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  • Filosa, Alessandro (author)

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-09-06
  • Springer Science and Business Media LLC,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-127513
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-127513URI
  • https://doi.org/10.1038/nn.2394DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to regulate neuron-glia interactions, and EphA4-mediated ephrin reverse signaling is required for synaptic plasticity in the hippocampus. Here we show that long-term potentiation (LTP) at the CA3-CA1 synapse is modulated by EphA4 in the postsynaptic CA1 cell and by ephrin-A3, a ligand of EphA4 that is found in astrocytes. Lack of EphA4 increased the abundance of glial glutamate transporters, and ephrin-A3 modulated transporter currents in astrocytes. Pharmacological inhibition of glial glutamate transporters rescued the LTP defects in EphA4 (Epha4) and ephrin-A3 (Efna3) mutant mice. Transgenic overexpression of ephrin-A3 in astrocytes reduces glutamate transporter levels and produces focal dendritic swellings possibly caused by glutamate excitotoxicity. These results suggest that EphA4/ephrin-A3 signaling is a critical mechanism for astrocytes to regulate synaptic function and plasticity.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Paixao, Sonia (author)
  • Honsek, Silke D. (author)
  • Carmona, Maria A. (author)
  • Becker, Lore (author)
  • Feddersen, Berend (author)
  • Gaitanos, Louise (author)
  • Rudhard, York (author)
  • Schoepfer, Ralf (author)
  • Klopstock, Thomas (author)
  • Kullander, KlasUppsala universitet,Genetisk utvecklingsbiologi(Swepub:uu)klkul255 (author)
  • Rose, Christine R. (author)
  • Pasquale, Elena B. (author)
  • Klein, Ruediger (author)
  • Uppsala universitetGenetisk utvecklingsbiologi (creator_code:org_t)

Related titles

  • In:Nature Neuroscience: Springer Science and Business Media LLC12:10, s. 1285-12921097-62561546-1726

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