Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

doi:10.1038/ncomms9658

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MARC

Soler Artigas, María (author)

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

E-article/E-chapterEnglish2015

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2015

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LIBRIS-ID:20193092
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275522uri
urn:nbn:se:uu:diva-275522urn
10.1038/ncomms9658doi

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Language:English

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deldatabas:Eplk_tEPLK

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Published
Stiftelsen för strategisk forskning (SSF) [ICA08-0047]
Vetenskapsrådet [2012-1397]
Hjärt-Lungfonden [20120197]
Svenska läkaresällskapet
EU, FP7, Sjunde ramprogrammet
Wellcome trust
Swedish National Infrastructure for Computing (SNIC) [b2013056]
gratis
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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Wain, Louise V (author)
Miller, Suzanne (author)
Kheirallah, Abdul Kader (author)
Huffman, Jennifer E (author)
Ntalla, Ioanna (author)
Shrine, Nick (author)
Obeidat, Ma'en (author)
Trochet, Holly (author)
McArdle, Wendy L (author)
Alves, Alexessander Couto (author)
Hui, Jennie (author)
Zhao, Jing Hua (author)
Joshi, Peter K (author)
Teumer, Alexander (author)
Albrecht, Eva (author)
Imboden, Medea (author)
Rawal, Rajesh (author)
Lopez, Lorna M (author)
Marten, Jonathan (author)
Enroth, Stefan (author)
Surakka, Ida (author)
Polasek, Ozren (author)
Lyytikäinen, Leo-Pekka (author)
Granell, Raquel (author)
Hysi, Pirro G (author)
Flexeder, Claudia (author)
Mahajan, Anubha (author)
Beilby, John (author)
Bossé, Yohan (author)
Brandsma, Corry-Anke (author)
Campbell, Harry (author)
Gieger, Christian (author)
Gläser, Sven (author)
González, Juan R (author)
Grallert, Harald (author)
Hammond, Chris J (author)
Harris, Sarah E (author)
Hartikainen, Anna-Liisa (author)
Heliövaara, Markku (author)
Henderson, John (author)
Hocking, Lynne (author)
Horikoshi, Momoko (author)
Hutri-Kähönen, Nina (author)
Ingelsson, Erik (author)
Johansson, Åsa320150 (author)
Kemp, John P (author)
Kolcic, Ivana (author)
Kumar, Ashish (author)
Lind, Lars (author)
Melén, Erik (author)
Musk, Arthur W (author)
Navarro, Pau (author)
Nickle, David C (author)
Padmanabhan, Sandosh (author)
Raitakari, Olli T (author)
Ried, Janina S (author)
Ripatti, Samuli (author)
Schulz, Holger (author)
Scott, Robert A (author)
Sin, Don D (author)
Starr, John M (author)
Viñuela, Ana (author)
Völzke, Henry (author)
Wild, Sarah H (author)
Wright, Alan F (author)
Zemunik, Tatijana (author)
Jarvis, Deborah L (author)
Spector, Tim D (author)
Evans, David M (author)
Lehtimäki, Terho (author)
Vitart, Veronique (author)
Kähönen, Mika (author)
Gyllensten, Ulf (author)
Rudan, Igor (author)
Deary, Ian J (author)
Karrasch, Stefan (author)
Probst-Hensch, Nicole M (author)
Heinrich, Joachim (author)
Stubbe, Beate (author)
Wilson, James F (author)
Wareham, Nicholas J (author)
James, Alan L (author)
Morris, Andrew P (author)
Jarvelin, Marjo-Riitta (author)
Hayward, Caroline (author)
Sayers, Ian (author)
Strachan, David P (author)
Hall, Ian P (author)
Tobin, Martin D (author)
Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
Uppsala universitetScience for Life Laboratory, SciLifeLab (publisher)
Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
Gyllensten (contributor)

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By the author/editor: Soler Artigas, M ...; Wain, Louise V; Miller, Suzanne; Kheirallah, Abdu ...; Huffman, Jennife ...; Ntalla, Ioanna; show more...; Shrine, Nick; Obeidat, Ma'en; Trochet, Holly; McArdle, Wendy L; Alves, Alexessan ...; Hui, Jennie; Zhao, Jing Hua; Joshi, Peter K; Teumer, Alexande ...; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; Lopez, Lorna M; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polasek, Ozren; Lyytikäinen, Leo ...; Granell, Raquel; Hysi, Pirro G; Flexeder, Claudi ...; Mahajan, Anubha; Beilby, John; Bossé, Yohan; Brandsma, Corry- ...; Campbell, Harry; Gieger, Christia ...; Gläser, Sven; González, Juan R; Grallert, Harald; Hammond, Chris J; Harris, Sarah E; Hartikainen, Ann ...; Heliövaara, Mark ...; Henderson, John; Hocking, Lynne; Horikoshi, Momok ...; Hutri-Kähönen, N ...; Ingelsson, Erik; Johansson, Åsa; Kemp, John P; Kolcic, Ivana; Kumar, Ashish; Lind, Lars; Melén, Erik; Musk, Arthur W; Navarro, Pau; Nickle, David C; Padmanabhan, San ...; Raitakari, Olli ...; Ried, Janina S; Ripatti, Samuli; Schulz, Holger; Scott, Robert A; Sin, Don D; Starr, John M; Viñuela, Ana; Völzke, Henry; Wild, Sarah H; Wright, Alan F; Zemunik, Tatijan ...; Jarvis, Deborah ...; Spector, Tim D; Evans, David M; Lehtimäki, Terho; Vitart, Veroniqu ...; Kähönen, Mika; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J; Karrasch, Stefan; Probst-Hensch, N ...; Heinrich, Joachi ...; Stubbe, Beate; Wilson, James F; Wareham, Nichola ...; James, Alan L; Morris, Andrew P; Jarvelin, Marjo- ...; Hayward, Carolin ...; Sayers, Ian; Strachan, David ...; Hall, Ian P; Tobin, Martin D; show less...

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