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Maternal overweight...
Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes
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Persson, Martina (author)
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Cnattingius, Sven (author)
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Wikström, Anna-Karin (author)
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Johansson, Stefan (author)
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(publisher)
- 2016
- 2016
- English.
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In: Diabetologia. - 0012-186X. ; 59:10, 2099-2105
Abstract
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- Aims/hypothesis Women with type 1 or type 2 diabetes are at increased risk of pre-eclampsia. Overweight and obesity are associated with an increased risk of pre-eclampsia in women without diabetes. The aim of the study was to investigate the impact of maternal overweight and obesity on the risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes. MethodsIn a population-based cohort study including singleton births in Sweden, we estimated the risk of pre-eclampsia among women with type 1 diabetes (n = 7062) and type 2 diabetes (n = 886), and investigated whether maternal overweight (BMI 25-29.9 kg/m(2)) and obesity (BMI aeyen30.0 kg/m(2)) modified the risk. Logistic regression analyses were used to estimate crude and adjusted ORs with 95% CIs, using women without diabetes as the reference group (n = 1,509,525). Results Compared with women without diabetes, the adjusted ORs for pre-eclampsia in women with type 1 and type 2 diabetes were 5.74 (95% CI 5.31, 6.20) and 2.11 (95% CI 1.65, 2.70), respectively. The corresponding risks of pre-eclampsia combined with preterm birth were even higher. Risks of pre-eclampsia increased with maternal overweight (BMI 25-29.9 kg/m(2)) and obesity (BMI aeyen30.0 kg/m(2)), foremost in women without diabetes, to a lesser extent in women with type 1 diabetes but not in women with type 2 diabetes. Conclusions/interpretation Maternal overweight and obesity increased risks of pre-eclampsia in women with type 1 diabetes but not in women with type 2 diabetes. Even so, considering associations between maternal BMI and overall maternal and offspring risk, all women (with and without diabetes) should aim for a normal weight before pregnancy.
Subject headings
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Endocrinology and Diabetes (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Endokrinologi och diabetes (hsv)
- Obstetrics, Gynecology and Reproductive Medicine (hsv)
- Reproduktionsmedicin och gynekologi (hsv)
Keyword
- BMI
- Diabetestype 1
- Diabetes type 2
- Moderate pre-eclampsia
- Obesity
- Overweight
- Pre-eclampsia
- Risk of pre-eclampsia
- Severe pre-eclampsia
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