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Skeletal muscle mor...
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Andersen, KasperUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Uppsala, Sweden
(author)
Skeletal muscle morphology and risk of cardiovascular disease in elderly men
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2013-10-03
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Oxford University Press (OUP),2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:du-13377
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-13377URI
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https://doi.org/10.1177/2047487313506828DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210441URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: While it is well known that physical inactivity is a major risk factor for cardiovascular disease, there is still a search for the mechanisms by which exercise exerts its positive effect. Skeletal muscle fibre type can be affected to some extent by exercise, and different fibre types possess different anti-inflammatory and glucometabolic properties that may influence cardiovascular disease risk.DESIGN: Population-based cohort study.METHODS: We investigated relations of skeletal muscle morphology to risk of cardiovascular events in a sample of 466 71-year-old men without cardiovascular disease, of which 295 were physically active (strenuous physical activity at least 3 h/week).RESULTS: During a median of 13.1 years of follow up, 173 major cardiovascular events occurred. Among physically active men, 10% higher proportion of type-I (slow-twitch oxidative) fibres was associated with a hazard ratio (HR) of 0.84 (95% confidence interval 0.74-0.95) for cardiovascular events, and 10% higher proportion of type-IIx (fast-twitch glycolytic) fibres was associated with a HR of 1.24 (1.06-1.45), adjusting for age. Similar results were observed in several sets of multivariable-adjusted models. No association of muscle fibre type with risk of cardiovascular events was observed among physically inactive men.CONCLUSIONS: Higher skeletal muscle proportion of type-I fibres was associated with lower risk of cardiovascular events and a higher proportion of type-IIx fibres was associated with higher risk of cardiovascular events. These relations were only observed in physically active men. Skeletal muscle fibre composition may be a mediator of the protective effects of exercise against cardiovascular disease.
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Uppsala, Sweden(Swepub:uu)larslind
(author)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Uppsala University, Uppsala, Sweden(Swepub:uu)ering425
(author)
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Ärnlöv, Johan,1970-Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala University, Uppsala, Sweden,Geriatrik(Swepub:uu)johaarnl
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Byberg, LiisaUppsala universitet,Ortopedi,Uppsala University, Uppsala, Sweden(Swepub:uu)liisbybe
(author)
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Michaëlsson, KarlUppsala universitet,Ortopedi,Uppsala University, Uppsala, Sweden(Swepub:uu)karlmich
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Sundström, JohanUppsala universitet,Kardiovaskulär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Uppsala, Sweden(Swepub:uu)johasund
(author)
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Uppsala universitetKardiovaskulär epidemiologi
(creator_code:org_t)
Related titles
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In:European Journal of Preventive Cardiology: Oxford University Press (OUP)22:2, s. 231-2392047-48732047-4881
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