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Soluble TNF recepto...
Soluble TNF receptors and kidney dysfunction in the elderly
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- Carlsson, Axel C (author)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden ; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Larsson, Tobias E (author)
- Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Helmersson-Karlqvist, Johanna (author)
- Uppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Ärnlöv, Johan, 1970- (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Molekylär epidemiologi
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 25:6, s. 1313-1320
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Abstract
Subject headings
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- The importance of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in the development of kidney disease is being unraveled. Yet, community-based data regarding the role of sTNFRs are lacking. We assessed serum sTNFRs and aspects of kidney damage cross-sectionally in two independent community-based cohorts of elderly participants: Prospective Investigation of the Vasculature in Uppsala Seniors (n=815; mean age, 75 years; 51% women) and Uppsala Longitudinal Study of Adult Men (n=778; mean age, 78 years). Serum sTNFR1 correlated substantially with different aspects of kidney pathology in the Uppsala Longitudinal Study of Adult Men cohort (R=-0.52 for estimated GFR, R=0.22 for urinary albumin-to-creatinine ratio, and R=0.17 for urinary kidney injury molecule-1; P<0.001 for all), with similar correlations in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort. These associations remained significant after adjustment for age, sex, inflammatory markers, and cardiovascular risk factors and were also evident in participants without diabetes. Serum sTNFR2 was associated with all three markers in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort (P<0.001 for all). Our findings from two independent community-based cohorts confirm and extend results of previous studies supporting circulating sTNFRs as relevant biomarkers for kidney damage and dysfunction in elderly individuals, even in the absence of diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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