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Prospective evaluat...
Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population
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Araujo de Pina Cabral, DB (författare)
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Dantas, JR (författare)
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Skärstrand, H (författare)
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visa fler...
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Barone, B (författare)
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Carvalho, F (författare)
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Tortora, R (författare)
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Milech, A (författare)
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Vaziri-Sani, Fariba (författare)
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Oliveira, JE (författare)
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Zajdenverg, L (författare)
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Rodacki, M (författare)
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visa färre...
- 2015
- 2015
- Engelska.
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Ingår i: Diabetology and Metabolic Syndrome. - 1758-5996. ; 7 52
Abstract
Ämnesord
Stäng
- BACKGROUND: A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean interval of 5 years. FINDINGS: Brazilian FDR (n = 30) of patients with T1D were evaluated and blood was sampled to measure the levels of glutamine and phospholipids in the fasting serum by quantitative colorimetric method. The tests were repeated after a mean interval of 5 years and compared to a control group (n = 20). The FDR presented lower levels of phospholipids than controls (p = 0.028), but not of glutamine (p = 0.075). Phospholipids levels decreased over time (p = 0.028) in FDR and were associated with Glutamic acid decarboxylase autoantibody (GADA) titers (p = 0.045), autoantibody positivity (p = 0.008) and PTPN22 polymorphisms (p = 0.014). CONCLUSIONS: In this Brazilian multiethnic population, there was a significant decrease in phospholipids levels in FDR in patients with T1D during a 5-year prospective follow-up, as well as a significant association between these metabolite, GADA and PTPN22 polymorphisms. For Glutamine no difference was found. These findings suggest that a dysregulation in the metabolism of lipids may precede the onset of the autoimmunity in T1D.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
Nyckelord
- Metabolic
- Diabetes
- Non-whites
- Antibodies
- Multiethnic
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Till lärosätets databas
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Araujo de Pina C ...
-
Dantas, JR
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Skärstrand, H
-
Barone, B
-
Carvalho, F
-
Tortora, R
-
visa fler...
-
Milech, A
-
Vaziri-Sani, Far ...
-
Oliveira, JE
-
Zajdenverg, L
-
Rodacki, M
-
visa färre...
- Av lärosätet
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