Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma

Sökning: onr:"22097850" > Overexpression of F...

<p>Funding Agencies|Science and Technology Research and Development Program of Hebei Province, China|11276103D-40|</p>
Published
gratis
Objective : To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC. Patients and methods : Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n = 20) and ESCC (n = 64). Results : Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( p = 0.001). The expression of FXYD-3 was correlated with TNM stages and depth of tumour invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( p = 0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (p = 0.063). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis (p = 0.001). However, FXYD-3 expression was not correlated with patient , s gender (p = 0.847), age (p = 0.876), tumour location (p = 0.279), size (p = 0.771) , grade of differentiation (p = 0.279), and survival (p = 0.113). Conclusion : overexpression of FXYD-3 in the cytoplasm may play an important role in the tumourigenesis and development in the human ESCC, particularly in combination with PINCH expression.

Yan, Bao-Yong (författare)
Zhang, Yu (författare)
Yang, Yan-Hong (författare)
Wang, Ming-Wei (författare)
Zentgraf, Hanswalter (författare)
Zhang, Xiang-Hong (författare)
Sun, Xiao-Feng (författare)
Linköpings universitetInstitutionen för klinisk och experimentell medicin347333 (utgivare)
Linköpings universitetHälsouniversitetet (utgivare)
Östergötlands Läns LandstingCentrum för kirurgi, ortopedi och cancervård (utgivare)

Av författaren/redakt...: Zhu, Zhen-Long; Yan, Bao-Yong; Zhang, Yu; Yang, Yan-Hong; Wang, Ming-Wei; Zentgraf, Hanswa ...; visa fler...; Zhang, Xiang-Hon ...; Sun, Xiao-Feng; visa färre...

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