onr:"20193154"
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- Alexander, Michelle (author)
Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance
- E-article/E-chapterEnglish2015
Publisher, publication year, extent ...
- 2015
Numbers
- LIBRIS-ID:20193154
- http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269992uri
- urn:nbn:se:uu:diva-269992urn
- 10.1098/rsbl.2015.0561doi
Supplementary language notes
- Language:English
Part of subdatabase
Notes
- Published
- EU, Europeiska forskningsrådet [ERC-2013-StG 337574-UNDEAD]
- gratis
- Mitochondrial genomes represent a valuable source of data for evolutionary research, but studies of their short-term evolution have typically been limited to invertebrates, humans and laboratory organisms. Here we present a detailed study of 12 mitochondrial genomes that span a total of 385 transmissions in a well-documented 50-generation pedigree in which two lineages of chickens were selected for low and high juvenile body weight. These data allowed us to test the hypothesis of time-dependent evolutionary rates and the assumption of strict maternal mitochondrial transmission, and to investigate the role of mitochondrial mutations in determining phenotype. The identification of a non-synonymous mutation in ND4L and a synonymous mutation in CYTB, both novel mutations in Gallus, allowed us to estimate a molecular rate of 3.13 x 10(-7) mutations/site/year (95% confidence interval 3.75 x 10(-8)-1.12 x 10(-6)). This is substantially higher than avian rate estimates based upon fossil calibrations. Ascertaining which of the two novel mutations was present in an additional 49 individuals also revealed an instance of paternal inheritance of mtDNA. Lastly, an association analysis demonstrated that neither of the point mutations was strongly associated with the phenotypic differences between the two selection lines. Together, these observations reveal the highly dynamic nature of mitochondrial evolution over short time periods.
Subject headings and genre
- Medical and Health Sciences hsv
- Basic Medicine hsv
- Other Basic Medicine hsv
- Medicin och hälsovetenskap hsv
- Medicinska grundvetenskaper hsv
- Annan medicinsk grundvetenskap hsv
- Natural Sciences hsv
- Biological Sciences hsv
- Evolutionary Biology hsv
- Naturvetenskap hsv
- Biologiska vetenskaper hsv
- Evolutionsbiologi hsv
- Ecology hsv
- Ekologi hsv
- mitochondrial genome
- pedigree
- mutation rates
- paternal leakage
- association analysis
Added entries (persons, corporate bodies, meetings, titles ...)
- Ho, Simon Y. W. (author)
- Molak, Martyna (author)
- Barnett, Ross (author)
- Carlborg, Örjan (author)
- Dorshorst, Ben (author)
- Honaker, Christa (author)
- Besnier, Francois (author)
- Wahlberg, Per (author)
- Dobney, Keith (author)
- Siegel, Paul (author)
- Andersson, Leif (author)
- Larson, Greger (author)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
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- Part of/supplement to:channel record
- In:VärdpublikationBiology Letters11:101744-9561
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