial glutamate transporters rescued the LTP defects in EphA4 (Epha4) and ephrin-A3 (Efna3) mutant mice. Transgenic overexpression of ephrin-A3 in astrocytes reduces glutamate transporter levels and produces focal dendritic swellings possibly caused by glutamate excitotoxicity. These results suggest that EphA4/ephrin-A3 signaling is a critical mechanism for astrocytes to regulate synaptic function and plasticity.
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Paixao, Sonia
(author)
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Honsek, Silke D.
(author)
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Carmona, Maria A.
(author)
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Becker, Lore
(author)
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Feddersen, Berend
(author)
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Gaitanos, Louise
(author)
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Rudhard, York
(author)
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Schoepfer, Ralf
(author)
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Klopstock, Thomas
(author)
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Kullander, KlasUppsala universitet,Genetisk utvecklingsbiologi(Swepub:uu)klkul255
(author)
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Rose, Christine R.
(author)
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Pasquale, Elena B.
(author)
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Klein, Ruediger
(author)
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Uppsala universitetGenetisk utvecklingsbiologi
(creator_code:org_t)
Related titles
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In:Nature Neuroscience: Springer Science and Business Media LLC12:10, s. 1285-12921097-62561546-1726
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Filosa, Alessand ...
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Paixao, Sonia
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Honsek, Silke D.
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Carmona, Maria A ...
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Becker, Lore
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Feddersen, Beren ...
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Gaitanos, Louise
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Rudhard, York
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Schoepfer, Ralf
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Klopstock, Thoma ...
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Kullander, Klas
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Rose, Christine ...
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Pasquale, Elena ...
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Klein, Ruediger
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Nature Neuroscie ...
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Uppsala University