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Five-year follow-up...
Five-year follow-up of survival and relapse in patients who received cryotherapy during high-dose chemotherapy for stem cell transplantation shows no safety concerns
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- Svanberg, Anncarin (author)
- Uppsala universitet,Hematologi,Prof Gunnar Birgegård,Uppsala Univ, Fac Med, Inst Med Sci, Uppsala, Sweden
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- Öhrn, Kerstin (author)
- Högskolan Dalarna,Vårdvetenskap med inriktning mot munhälsa
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- Birgegård, Gunnar (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Fac Med, Inst Med Sci, Uppsala, Sweden
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(creator_code:org_t)
- 2012-09-11
- 2012
- English.
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In: European Journal of Cancer Care. - : Hindawi Limited. - 0961-5423 .- 1365-2354. ; 21:6, s. 822-828
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Abstract
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- We have previously published a randomised controlled study of the efficacy of cryotherapy in preventing acute oral mucositis after high-dose chemotherapy for stem cell transplantation. The present study is a 5-year follow-up safety study of survival in these patients. In the previously published study oral cryotherapy (cooling of the oral cavity) during high-dose chemotherapy significantly reduced mucositis grade and opiate use in the treated group. All patients were followed up for at least 5 years with regard to relapse and death rates. Baseline data, transplant complications and mucositis data were compared. Significantly more patients (25/39) who received oral cryotherapy were alive after 5 years compared to 15/39 in the control group (P= 0.025). Relapse rates were similar. The only baseline difference was a lower proportion of patients in complete remission at transplantation in the control group (6 vs. 13, P= 0.047). This 5-year follow-up study gave no support for safety concerns with cryotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- prevention; haematopoietic stem cell transplantation; chemotherapy; survival
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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