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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04967naa a22009253a 4500 | |
| 001 | 22081110 | |
| 003 | SE-LIBR | |
| 005 | 20171207151914.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171207s2013 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2066562 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-2066562 urn |
| 024 | 7 | a 10.1371/journal.pgen.10036072 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Ahmad, Shafqat4 aut |
| 245 | 1 0 | a Gene x Physical Activity Interactions in Obesityh [Elektronisk resurs]b Combined Analysis of 111,421 Individuals of European Ancestry |
| 260 | c 2013 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. Twelve obesity-susceptibility loci were genotyped or imputed in 111,421 participants. A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. Physical activity was assessed using self-administered questionnaires. Multiplicative interactions between the GRS and physical activity on BMI were tested in linear and logistic regression models in each cohort, with adjustment for age, age(2), sex, study center (for multicenter studies), and the marginal terms for physical activity and the GRS. These results were combined using meta-analysis weighted by cohort sample size. The meta-analysis yielded a statistically significant GRS x physical activity interaction effect estimate (P-interaction = 0.015). However, a statistically significant interaction effect was only apparent in North American cohorts (n = 39,810, P-interaction = 0.014 vs. n = 71,611, P-interaction = 0.275 for Europeans). In secondary analyses, both the FTO rs1121980 (P-interaction = 0.003) and the SEC16B rs10913469 (P-interaction = 0.025) variants showed evidence of SNP x physical activity interactions. This meta-analysis of 111,421 individuals provides further support for an interaction between physical activity and a GRS in obesity disposition, although these findings hinge on the inclusion of cohorts from North America, indicating that these results are either population-specific or non-causal. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 700 | 1 | a Rukh, Gull4 aut |
| 700 | 1 | a Varga, Tibor V.4 aut |
| 700 | 1 | a Ali, Ashfaq4 aut |
| 700 | 1 | a Kurbasic, Azra4 aut |
| 700 | 1 | a Shungin, Dmitry4 aut |
| 700 | 1 | a Ericson, Ulrika4 aut |
| 700 | 1 | a Koivula, Robert W.4 aut |
| 700 | 1 | a Chu, Audrey Y.4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Ganna, Andrea4 aut |
| 700 | 1 | a Qi, Qibin4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Sandholt, Camilla H.4 aut |
| 700 | 1 | a Elks, Cathy E.4 aut |
| 700 | 1 | a Curhan, Gary4 aut |
| 700 | 1 | a Jensen, Majken K.4 aut |
| 700 | 1 | a Tamimi, Rulla M.4 aut |
| 700 | 1 | a Allin, Kristine H.4 aut |
| 700 | 1 | a Jorgensen, Torben4 aut |
| 700 | 1 | a Brage, Soren4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Aadahl, Mette4 aut |
| 700 | 1 | a Grarup, Niels4 aut |
| 700 | 1 | a Linneberg, Allan4 aut |
| 700 | 1 | a Pare, Guillaume4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.4 aut |
| 700 | 1 | a Pedersen, Nancy L.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Hamsten, Anders4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Pasquale, Louis T.4 aut |
| 700 | 1 | a Pedersen, Oluf4 aut |
| 700 | 1 | a Scott, Robert A.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Ingelsson, Erik4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Hansen, Torben4 aut |
| 700 | 1 | a Qi, Lu4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Hallmans, Goran4 aut |
| 700 | 1 | a Hu, Frank B.4 aut |
| 700 | 1 | a Renstrom, Frida4 aut |
| 700 | 1 | a Orho-Melander, Marju4 aut |
| 700 | 1 | a Franks, Paul W.4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt PLOS Geneticsg 9:7, e1003607x 1553-7390 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206656 |
| 856 | 4 0 | u http://dx.doi.org/10.1371/journal.pgen.1003607 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:645146/FULLTEXT01 |
| 841 | 5 APISa x ab 171207||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-2066562 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206656 |
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