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Skeletal muscle mor...
Skeletal muscle morphology and risk of cardiovascular disease in elderly men
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- Andersen, Kasper (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Uppsala, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Uppsala, Sweden
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Uppsala, Sweden
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- Ärnlöv, Johan, 1970- (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala University, Uppsala, Sweden,Geriatrik
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- Byberg, Liisa (author)
- Uppsala universitet,Ortopedi,Uppsala University, Uppsala, Sweden
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- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi,Uppsala University, Uppsala, Sweden
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- Sundström, Johan (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2013-10-03
- 2015
- English.
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In: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 22:2, s. 231-239
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: While it is well known that physical inactivity is a major risk factor for cardiovascular disease, there is still a search for the mechanisms by which exercise exerts its positive effect. Skeletal muscle fibre type can be affected to some extent by exercise, and different fibre types possess different anti-inflammatory and glucometabolic properties that may influence cardiovascular disease risk.DESIGN: Population-based cohort study.METHODS: We investigated relations of skeletal muscle morphology to risk of cardiovascular events in a sample of 466 71-year-old men without cardiovascular disease, of which 295 were physically active (strenuous physical activity at least 3 h/week).RESULTS: During a median of 13.1 years of follow up, 173 major cardiovascular events occurred. Among physically active men, 10% higher proportion of type-I (slow-twitch oxidative) fibres was associated with a hazard ratio (HR) of 0.84 (95% confidence interval 0.74-0.95) for cardiovascular events, and 10% higher proportion of type-IIx (fast-twitch glycolytic) fibres was associated with a HR of 1.24 (1.06-1.45), adjusting for age. Similar results were observed in several sets of multivariable-adjusted models. No association of muscle fibre type with risk of cardiovascular events was observed among physically inactive men.CONCLUSIONS: Higher skeletal muscle proportion of type-I fibres was associated with lower risk of cardiovascular events and a higher proportion of type-IIx fibres was associated with higher risk of cardiovascular events. These relations were only observed in physically active men. Skeletal muscle fibre composition may be a mediator of the protective effects of exercise against cardiovascular disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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