Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:du-11504" > Associations of kid...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Fox, Caroline S (author)

Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes : a meta-analysis

Article/chapterEnglish2012

Publisher, publication year, extent ...

2012
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:du-11504
https://urn.kb.se/resolve?urn=urn:nbn:se:du-11504URI
https://doi.org/10.1016/S0140-6736(12)61350-6DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-184992URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Johan Ärnlöv "listed collaborator"
BACKGROUND: Chronic kidney disease is characterised by low estimated glomerular filtration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modified by diabetes is unknown.METHODS: We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes.FINDINGS: We analysed data for 1,024,977 participants (128,505 with diabetes) from 30 general population and high-risk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and high-risk cohorts with data for all-cause mortality, 75,306 deaths occurred during a mean follow-up of 8·5 years (SD 5·0). In the 23 studies with data for cardiovascular mortality, 21,237 deaths occurred from cardiovascular disease during a mean follow-up of 9·2 years (SD 4·9). In the general and high-risk cohorts, mortality risks were 1·2-1·9 times higher for participants with diabetes than for those without diabetes across the ranges of eGFR and albumin-to-creatinine ratio (ACR). With fixed eGFR and ACR reference points in the diabetes and no diabetes groups, HR of mortality outcomes according to lower eGFR and higher ACR were much the same in participants with and without diabetes (eg, for all-cause mortality at eGFR 45 mL/min per 1·73 m(2) [vs 95 mL/min per 1·73 m(2)], HR 1·35; 95% CI 1·18-1·55; vs 1·33; 1·19-1·48 and at ACR 30 mg/g [vs 5 mg/g], 1·50; 1·35-1·65 vs 1·52; 1·38-1·67). The overall interactions were not significant. We identified much the same findings for ESRD in the chronic kidney disease cohorts.INTERPRETATION: Despite higher risks for mortality and ESRD in diabetes, the relative risks of these outcomes by eGFR and ACR are much the same irrespective of the presence or absence of diabetes, emphasising the importance of kidney disease as a predictor of clinical outcomes.FUNDING: US National Kidney Foundation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Matsushita, Kunihiro (author)
Woodward, Mark (author)
Bilo, Henk J G (author)
Chalmers, John (author)
Heerspink, Hiddo J Lambers (author)
Lee, Brian J (author)
Perkins, Robert M (author)
Rossing, Peter (author)
Sairenchi, Toshimi (author)
Tonelli, Marcello (author)
Vassalotti, Joseph A (author)
Yamagishi, Kazumasa (author)
Coresh, Josef (author)
de Jong, Paul E (author)
Wen, Chi-Pang (author)
Nelson, Robert G (author)

Related titles

In:The Lancet380:9854, s. 1662-730140-67361474-547X

Internet link

Find in a library

The Lancet (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Fox, Caroline S; Matsushita, Kuni ...; Woodward, Mark; Bilo, Henk J G; Chalmers, John; Heerspink, Hiddo ...; show more...; Lee, Brian J; Perkins, Robert ...; Rossing, Peter; Sairenchi, Toshi ...; Tonelli, Marcell ...; Vassalotti, Jose ...; Yamagishi, Kazum ...; Coresh, Josef; de Jong, Paul E; Wen, Chi-Pang; Nelson, Robert G; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

Articles in the publication: The Lancet

By the university: Högskolan Dalarna; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se