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- Hallberg, Pär (author)
Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough a genome-wide association study in a Swedish population
- E-article/E-chapterEnglish2017
Publisher, publication year, extent ...
- FUTURE MEDICINE LTD2017
Numbers
- LIBRIS-ID:20217525
- http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318602uri
- urn:nbn:se:uu:diva-318602urn
- 10.2217/pgs-2016-0184doi
Supplementary language notes
- Language:English
Part of subdatabase
Notes
- Published
- Vetenskapsrådet [Medicine 521-2011-2440 521-2014-3370]
- Hjärt-Lungfonden [20120557 20140291]
- Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
- gratis
- Aim: We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes iden-tified in previous studies. Patients & methods: A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. The genome-wide significance level was set to p < 5 x 10(-8). Results: We identified nearly genome-wide significant associations in CLASP1, PDE11A, KCNMB2, TGFA, SLC38A6 and MMP16. The strongest association was with rs62151109 in CLASP1 (odds ratio: 3.97; p = 9.44 x 10(-8)). All top hits except two were located in intronic or noncoding DNA regions. None of the candidate genes were significantly associated in our study. Conclusion: Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways.
Subject headings and genre
- Medical and Health Sciences hsv
- Basic Medicine hsv
- Pharmacology and Toxicology hsv
- Medicin och hälsovetenskap hsv
- Medicinska grundvetenskaper hsv
- Farmakologi och toxikologi hsv
- angiotensin converting enzyme inhibitors
- bradykinin
- cough
- drug-related side effects and adverse reactions
- enalapril
- genome-wide association study
- lisinopril
- pharmacogenetics
- quinapril
- ramipril
Added entries (persons, corporate bodies, meetings, titles ...)
- Persson, Matilda (author)
- Axelsson, Tomas (author)
- Cavalli, Marco (author)
- Norling, Pia (author)
- Johansson, Hans-Erik (author)
- Yue, Qun-Ying (author)
- Magnusson, Patrik K. E. (author)
- Wadelius, Claes (author)
- Eriksson, Niclas (author)
- Wadelius, Mia (author)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
- Uppsala universitetScience for Life Laboratory, SciLifeLab (publisher)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (publisher)
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- In:VärdpublikationPharmacogenomics (London)18:3, 201-2131462-2416
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