The Beta common (betac) family of cytokines, receptors and ligands / Angel Lopez and Timothy Hercus.

• Contents: Beta common cytokines -- Excessive beta common cytokine function results in inflammatory diseases -- Function through heterodimeric receptors -- The alpha subunits have a conserved architecture -- The beta subunit -- Formation of a soluble GM-CSF receptor complex -- Key interaction between cytokine and beta common, Site 2 -- Structure of soluble GM-CSF receptor complex -- Crystal structure revealed a higher-order complex -- Key dodecamer interactions are essential for receptor signalling -- Knowledge of receptor activation mechanism contributes to inhibitor development.

Subject headings

Ligands.  (LCSH)

B cells  -- Receptors. (LCSH)

Cytokines  -- Receptors. (LCSH)

Cytokine Receptor Common beta Subunit.  (MeSH)

Cytokines.  (MeSH)

Ligands.  (MeSH)