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Thymic Development and Selection of T Lymphocytes / edited by Thomas Boehm, Yousuke Takahama.
- Boehm, Thomas. (editor)
- Takahama, Yousuke. (editor)
- ISBN 9783642402524
- Berlin, Heidelberg : Springer Berlin Heidelberg : 2014
- English VII, 132 p. 11 illus., 9 illus. in color.
- Series: Current Topics in Microbiology and Immunology, 0070-217X ; 373
- swepub:Mat__t
Table of contents
Abstract
Subject headings
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- Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
- The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
Subject headings
- Medicine. (LCSH)
- Human genetics. (LCSH)
- Human physiology. (LCSH)
- Immunology. (LCSH)
- Biomedicine.
- Immunology.
- Human Physiology.
- Cytogenetics.
Publication and Content Type
- QR180-189.5 (LCC)
- MED044000 (subject category)
- 616.079 (DDC)
- Vad (kssb/8 (machine generated))
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