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  • Stepien, Magdalena (author)

Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans

  • E-article/E-chapterEnglish2017

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  • NATURE PUBLISHING GROUP2017

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  • LIBRIS-ID:22692570
  • http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133525uri
  • urn:nbn:se:umu:diva-133525urn
  • 10.1038/bjc.2017.1doi

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  • Language:English

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  • Background: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n = 106, IHDB n = 34, GBTC n = 96) and their matched controls (1: 1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. Results: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR = 0.36; 95% CI: 0.13-0.98, Ptrend = 0.0123), but no association for copper (OR = 1.06; 95% CI: 0.45-2.46, Ptrend = 0.8878) in multivariable models. The calculated Cu/ Zn ratio showed a positive association for HCC (OR = 4.63; 95% CI: 1.41-15.27, Ptrend = 0.0135). For IHBC and GBTC, no significant associations were observed. Conclusions: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.

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  • Hughes, David J. (author)
  • Hybsier, Sandra (author)
  • Bamia, Christina (author)
  • Tjønneland, Anne (author)
  • Overvad, Kim (author)
  • Affret, Aurélie (author)
  • His, Mathilde (author)
  • Boutron-Ruault, Marie-Christine (author)
  • Katzke, Verena (author)
  • Kuehn, Tilman (author)
  • Aleksandrova, Krasimira (author)
  • Trichopoulou, Antonia (author)
  • Lagiou, Pagona (author)
  • Orfanos, Phlippos (author)
  • Palli, Domenico (author)
  • Sieri, Sabina (author)
  • Tumino, Rosario (author)
  • Ricceri, Fulvio (author)
  • Panico, Salvatore (author)
  • Bueno-de-Mesquita, H. B. (as) (author)
  • Peeters, Petra H. (author)
  • Weiderpass, Elisabete (author)
  • Lasheras, Cristina (author)
  • Bonet Bonet, Catalina (author)
  • Molina-Portillo, Elena (author)
  • Dorronsoro, Miren (author)
  • Maria Huerta, José (author)
  • Barricarte, Aurelio (author)
  • Ohlsson, Bodil (author)
  • Sjöberg, Klas (author)
  • Werner, Mårten (author)
  • Shungin, Dmitry (author)
  • Wareham, Nick (author)
  • Khaw, Kay-Tee (author)
  • Travis, Ruth C. (author)
  • Freisling, Heinz (author)
  • Cross, Amanda J. (author)
  • Schomburg, Lutz (author)
  • Jenab, Mazda (author)
  • Umeå universitetMedicinska fakulteten268483 (publisher)
  • Umeå universitetMedicinska fakulteten268483 (publisher)

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  • In:VärdpublikationBritish Journal of Cancer116:5, 688-6960007-0920

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