onr:"19659859"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08427naa a22019933a 4500 | |
| 001 | 19659859 | |
| 003 | SE-LIBR | |
| 005 | 20160906165501.0 | |
| 007 | cr|||||||||||| | |
| 008 | 160906s2011 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1044952 uri |
| 024 | 7 | a urn:nbn:se:umu:diva-1044952 urn |
| 024 | 7 | a 10.1371/journal.pgen.10013332 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a McKay, James D.4 aut |
| 245 | 1 0 | a A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortiumh [Elektronisk resurs] |
| 260 | c 2011 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p <= 5 x 10(-7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1 x 10(-8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2 x 10(-8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 x 10(-8); rs1229984-ADH1B, p = 7 x 10(-9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Basic Medicine2 hsv |
| 650 | 7 | a Medical Genetics2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Medicinska grundvetenskaper2 hsv |
| 650 | 7 | a Medicinsk genetik2 hsv |
| 700 | 1 | a Truong, Therese4 aut |
| 700 | 1 | a Gaborieau, Valerie4 aut |
| 700 | 1 | a Chabrier, Amelie4 aut |
| 700 | 1 | a Chuang, Shu-Chun4 aut |
| 700 | 1 | a Byrnes, Graham4 aut |
| 700 | 1 | a Zaridze, David4 aut |
| 700 | 1 | a Shangina, Oxana4 aut |
| 700 | 1 | a Szeszenia-Dabrowska, Neonila4 aut |
| 700 | 1 | a Lissowska, Jolanta4 aut |
| 700 | 1 | a Rudnai, Peter4 aut |
| 700 | 1 | a Fabianova, Eleonora4 aut |
| 700 | 1 | a Bucur, Alexandru4 aut |
| 700 | 1 | a Bencko, Vladimir4 aut |
| 700 | 1 | a Holcatova, Ivana4 aut |
| 700 | 1 | a Janout, Vladimir4 aut |
| 700 | 1 | a Foretova, Lenka4 aut |
| 700 | 1 | a Lagiou, Pagona4 aut |
| 700 | 1 | a Trichopoulos, Dimitrios4 aut |
| 700 | 1 | a Benhamou, Simone4 aut |
| 700 | 1 | a Bouchardy, Christine4 aut |
| 700 | 1 | a Ahrens, Wolfgang4 aut |
| 700 | 1 | a Merletti, Franco4 aut |
| 700 | 1 | a Richiardi, Lorenzo4 aut |
| 700 | 1 | a Talamini, Renato4 aut |
| 700 | 1 | a Barzan, Luigi4 aut |
| 700 | 1 | a Kjaerheim, Kristina4 aut |
| 700 | 1 | a Macfarlane, Gary J.4 aut |
| 700 | 1 | a Macfarlane, Tatiana V.4 aut |
| 700 | 1 | a Simonato, Lorenzo4 aut |
| 700 | 1 | a Canova, Cristina4 aut |
| 700 | 1 | a Agudo, Antonio4 aut |
| 700 | 1 | a Castellsague, Xavier4 aut |
| 700 | 1 | a Lowry, Ray4 aut |
| 700 | 1 | a Conway, David I.4 aut |
| 700 | 1 | a McKinney, Patricia A.4 aut |
| 700 | 1 | a Healy, Claire M.4 aut |
| 700 | 1 | a Toner, Mary E.4 aut |
| 700 | 1 | a Znaor, Ariana4 aut |
| 700 | 1 | a Curado, Maria Paula4 aut |
| 700 | 1 | a Koifman, Sergio4 aut |
| 700 | 1 | a Menezes, Ana4 aut |
| 700 | 1 | a Wuensch-Filho, Victor4 aut |
| 700 | 1 | a Neto, Jose Eluf4 aut |
| 700 | 1 | a Fernandez Garrote, Leticia4 aut |
| 700 | 1 | a Boccia, Stefania4 aut |
| 700 | 1 | a Cadoni, Gabriella4 aut |
| 700 | 1 | a Arzani, Dario4 aut |
| 700 | 1 | a Olshan, Andrew F.4 aut |
| 700 | 1 | a Weissler, Mark C.4 aut |
| 700 | 1 | a Funkhouser, William K.4 aut |
| 700 | 1 | a Luo, Jingchun4 aut |
| 700 | 1 | a Lubinski, Jan4 aut |
| 700 | 1 | a Trubicka, Joanna4 aut |
| 700 | 1 | a Lener, Marcin4 aut |
| 700 | 1 | a Oszutowska, Dorota4 aut |
| 700 | 1 | a Schwartz, Stephen M.4 aut |
| 700 | 1 | a Chen, Chu4 aut |
| 700 | 1 | a Fish, Sherianne4 aut |
| 700 | 1 | a Doody, David R.4 aut |
| 700 | 1 | a Muscat, Joshua E.4 aut |
| 700 | 1 | a Lazarus, Philip4 aut |
| 700 | 1 | a Gallagher, Carla J.4 aut |
| 700 | 1 | a Chang, Shen-Chih4 aut |
| 700 | 1 | a Zhang, Zuo-Feng4 aut |
| 700 | 1 | a Wei, Qingyi4 aut |
| 700 | 1 | a Sturgis, Erich M.4 aut |
| 700 | 1 | a Wang, Li-E4 aut |
| 700 | 1 | a Franceschi, Silvia4 aut |
| 700 | 1 | a Herrero, Rolando4 aut |
| 700 | 1 | a Kelsey, Karl T.4 aut |
| 700 | 1 | a McClean, Michael D.4 aut |
| 700 | 1 | a Marsit, Carmen J.4 aut |
| 700 | 1 | a Nelson, Heather H.4 aut |
| 700 | 1 | a Romkes, Marjorie4 aut |
| 700 | 1 | a Buch, Shama4 aut |
| 700 | 1 | a Nukui, Tomoko4 aut |
| 700 | 1 | a Zhong, Shilong4 aut |
| 700 | 1 | a Lacko, Martin4 aut |
| 700 | 1 | a Manni, Johannes J.4 aut |
| 700 | 1 | a Peters, Wilbert H. M.4 aut |
| 700 | 1 | a Hung, Rayjean J.4 aut |
| 700 | 1 | a McLaughlin, John4 aut |
| 700 | 1 | a Vatten, Lars4 aut |
| 700 | 1 | a Njolstad, Inger4 aut |
| 700 | 1 | a Goodman, Gary E.4 aut |
| 700 | 1 | a Field, John K.4 aut |
| 700 | 1 | a Liloglou, Triantafillos4 aut |
| 700 | 1 | a Vineis, Paolo4 aut |
| 700 | 1 | a Clavel-Chapelon, Francoise4 aut |
| 700 | 1 | a Palli, Domenico4 aut |
| 700 | 1 | a Tumino, Rosario4 aut |
| 700 | 1 | a Krogh, Vittorio4 aut |
| 700 | 1 | a Panico, Salvatore4 aut |
| 700 | 1 | a Gonzalez, Carlos A.4 aut |
| 700 | 1 | a Ramon Quiros, J.4 aut |
| 700 | 1 | a Martinez, Carmen4 aut |
| 700 | 1 | a Navarro, Carmen4 aut |
| 700 | 1 | a Ardanaz, Eva4 aut |
| 700 | 1 | a Larranaga, Nerea4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Key, Timothy4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
| 700 | 1 | a Peeters, Petra H. M.4 aut |
| 700 | 1 | a Trichopoulou, Antonia4 aut |
| 700 | 1 | a Linseisen, Jakob4 aut |
| 700 | 1 | a Boeing, Heiner4 aut |
| 700 | 1 | a Hallmans, Göran4 aut |
| 700 | 1 | a Overvad, Kim4 aut |
| 700 | 1 | a Tjonneland, Anne4 aut |
| 700 | 1 | a Kumle, Merethe4 aut |
| 700 | 1 | a Riboli, Elio4 aut |
| 700 | 1 | a Vaelk, Kristjan4 aut |
| 700 | 1 | a Voodern, Tonu4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Zelenika, Diana4 aut |
| 700 | 1 | a Boland, Anne4 aut |
| 700 | 1 | a Delepine, Marc4 aut |
| 700 | 1 | a Foglio, Mario4 aut |
| 700 | 1 | a Lechner, Doris4 aut |
| 700 | 1 | a Blanche, Helene4 aut |
| 700 | 1 | a Gut, Ivo G.4 aut |
| 700 | 1 | a Galan, Pilar4 aut |
| 700 | 1 | a Heath, Simon4 aut |
| 700 | 1 | a Hashibe, Mia4 aut |
| 700 | 1 | a Hayes, Richard B.4 aut |
| 700 | 1 | a Boffetta, Paolo4 aut |
| 700 | 1 | a Lathrop, Mark4 aut |
| 700 | 1 | a Brennan, Paul4 aut |
| 710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
| 710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
| 772 | 1 8 | i channel recordw 18813935 |
| 773 | 0 | i Värdpublikationt PLOS Geneticsg 7 3x 1553-7390 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104495 |
| 856 | 4 0 | u http://dx.doi.org/10.1371/journal.pgen.1001333 |
| 856 | 4 0 | u http://umu.diva-portal.org/smash/get/diva2:820649/FULLTEXT01 |
| 910 | 2 s | 6 710,710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten |
| 910 | 2 s | 6 710,710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten |
| 841 | 5 APISa x ab 160906||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:umu:diva-1044952 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104495 |
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- McKay, James D.
- Truong, Therese
- Gaborieau, Valer ...
- Chabrier, Amelie
- Chuang, Shu-Chun
- Byrnes, Graham
- visa fler...
- Zaridze, David
- Shangina, Oxana
- Szeszenia-Dabrow ...
- Lissowska, Jolan ...
- Rudnai, Peter
- Fabianova, Eleon ...
- Bucur, Alexandru
- Bencko, Vladimir
- Holcatova, Ivana
- Janout, Vladimir
- Foretova, Lenka
- Lagiou, Pagona
- Trichopoulos, Di ...
- Benhamou, Simone
- Bouchardy, Chris ...
- Ahrens, Wolfgang
- Merletti, Franco
- Richiardi, Loren ...
- Talamini, Renato
- Barzan, Luigi
- Kjaerheim, Krist ...
- Macfarlane, Gary ...
- Macfarlane, Tati ...
- Simonato, Lorenz ...
- Canova, Cristina
- Agudo, Antonio
- Castellsague, Xa ...
- Lowry, Ray
- Conway, David I.
- McKinney, Patric ...
- Healy, Claire M.
- Toner, Mary E.
- Znaor, Ariana
- Curado, Maria Pa ...
- Koifman, Sergio
- Menezes, Ana
- Wuensch-Filho, V ...
- Neto, Jose Eluf
- Fernandez Garrot ...
- Boccia, Stefania
- Cadoni, Gabriell ...
- Arzani, Dario
- Olshan, Andrew F ...
- Weissler, Mark C ...
- Funkhouser, Will ...
- Luo, Jingchun
- Lubinski, Jan
- Trubicka, Joanna
- Lener, Marcin
- Oszutowska, Doro ...
- Schwartz, Stephe ...
- Chen, Chu
- Fish, Sherianne
- Doody, David R.
- Muscat, Joshua E ...
- Lazarus, Philip
- Gallagher, Carla ...
- Chang, Shen-Chih
- Zhang, Zuo-Feng
- Wei, Qingyi
- Sturgis, Erich M ...
- Wang, Li-E
- Franceschi, Silv ...
- Herrero, Rolando
- Kelsey, Karl T.
- McClean, Michael ...
- Marsit, Carmen J ...
- Nelson, Heather ...
- Romkes, Marjorie
- Buch, Shama
- Nukui, Tomoko
- Zhong, Shilong
- Lacko, Martin
- Manni, Johannes ...
- Peters, Wilbert ...
- Hung, Rayjean J.
- McLaughlin, John
- Vatten, Lars
- Njolstad, Inger
- Goodman, Gary E.
- Field, John K.
- Liloglou, Triant ...
- Vineis, Paolo
- Clavel-Chapelon, ...
- Palli, Domenico
- Tumino, Rosario
- Krogh, Vittorio
- Panico, Salvator ...
- Gonzalez, Carlos ...
- Ramon Quiros, J.
- Martinez, Carmen
- Navarro, Carmen
- Ardanaz, Eva
- Larranaga, Nerea
- Khaw, Kay-Tee
- Key, Timothy
- Bueno-de-Mesquit ...
- Peeters, Petra H ...
- Trichopoulou, An ...
- Linseisen, Jakob
- Boeing, Heiner
- Hallmans, Göran
- Overvad, Kim
- Tjonneland, Anne
- Kumle, Merethe
- Riboli, Elio
- Vaelk, Kristjan
- Voodern, Tonu
- Metspalu, Andres
- Zelenika, Diana
- Boland, Anne
- Delepine, Marc
- Foglio, Mario
- Lechner, Doris
- Blanche, Helene
- Gut, Ivo G.
- Galan, Pilar
- Heath, Simon
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