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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04016naa a22006613a 4500 | |
| 001 | 22081621 | |
| 003 | SE-LIBR | |
| 005 | 20171207155111.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171207s2013 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1896932 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-1896932 urn |
| 024 | 7 | a 10.1017/S14611457120011372 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Karpyak, Victor M4 aut |
| 245 | 1 0 | a Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional statesh [Elektronisk resurs] |
| 260 | c 2013 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Synthetic κ-opioid receptor (KOR) agonists induce dysphoric and pro-depressive effects and variations in the KOR (OPRK1) and prodynorphin (PDYN) genes have been shown to be associated with alcohol dependence. We genotyped 23 single nucleotide polymorphisms (SNPs) in the PDYN and OPRK1 genes in 816 alcohol-dependent subjects and investigated their association with: (1) negative craving measured by a subscale of the Inventory of Drug Taking Situations; (2) a self-reported history of depression; (3) the intensity of depressive symptoms measured by the Beck Depression Inventory-II. In addition, 13 of the 23 PDYN and OPRK1 SNPs, which were previously genotyped in a set of 1248 controls, were used to evaluate association with alcohol dependence. SNP and haplotype tests of association were performed. Analysis of a haplotype spanning the PDYN gene (rs6045784, rs910080, rs2235751, rs2281285) revealed significant association with alcohol dependence (p = 0.00079) and with negative craving (p = 0.0499). A candidate haplotype containing the PDYN rs2281285-rs1997794 SNPs that was previously associated with alcohol dependence was also associated with negative craving (p = 0.024) and alcohol dependence (p = 0.0008) in this study. A trend for association between depression severity and PDYN variation was detected. No associations of OPRK1 gene variation with alcohol dependence or other studied phenotypes were found. These findings support the hypothesis that sequence variation in the PDYN gene contributes to both alcohol dependence and the induction of negative craving in alcohol-dependent subjects. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Basic Medicine2 hsv |
| 650 | 7 | a Neurosciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Medicinska grundvetenskaper2 hsv |
| 650 | 7 | a Neurovetenskaper2 hsv |
| 700 | 1 | a Winham, Stacey J4 aut |
| 700 | 1 | a Preuss, Ulrich W4 aut |
| 700 | 1 | a Zill, Peter4 aut |
| 700 | 1 | a Cunningham, Julie M4 aut |
| 700 | 1 | a Walker, Denise L4 aut |
| 700 | 1 | a Lewis, Kriste A4 aut |
| 700 | 1 | a Geske, Jennifer R4 aut |
| 700 | 1 | a Colby, Colin L4 aut |
| 700 | 1 | a Abulseoud, Osama A4 aut |
| 700 | 1 | a Hall-Flavin, Daniel K4 aut |
| 700 | 1 | a Loukianova, Larissa L4 aut |
| 700 | 1 | a Schneekloth, Terry D4 aut |
| 700 | 1 | a Frye, Mark A4 aut |
| 700 | 1 | a Bazov, Igor4 aut |
| 700 | 1 | a Heit, John A4 aut |
| 700 | 1 | a Bakalkin, Georgy4 aut |
| 700 | 1 | a Mrazek, David A4 aut |
| 700 | 1 | a Biernacka, Joanna M4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 2 | a Molecular neuropsychopharmacology4 oth |
| 710 | 2 | a Molecular Neuropsychopharmacology4 oth |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt International Journal of Neuropsychopharmacologyg 16:5, 975-985x 1461-1457 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189693 |
| 856 | 4 0 | u http://dx.doi.org/10.1017/S1461145712001137 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:582072/FULLTEXT01 |
| 841 | 5 APISa x ab 171207||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-1896932 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189693 |
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