Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

doi:10.1038/sj.bjc.6605416

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Osorio, A. (author)

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

E-article/E-chapterEnglish2009

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2009

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LIBRIS-ID:22116373
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52912uri
urn:nbn:se:liu:diva-52912urn
10.1038/sj.bjc.6605416doi

Supplementary language notes

Language:English

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deldatabas:Eplk_tEPLK

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Published
gratis
BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. METHODS: We have genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach. RESULTS: We found no evidence of association with breast cancer risk for BRCA1 (per-allele HR: 0.98, 95% CI: 0.93-1.04, P = 0.5) or BRCA2 (per-allele HR: 0.97, 95% CI: 0.89-1.06, P = 0.5) mutation carriers. CONCLUSION: This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out.

Subject headings and genre

Medical and Health Sciences hsv
Medicin och hälsovetenskap hsv
MEDICINE svep
MEDICIN svep
BRCA1; BRCA2; ERCC4; breast cancer

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Milne, R L (author)
Pita, G. (author)
Peterlongo, P. (author)
Heikkinen, T. (author)
Simard, J. (author)
Chenevix-Trench, G. (author)
Spurdle, A B (author)
Beesley, J. (author)
Chen, X. (author)
Healey, S. (author)
Neuhausen, S L (author)
Ding, Y C (author)
Couch, F J (author)
Wang, X. (author)
Lindor, N. (author)
Manoukian, S. (author)
Barile, M. (author)
Viel, A. (author)
Tizzoni, L. (author)
Szabo, C I (author)
Foretova, L. (author)
Zikan, M. (author)
Claes, K. (author)
Greene, M H (author)
Mai, P. (author)
Rennert, G. (author)
Lejbkowicz, F. (author)
Barnett-Griness, O. (author)
Andrulis, I L (author)
Ozcelik, H. (author)
Weerasooriya, N. (author)
Gerdes, A-M (author)
Thomassen, M. (author)
Cruger, D G (author)
Caligo, M A (author)
Friedman, E. (author)
Kaufman, B. (author)
Laitman, Y. (author)
Cohen, S.46554 (author)
Kontorovich, T. (author)
Gershoni-Baruch, R. (author)
Dagan, E. (author)
Jernstrom, H. (author)
Stenmark Askmalm, Marie (author)
Arver, B. (author)
Malmer, B. (author)
Domchek, S M (author)
Nathanson, K L (author)
Brunet, J. (author)
Cajal, T. Ramon y (author)
Yannoukakos, D. (author)
Hamann, U. (author)
Hogervorst, F B L (author)
Verhoef, S. (author)
Gomez Garcia, E B (author)
Wijnen, J T (author)
van den Ouweland, A. (author)
Easton, D F (author)
Peock, S. (author)
Cook, M. (author)
Oliver, C T (author)
Frost, D. (author)
Luccarini, C. (author)
Evans, D G (author)
Lalloo, F. (author)
Eeles, R. (author)
Pichert, G. (author)
Cook, J. (author)
Hodgson, S. (author)
Morrison, P J (author)
Douglas, F. (author)
Godwin, A K (author)
Sinilnikova, O M (author)
Barjhoux, L. (author)
Stoppa-Lyonnet, D. (author)
Moncoutier, V. (author)
Giraud, S. (author)
Cassini, C. (author)
Olivier-Faivre, L. (author)
Revillion, F. (author)
Peyrat, J-P (author)
Muller, D. (author)
Fricker, J-P (author)
Lynch, H T (author)
John, E M (author)
Buys, S. (author)
Daly, M. (author)
Hopper, J L (author)
Terry, M B (author)
Miron, A. (author)
Yassin, Y. (author)
Goldgar, D. (author)
Singer, C F (author)
Gschwantler-Kaulich, D. (author)
Pfeiler, G. (author)
Spiess, A-C (author)
v. O. Hansen, Thomas (author)
T. Johannsson, O. (author)
Kirchhoff, T. (author)
Offit, K. (author)
Kosarin, K. (author)
Piedmonte, M. (author)
C. Rodriguez, G. (author)
Wakeley, K. (author)
F. Boggess, J. (author)
Basil, J. (author)
E. Schwartz, P. (author)
V. Blank, S. (author)
E. Toland, A. (author)
Montagna, M. (author)
Casella, C. (author)
N. Imyanitov, E. (author)
Allavena, A. (author)
K. Schmutzler, R. (author)
Versmold, B. (author)
Engel, C. (author)
Meindl, A. (author)
Ditsch, N. (author)
Arnold, N. (author)
Niederacher, D. (author)
Deissler, H. (author)
Fiebig, B. (author)
Varon-Mateeva, R. (author)
Schaefer, D. (author)
G. Froster, U. (author)
Caldes, T. (author)
de la Hoya, M. (author)
McGuffog, L. (author)
C. Antoniou, A. (author)
Nevanlinna, H. (author)
Radice, P. (author)
Benitez, J. (author)
Linköpings universitetInstitutionen för klinisk och experimentell medicin347333 (publisher)
Linköpings universitetHälsouniversitetet (publisher)
Östergötlands Läns LandstingDiagnostikcentrum (publisher)

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In:VärdpublikationBritish Journal of Cancer101:12, 2048-20540007-0920

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By the author/editor: Osorio, A.; Milne, R L; Pita, G.; Peterlongo, P.; Heikkinen, T.; Simard, J.; show more...; Chenevix-Trench, ...; Spurdle, A B; Beesley, J.; Chen, X.; Healey, S.; Neuhausen, S L; Ding, Y C; Couch, F J; Wang, X.; Lindor, N.; Manoukian, S.; Barile, M.; Viel, A.; Tizzoni, L.; Szabo, C I; Foretova, L.; Zikan, M.; Claes, K.; Greene, M H; Mai, P.; Rennert, G.; Lejbkowicz, F.; Barnett-Griness, ...; Andrulis, I L; Ozcelik, H.; Weerasooriya, N.; Gerdes, A-M; Thomassen, M.; Cruger, D G; Caligo, M A; Friedman, E.; Kaufman, B.; Laitman, Y.; Cohen, S.; Kontorovich, T.; Gershoni-Baruch, ...; Dagan, E.; Jernstrom, H.; Stenmark Askmalm ...; Arver, B.; Malmer, B.; Domchek, S M; Nathanson, K L; Brunet, J.; Cajal, T. Ramon ...; Yannoukakos, D.; Hamann, U.; Hogervorst, F B ...; Verhoef, S.; Gomez Garcia, E ...; Wijnen, J T; van den Ouweland ...; Easton, D F; Peock, S.; Cook, M.; Oliver, C T; Frost, D.; Luccarini, C.; Evans, D G; Lalloo, F.; Eeles, R.; Pichert, G.; Cook, J.; Hodgson, S.; Morrison, P J; Douglas, F.; Godwin, A K; Sinilnikova, O M; Barjhoux, L.; Stoppa-Lyonnet, ...; Moncoutier, V.; Giraud, S.; Cassini, C.; Olivier-Faivre, ...; Revillion, F.; Peyrat, J-P; Muller, D.; Fricker, J-P; Lynch, H T; John, E M; Buys, S.; Daly, M.; Hopper, J L; Terry, M B; Miron, A.; Yassin, Y.; Goldgar, D.; Singer, C F; Gschwantler-Kaul ...; Pfeiler, G.; Spiess, A-C; v. O. Hansen, Th ...; T. Johannsson, O ...; Kirchhoff, T.; Offit, K.; Kosarin, K.; Piedmonte, M.; C. Rodriguez, G.; Wakeley, K.; F. Boggess, J.; Basil, J.; E. Schwartz, P.; V. Blank, S.; E. Toland, A.; Montagna, M.; Casella, C.; N. Imyanitov, E.; Allavena, A.; K. Schmutzler, R ...; Versmold, B.; Engel, C.; Meindl, A.; Ditsch, N.; Arnold, N.; Niederacher, D.; Deissler, H.; Fiebig, B.; Varon-Mateeva, R ...; Schaefer, D.; G. Froster, U.; Caldes, T.; de la Hoya, M.; McGuffog, L.; C. Antoniou, A.; Nevanlinna, H.; Radice, P.; Benitez, J.; show less...

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