Association of vitamin D status with arterial blood pressure and hypertension risk a mendelian randomisation study

doi:10.1016/S2213-8587(14)70113-5

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Fältnamn	Indikatorer	Metadata
000		08716naa a22017293a 4500
001		22068493
003		SE-LIBR
005		20171206155755.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		171206s2014 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2332642 uri
024	7	a urn:nbn:se:uu:diva-2332642 urn
024	7	a 10.1016/S2213-8587(14)70113-52 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Vimaleswaran, Karani S4 aut
245	1 0	a Association of vitamin D status with arterial blood pressure and hypertension riskh [Elektronisk resurs]b a mendelian randomisation study
260		c 2014
500		a Published
506	0	a gratis
520		a BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. METHODS: In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. FINDINGS: In phenotypic analyses (up to n=49 363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, -0·12 mm Hg, 95% CI -0·20 to -0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97-0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, -0·02 mm Hg, -0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146 581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of -0·10 mm Hg in systolic blood pressure (-0·21 to -0·0001; p=0·0498) and a change of -0·08 mm Hg in diastolic blood pressure (-0·15 to -0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142 255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96-0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of -0·29 mm Hg in diastolic blood pressure (-0·52 to -0·07; p=0·01), a change of -0·37 mm Hg in systolic blood pressure (-0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87-0·97; p=0·002). INTERPRETATION: Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study.
650	7	a Medical and Health Sciences2 hsv
650	7	a Clinical Medicine2 hsv
650	7	a Endocrinology and Diabetes2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
650	7	a Klinisk medicin2 hsv
650	7	a Endokrinologi och diabetes2 hsv
700	1	a Cavadino, Alana4 aut
700	1	a Berry, Diane J4 aut
700	1	a Jorde, Rolf4 aut
700	1	a Dieffenbach, Aida Karina4 aut
700	1	a Lu, Chen4 aut
700	1	a Alves, Alexessander Couto4 aut
700	1	a Heerspink, Hiddo J Lambers4 aut
700	1	a Tikkanen, Emmi4 aut
700	1	a Eriksson, Joel4 aut
700	1	a Wong, Andrew4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Jablonski, Kathleen A4 aut
700	1	a Nolte, Ilja M4 aut
700	1	a Houston, Denise K4 aut
700	1	a Ahluwalia, Tarunveer Singh4 aut
700	1	a van der Most, Peter J4 aut
700	1	a Pasko, Dorota4 aut
700	1	a Zgaga, Lina4 aut
700	1	a Thiering, Elisabeth4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Fraser, Ross M4 aut
700	1	a Huffman, Jennifer E4 aut
700	1	a de Boer, Rudolf A4 aut
700	1	a Schöttker, Ben4 aut
700	1	a Saum, Kai-Uwe4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Dupuis, Josée4 aut
700	1	a Herzig, Karl-Heinz4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Pouta, Anneli4 aut
700	1	a Laitinen, Jaana4 aut
700	1	a Kleber, Marcus E4 aut
700	1	a Navis, Gerjan4 aut
700	1	a Lorentzon, Mattias4 aut
700	1	a Jameson, Karen4 aut
700	1	a Arden, Nigel4 aut
700	1	a Cooper, Jackie A4 aut
700	1	a Acharya, Jayshree4 aut
700	1	a Hardy, Rebecca4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Billings, Liana K4 aut
700	1	a Lahti, Jari4 aut
700	1	a Osmond, Clive4 aut
700	1	a Penninx, Brenda W4 aut
700	1	a Rejnmark, Lars4 aut
700	1	a Lohman, Kurt K4 aut
700	1	a Paternoster, Lavinia4 aut
700	1	a Stolk, Ronald P4 aut
700	1	a Hernandez, Dena G4 aut
700	1	a Byberg, Liisa4 aut
700	1	a Hagström, Emil4 aut
700	1	a Melhus, Håkan4 aut
700	1	a Ingelsson, Erik4 aut
700	1	a Mellström, Dan4 aut
700	1	a Ljunggren, Östen4 aut
700	1	a Tzoulaki, Ioanna4 aut
700	1	a McLachlan, Stela4 aut
700	1	a Theodoratou, Evropi4 aut
700	1	a Tiesler, Carla M T4 aut
700	1	a Jula, Antti4 aut
700	1	a Navarro, Pau4 aut
700	1	a Wright, Alan F4 aut
700	1	a Polasek, Ozren4 aut
700	1	a Wilson, James F4 aut
700	1	a Rudan, Igor4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Campbell, Harry4 aut
700	1	a Price, Jacqueline F4 aut
700	1	a Karlsson, Magnus4 aut
700	1	a Lind, Lars4 aut
700	1	a Michaëlsson, Karl4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a Hartman, Catharina A4 aut
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Kritchevsky, Stephen B4 aut
700	1	a Langdahl, Bente Lomholt4 aut
700	1	a Eriksson, Johan G4 aut
700	1	a Florez, Jose C4 aut
700	1	a Spector, Tim D4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Kuh, Diana4 aut
700	1	a Humphries, Steve E4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Ohlsson, Claes4 aut
700	1	a März, Winfried4 aut
700	1	a de Borst, Martin H4 aut
700	1	a Kumari, Meena4 aut
700	1	a Kivimaki, Mika4 aut
700	1	a Wang, Thomas J4 aut
700	1	a Power, Chris4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Grimnes, Guri4 aut
700	1	a van der Harst, Pim4 aut
700	1	a Snieder, Harold4 aut
700	1	a Hingorani, Aroon D4 aut
700	1	a Pilz, Stefan4 aut
700	1	a Whittaker, John C4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Hyppönen, Elina4 aut
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt The Lancet Diabetes and Endocrinologyg 2:9, 719-729x 2213-8587
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233264
856	4 0	u http://dx.doi.org/10.1016/S2213-8587(14)70113-5
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:751534/FULLTEXT01
841		5 APISa x ab 171206\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:uu:diva-2332642 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233264

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By the author/editor: Vimaleswaran, Ka ...; Cavadino, Alana; Berry, Diane J; Jorde, Rolf; Dieffenbach, Aid ...; Lu, Chen; show more...; Alves, Alexessan ...; Heerspink, Hiddo ...; Tikkanen, Emmi; Eriksson, Joel; Wong, Andrew; Mangino, Massimo; Jablonski, Kathl ...; Nolte, Ilja M; Houston, Denise ...; Ahluwalia, Tarun ...; van der Most, Pe ...; Pasko, Dorota; Zgaga, Lina; Thiering, Elisab ...; Vitart, Veroniqu ...; Fraser, Ross M; Huffman, Jennife ...; de Boer, Rudolf ...; Schöttker, Ben; Saum, Kai-Uwe; McCarthy, Mark I; Dupuis, Josée; Herzig, Karl-Hei ...; Sebert, Sylvain; Pouta, Anneli; Laitinen, Jaana; Kleber, Marcus E; Navis, Gerjan; Lorentzon, Matti ...; Jameson, Karen; Arden, Nigel; Cooper, Jackie A; Acharya, Jayshre ...; Hardy, Rebecca; Raitakari, Olli; Ripatti, Samuli; Billings, Liana ...; Lahti, Jari; Osmond, Clive; Penninx, Brenda ...; Rejnmark, Lars; Lohman, Kurt K; Paternoster, Lav ...; Stolk, Ronald P; Hernandez, Dena ...; Byberg, Liisa; Hagström, Emil; Melhus, Håkan; Ingelsson, Erik; Mellström, Dan; Ljunggren, Östen; Tzoulaki, Ioanna; McLachlan, Stela; Theodoratou, Evr ...; Tiesler, Carla M ...; Jula, Antti; Navarro, Pau; Wright, Alan F; Polasek, Ozren; Wilson, James F; Rudan, Igor; Salomaa, Veikko; Heinrich, Joachi ...; Campbell, Harry; Price, Jacquelin ...; Karlsson, Magnus; Lind, Lars; Michaëlsson, Kar ...; Bandinelli, Stef ...; Frayling, Timoth ...; Hartman, Cathari ...; Sørensen, Thorki ...; Kritchevsky, Ste ...; Langdahl, Bente ...; Eriksson, Johan ...; Florez, Jose C; Spector, Tim D; Lehtimäki, Terho; Kuh, Diana; Humphries, Steve ...; Cooper, Cyrus; Ohlsson, Claes; März, Winfried; de Borst, Martin ...; Kumari, Meena; Kivimaki, Mika; Wang, Thomas J; Power, Chris; Brenner, Hermann; Grimnes, Guri; van der Harst, P ...; Snieder, Harold; Hingorani, Aroon ...; Pilz, Stefan; Whittaker, John ...; Järvelin, Marjo- ...; Hyppönen, Elina; show less...

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